locomotor-assessment-6-hydroxydopamine-induced-adult-zebrafish-based

Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model

The limitations of current treatments in delaying dopaminergic neuronal loss in Parkinson&#39;s disease (PD) raise the need for alternative therapies that ...

Universiti Teknologi MARA (UiTM), Cawangan Selangor, Kampus Puncak Alam

In order to gauge the impact of proteomics in discovery of Alzheimer's disease (AD) blood-based biomarkers, this study had systematically reviewed articles published between 1984-2019. Articles that fulfilled the inclusion criteria were assessed for risk of bias. A meta-analysis was performed for replicable candidate biomarkers (CB). Of the 1651 articles that were identified, 17 case-control and two cohort studies, as well as three combined case-control and longitudinal designs were shortlisted. A total of 207 AD and mild cognitive impairment (MCI) CB were discovered, with 48 reported in >2 studies. This review highlights six CB, namely alpha-2-macroglobulin (α2M), pancreatic polypeptide (PP), apolipoprotein A-1 (ApoA-1), afamin, insulin growth factor binding protein-2 (IGFBP-2) and fibrinogen-γ-chain, all of which exhibited consistent pattern of regulation in >three independent cohorts. They are involved in AD pathogenesis via amyloid-beta (Aβ), neurofibrillary tangles, diabetes and cardiovascular diseases (CVD). Meta-analysis indicated that ApoA-1 was significantly downregulated in AD (SMD = -1.52, 95% CI: -1.89, -1.16, p < 0.00001), with low inter-study heterogeneity (I = 0%, p = 0.59). α2M was significantly upregulated in AD (SMD = 0.83, 95% CI: 0.05, 1.62, p = 0.04), with moderate inter-study heterogeneity (I = 41%, p = 0.19). Both CB are involved in Aβ formation. These findings provide important insights into blood-based AD biomarkers discovery via proteomics.

Proteomics as a reliable approach for discovery of blood-based Alzheimer's disease biomarkers: A systematic review and meta-analysis.

This systematic review summarised the latest findings on differential composition of gut microbiota in T2DM.

Article	Year
Proteomics as a reliable approach for discovery of blood-based Alzheimer's disease biomarkers: A systematic review and meta-analysis. Ageing research reviews\| PubMed ID: 32294542	2020
Differential gut microbiota composition between type 2 diabetes mellitus patients and healthy controls: A systematic review. Diabetes research and clinical practice\| PubMed ID: 33549678	2021

Kalavathy Ramasamy

Biography

JoVE Journal Publications

Other Publications