Qingjie Li

Qingjie Li

Division of Gastroenterology, University of texas Medical Branch at Galveston

Affiliated withUniversity of texas Medical Branch at GalvestonUniversity of Texas Medical Branch at Galveston

Research Area

Biography

Dr. Li is an Associate Professor in the Division of Gastroenetrology, Department of Internal Medicine, the University of Texas Medical Branch at Galveston. He received

his Master’s Degree in Organic Chemistry from Guangxi Normal University, and a PhD in Biochemistry and Molecular Biology from Central South University, China.

He received his postdoctoral training in Dr. Roderick Dashwood's laboratory at the Linus Pauling Institute, Oregon State University, where he worked on molecular mechanisms and chemoprevention of colorectal cancer. He joined UTMB as a faculty member in 2006.

Dr. Li’s research interests lie in inflammatory bowel disease (IBD), a complex GI disease associated with lifelong medical attention, poor quality of life and huge economic burden, as well as in IBD-associated disorders, including colitis-associated cancer and IBD-induced cardiovascular diseases. Decades of research suggests that the pathogenesis of IBD, including Crohn’s disease and ulcerative colitis, involves abnormal gut microbiota, immune response dysregulation, environmental factors and genetic susceptibility. Specifically, Dr. Li’s research interests include:

• Epigenetic and bacterial contributions to the development of IBD and colitis-associated cancer (CAC);

• Molecular mechanisms underlying IBD-associated cardiovascular disorders;

• Identification of biomarkers and therapeutic targets in IBD and CAC;

• Development of small molecule drugs targeting TRAF6 and MMP7 in inflammatory diseases;

• Phytochemicals as chemopreventive agents against IBD and extraintestinal manifestations of IBD.

JoVE Journal Publications

ArticleTotal : 1
Year
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
Publication title

Cited by 6

2022

Other Publications

Article
Year
Nuclear myosin II regulates the assembly of preinitiation complex for ICAM-1 gene transcription.

Gastroenterology| PubMed ID: 19328794

Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver.

Hepatology research : the official journal of the Japan Society of Hepatology| PubMed ID: 21682828

Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation.

American journal of physiology. Gastrointestinal and liver physiology| PubMed ID: 22517771

Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.

American journal of physiology. Gastrointestinal and liver physiology| PubMed ID: 23681475

Developmental origins of colon smooth muscle dysfunction in IBS-like rats.

American journal of physiology. Gastrointestinal and liver physiology| PubMed ID: 23886858

Chronic prenatal stress epigenetically modifies spinal cord BDNF expression to induce sex-specific visceral hypersensitivity in offspring.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society| PubMed ID: 24588943

2015
Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.

American journal of physiology. Regulatory, integrative and comparative physiology| PubMed ID: 26608656

Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.

Journal of immunology (Baltimore, Md. : 1950)| PubMed ID: 31889022

2021
2022