Yuan Lin

Yuan Lin

Department of Pathology, Sun Yat-sen University

Affiliated withSun Yat-sen UniversityFujian Medical UniversityFujian Maternity and Child Health Hospital

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Research Area

Biography

Yuan-Na Lin is a Research Scholar in the Department of Oncology, Lombardi Cancer Center at Georgetown University School of Medicine, Washington DC. Dr. Lin is a board-certified visceral surgeon at University Hospital Hamburg-Eppendorf, Germany, where she has received her MD and Ph.D.

During her surgical residency, Dr. Lin has been working on the role of actin binding proteins in cancer cell development and metastasis in an interdisciplinary and translational approach. She has been focusing on the formins mDia1 and mDia3 in colon cancer metastasis and chromosomal instability by modulation of the cytoskeleton. She then moved to Georgetown University, Washington DC, USA, as a DFG (German Research Funding Organization) Research Scholar. Here, she set up an innovative 3D tumor spheroid co-culture platform to examine tumor cell – immune cell interactions, in order to reveal new resistance mechanisms towards T-cell mediated tumor cell killing.

As a clinician, Dr. Lin is particularly interested in bridging basic research with clinical application. Her ultimate goal is to improve immunotherapeutic treatment approaches in patients with pancreatic cancer.

JoVE Journal Publications

ArticleTotal : 4
Year
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
Publication title

Cited by 2

2022
2025
2026
2026

Other Publications

Article
Year
Protective effects of non-mitogenic human acidic fibroblast growth factor on hydrogen peroxide-induced damage to cardiomyocytes in vitro.

World journal of gastroenterology : WJG| PubMed ID: 16222742

2005
2011
2011
2012
Overexpression of RPS6KB1 predicts worse prognosis in primary HCC patients.

Medical oncology (Northwood, London, England)| PubMed ID: 22684641

2012
2012
Proteins related to early changes in carcinogenesis of hepatic oval cells after treatment with methylnitronitrosoguanidine.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie| PubMed ID: 24360059

2014
2014
2014
2014
Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 25288727

2014
2014
2015
2015
Activation of Cyclic Adenosine Monophosphate Pathway Increases the Sensitivity of Cancer Cells to the Oncolytic Virus M1.

Molecular therapy : the journal of the American Society of Gene Therapy| PubMed ID: 26373347

2016
2015
2016
2016
2016
2017
2017
2017
2017
2017
Selective replication of oncolytic virus M1 results in a bystander killing effect that is potentiated by Smac mimetics.

Proceedings of the National Academy of Sciences of the United States of America| PubMed ID: 28607091

2017
2017
2018
2017
2018
2018
2018
2018
Association of Low Zinc Finger Antiviral Protein Expression with Progression and Poor Survival of Patients with Hepatocellular Carcinoma.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology| PubMed ID: 30196292

2018
2019
2018
2019
2019
2019
Survey and analysis of the nutritional status in hospitalized patients with malignant gastric tumors and its influence on the quality of life.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer| PubMed ID: 31049672

2020
2019
2019
2020
2019
2019
2020
Sclerosing thymoma with extensive ossification and myasthenia gravis: an extremely rare case in the anterior mediastinum.

International journal of clinical and experimental pathology| PubMed ID: 31966408

2017
Biphenotypic sinonasal sarcoma with diffuse infiltration and intracranial extension: a case report.

International journal of clinical and experimental pathology| PubMed ID: 31966535

2017
The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract| PubMed ID: 32578023

2020
2020
2020
2020
PIWI-interacting RNAs in human cancer.

Seminars in cancer biology| PubMed ID: 32877760

2021
2021
2021
2020
2020
2020
2020
2020
2020
Suppression of CCDC6 sensitizes tumor to oncolytic virus M1.

Neoplasia (New York, N.Y.)| PubMed ID: 33338804

2021
2021
2021
2021
2021
2021
Percutaneous ethanol injection enhanced the efficacy of radiofrequency ablation in the treatment of HCC: an insight into the mechanism of ethanol action.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group| PubMed ID: 34542014

2021
2021
2021
2021
2012
[Polymorphisms of FEM1A gene in patients with polycystic ovary syndrome].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics| PubMed ID: 22678803

2012
[Molecular epidemiological analysis of α- and β-thalassemia in Fujian province].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics| PubMed ID: 23926004

2013
[Protective effect of haliotidis on the oxidative damage in the human lens epithelial cells].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology| PubMed ID: 24330932

2013
2015
Pregnancy after fertility-sparing surgery for borderline ovarian tumors.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics| PubMed ID: 27352738

2016
2016
2017
2017
2018
[Impact of GOLPH3 expression in cumulus granulosa cells on outcomes of intracytoplasmic sperm injection].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University| PubMed ID: 29070465

2017
[Prenatal diagnosis of a fetus with Miller-Dieker syndrome].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics| PubMed ID: 29188621

2017
2017
2018
2018
2018
2018
2019
2018
2018
2018
2019
2019
2019
2019
2019
[Variant analysis for patients from Fujian area with Hong Kong αα type thalassemia].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics| PubMed ID: 30950011

2019
2019
2019
2019
2020
Frequencies and hematological manifestations of the HKαα allele in southern Chinese population.

International journal of clinical and experimental pathology| PubMed ID: 31934145

2019
Identification of a novel pre-terminating mutation in human HBB gene as a cause of β-thalassemia phenotype.

International journal of clinical and experimental pathology| PubMed ID: 31934147

2019
Embryonic protective role of folate in arsenic-induced cardiac malformations in rats.

International journal of clinical and experimental pathology| PubMed ID: 31938300

2018
2020
A rare α-thalassemia deletion, -α, is identified from three Chinese families in Fujian province.

International journal of clinical and experimental pathology| PubMed ID: 31949790

2018
2020
2020
2020
2020
2020
2020
2020
2020
2021
2020
2020
2020
2021
2021
2021
2022
2022
A Novel Necroptosis-Related lncRNA Signature for Osteosarcoma.

Computational and mathematical methods in medicine| PubMed ID: 35844445

2022
2022
2022
2022
2022
Demoralization profiles and their association with depression and quality of life in Chinese patients with cancer: a latent class analysis.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer| PubMed ID: 36308557

2022
2022
Study on diagnosis and management strategies on heterotopic pregnancy: a retrospective study.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology| PubMed ID: 36534044

2023
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.

Journal of orthopaedic surgery and research| PubMed ID: 36717952

2023
2023
2023
2023
2023
2023
2023
2024
2023
2023
2024
Screening behaviors of high-risk individuals for lung cancer: A cross-sectional study.

Asia-Pacific journal of oncology nursing| PubMed ID: 38495639

2024
2024
2024
2024
2024
2025
2025
2025
2024
2024
Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy.

Climacteric : the journal of the International Menopause Society| PubMed ID: 39918216

2025
2025
2025
2025
2025
2025
Helicobacter pylori Infection and Eradication in Relation to Gastroesophageal Reflux Disease.

Journal of gastroenterology and hepatology| PubMed ID: 40662427

2025
2014
2014
2015
2015
2015
2016
Structural and Functional Characterization of the FadR Regulatory Protein from .

Frontiers in cellular and infection microbiology| PubMed ID: 29312893

2017
2018
2019
2019
2019
2019
2020
2020
Gene diagnosis of infantile neurofibromatosis type I: A case report.

World journal of clinical cases| PubMed ID: 33344560

2020
Clinical analysis of adenovirus pneumonia with pulmonary consolidation and atelectasis in children.

The Journal of international medical research| PubMed ID: 33530809

2021
2021
2021
2021
2021
2022
2022
Adverse drug reactions of statin therapy in China from 1989 to 2019: a national database analysis.

European journal of hospital pharmacy : science and practice| PubMed ID: 35728952

2023
2023
2023
2023
Advances in clinical examination of lacrimal gland.

Frontiers in medicine| PubMed ID: 37720501

2023
2024
2024
2024
The maternal drug exposure birth cohort (DEBC) in China.

Nature communications| PubMed ID: 38906856

2024
2024
2024
2024
2024
Case report: Two-step lamellar keratoplasty for alkali burns.

Frontiers in medicine| PubMed ID: 39497839

2024
2024
2024
2025
2025
Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.

Journal of ophthalmic inflammation and infection| PubMed ID: 40591179

2025
A controllable photoresponsive potassium transporter.

Nature communications| PubMed ID: 40721588

2025
2025
2025
2025
2025
2025
2025
2026
2025
2026
2026