Hani A. Awad

Department of Orthopedics, University of Rochester Medical Center

Affiliated withUniversity of Rochester Medical Center University of Rochester

Research Area

Biography

Hani A. Awad has not added Biography.
If you are Hani A. Awad and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2022
Publication title Cited by 1	2025
Publication title	2025

Other Publications

Article	Year
Recent advances in gene delivery for structural bone allografts. Tissue engineering\| PubMed ID: 17518728	2007
Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. Arthritis and rheumatism\| PubMed ID: 18050199	2007
Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18180771	2008
A perspective: engineering periosteum for structural bone graft healing. Clinical orthopaedics and related research\| PubMed ID: 18509709	2008
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins. The Journal of biological chemistry\| PubMed ID: 18567580	2008
Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging. Arthritis and rheumatism\| PubMed ID: 18576355	2008
The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings. Biomaterials\| PubMed ID: 18590929	2008
Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 20187115	2010
Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Annals of the New York Academy of Sciences\| PubMed ID: 20392222	2010
Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. Journal of biomedical materials research. Part A\| PubMed ID: 20725979	2010
Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue engineering. Part A\| PubMed ID: 20807012	2011
A novel animal model for studying silicone gel-related capsular contracture. Plastic and reconstructive surgery\| PubMed ID: 21042104	2010
Self-complementary AAV2.5-BMP2-coated femoral allografts mediated superior bone healing versus live autografts in mice with equivalent biomechanics to unfractured femur. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21206485	2011
TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21445993	2011
The impact of Smad3 loss of function on TGF-β signaling and radiation-induced capsular contracture. Plastic and reconstructive surgery\| PubMed ID: 21617460	2011
Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk. Arthritis and rheumatism\| PubMed ID: 22832945	2012
PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 22991274	2013
Engineering superficial zone features in tissue engineered cartilage. Biotechnology and bioengineering\| PubMed ID: 23239161	2013
Gene expression analysis of the pleiotropic effects of TGF-β1 in an in vitro model of flexor tendon healing. PloS one\| PubMed ID: 23251524	2012
Bone fragility beyond strength and mineral density: Raman spectroscopy predicts femoral fracture toughness in a murine model of rheumatoid arthritis. Journal of biomechanics\| PubMed ID: 23261243	2013
Comparison of an all-inside suture technique with traditional pull-out suture and suture anchor repair techniques for flexor digitorum profundus attachment to bone. The Journal of hand surgery\| PubMed ID: 23578439	2013
Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis. Connective tissue research\| PubMed ID: 23586515	2013
Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur. Bone\| PubMed ID: 23954757	2013
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone\| PubMed ID: 24316420	2014
The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice. Biomaterials\| PubMed ID: 24393269	2014
A mouse model of flexor tendon repair. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 24482166	2014
3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials\| PubMed ID: 24529628	2014
Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone\| PubMed ID: 24530870	2014
Tendon repair is compromised in a high fat diet-induced mouse model of obesity and type 2 diabetes. PloS one\| PubMed ID: 24658034	2014
Freeze-dried allograft-mediated gene or protein delivery of growth and differentiation factor 5 reduces reconstructed murine flexor tendon adhesions. Journal of tissue engineering\| PubMed ID: 24812579	2014
TGF-β1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair. Journal of cellular physiology\| PubMed ID: 24962629	2015
Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 25266795	2015
Loss of the PGE2 receptor EP1 enhances bone acquisition, which protects against age and ovariectomy-induced impairments in bone strength. Bone\| PubMed ID: 25446888	2015
A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone\| PubMed ID: 25459073	2015
Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone\| PubMed ID: 25527421	2015
Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 25761254	2015
3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection. European cells & materials\| PubMed ID: 26535494	2015
Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials\| PubMed ID: 26724454	2016
NOTCH signaling in skeletal progenitors is critical for fracture repair. The Journal of clinical investigation\| PubMed ID: 26950423	2016
3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery. Annals of biomedical engineering\| PubMed ID: 27324800	2017
Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 27933662	2017
Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue. Journal of biophotonics\| PubMed ID: 28464501	2017
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs. Science translational medicine\| PubMed ID: 28515335	2017
Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types. Biomacromolecules\| PubMed ID: 28960967	2017
High dose teriparatide (rPTH1-34) therapy increases callus volume and enhances radiographic healing at 8-weeks in a massive canine femoral allograft model. PloS one\| PubMed ID: 29020057	2017
Teriparatide (human PTH) compensates for impaired fracture healing in COX-2 deficient mice. Bone\| PubMed ID: 29408411	2018
Serpine1 Knockdown Enhances MMP Activity after Flexor Tendon Injury in Mice: Implications for Adhesions Therapy. Scientific reports\| PubMed ID: 29643421	2018
Spatially offset Raman spectroscopy for bone strength prediction. Biomedical optics express\| PubMed ID: 30319902	2018
A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants. mSphere\| PubMed ID: 30381352	2018
Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Devic... Pharmaceutics\| PubMed ID: 30813284	2019
An in vitro platform for elucidating the molecular genetics of S. aureus invasion of the osteocyte lacuno-canalicular network during chronic osteomyelitis. Nanomedicine : nanotechnology, biology, and medicine\| PubMed ID: 31247310	2019
Deletion of NFKB1 enhances canonical NF-κB signaling and increases macrophage and myofibroblast content during tendon healing. Scientific reports\| PubMed ID: 31358843	2019
Transcriptomic Analysis of Cellular Pathways in Healing Flexor Tendons of Plasminogen Activator Inhibitor 1 (PAI-1/Serpine1) Null Mice. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 31424116	2020
Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy". Bone research\| PubMed ID: 31646012	2019
What Regions of the Distal Clavicle Have the Greatest Bone Mineral Density and Cortical Thickness? A Cadaveric Study. Clinical orthopaedics and related research\| PubMed ID: 31764342	2019
Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 32485026	2021
Peritalar Kinematics With Combined Deltoid-Spring Ligament Reconstruction in Simulated Advanced Adult Acquired Flatfoot Deformity. Foot & ankle international\| PubMed ID: 32495639	2020
The Effects of Splitting an Above Elbow Cast: A biomechanical study. Injury\| PubMed ID: 32536528	2020
Identification of Penicillin Binding Protein 4 (PBP4) as a critical factor for Staphylococcus aureus bone invasion during osteomyelitis in mice. PLoS pathogens\| PubMed ID: 33091079	2020
A Mouse Femoral Ostectomy Model to Assess Bone Graft Substitutes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33197009	2021
NF-κB activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival. Science signaling\| PubMed ID: 33203721	2020
Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy. Journal of biomechanics\| PubMed ID: 33485148	2021
A Biomechanical, Cadaveric Evaluation of Single- Versus Double-Row Repair Techniques on Stability of Bony Bankart Lesions. The American journal of sports medicine\| PubMed ID: 33544626	2021
Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis. Frontiers in microbiology\| PubMed ID: 34484165	2021
Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice. Developmental biology\| PubMed ID: 15936013	2005
Biological effects of rAAV-caAlk2 coating on structural allograft healing. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 16043092	2005
Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts. Journal of biomechanics\| PubMed ID: 17524409	2007
Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 18186128	2008
Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 18404739	2008
Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue engineering. Part A\| PubMed ID: 18950290	2009
Remodeling of murine intrasynovial tendon adhesions following injury: MMP and neotendon gene expression. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 19051246	2009
muCT-based measurement of cortical bone graft-to-host union. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 19063685	2009
Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 20842701	2011
EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 20939055	2011
Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model. Bone\| PubMed ID: 20950720	2011
Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice. The American journal of pathology\| PubMed ID: 21550015	2011
Endogenous tissue engineering: PTH therapy for skeletal repair. Cell and tissue research\| PubMed ID: 21626290	2012
Insights into interstitial flow, shear stress, and mass transport effects on ECM heterogeneity in bioreactor-cultivated engineered cartilage hydrogels. Biomechanics and modeling in mechanobiology\| PubMed ID: 21853351	2012
Raman spectroscopy detects deterioration in biomechanical properties of bone in a glucocorticoid-treated mouse model of rheumatoid arthritis. Journal of biomedical optics\| PubMed ID: 21895339	2011
Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 21956542	2012
Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury. PloS one\| PubMed ID: 22792383	2012
Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones. Journal of biomedical optics\| PubMed ID: 23817761	2013
Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair. PloS one\| PubMed ID: 26312751	2015
Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice. Bone research\| PubMed ID: 28529816	2017
Reconstruction of the Superior Glenoid Labrum With Biceps Tendon Autograft: A Cadaveric Biomechanical Study. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association\| PubMed ID: 30591261	2019
Inhibition of the Prostaglandin EP-1 Receptor in Periosteum Progenitor Cells Enhances Osteoblast Differentiation and Fracture Repair. Annals of biomedical engineering\| PubMed ID: 30980293	2020
A murine femoral ostectomy model with hardware exchange to assess antibiotic-impregnated spacers for implant-associated osteomyelitis. European cells & materials\| PubMed ID: 31243755	2019
American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 31545883	2020
American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 31994782	2020
Teriparatide (recombinant parathyroid hormone 1-34) enhances bone allograft integration in a clinically relevant pig model of segmental mandibulectomy. Journal of tissue engineering and regenerative medicine\| PubMed ID: 32483878	2020
A brief history of tendon and ligament bioreactors: Impact and future prospects. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 32579266	2020
Chondral Damage After Arthroscopic Repair Techniques for Acute Bony Bankart Lesions: A Biomechanical Study. The American journal of sports medicine\| PubMed ID: 34236920	2021
Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands. Biomedical optics express\| PubMed ID: 35003849	2021
A high-throughput semi-automated bone segmentation workflow for murine hindpaw micro-CT datasets. Bone reports\| PubMed ID: 35146075	2022
Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse. Scientific reports\| PubMed ID: 35194136	2022
Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery. Frontiers in bioengineering and biotechnology\| PubMed ID: 35360391	2022
Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation. eLife\| PubMed ID: 35635445	2022
Sourcing cells for models of human vascular barriers of inflammation. Frontiers in medical technology\| PubMed ID: 36483299	2022
PAI-1 mediates TGF-β1-induced myofibroblast activation in tenocytes via mTOR signaling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 37143206	2023
Preclinical tendon and ligament models: Beyond the 3Rs (replacement, reduction, and refinement) to 5W1H (why, who, what, where, when, how). Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 37573480	2023
Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones. Journal of biomechanics\| PubMed ID: 37924650	2023
High-throughput micro-CT analysis identifies sex-dependent biomarkers of erosive arthritis in TNF-Tg mice and differential response to anti-TNF therapy. PloS one\| PubMed ID: 38968295	2024
Human Tendon-on-a-Chip for Modeling the Myofibroblast Microenvironment in Peritendinous Fibrosis. Advanced healthcare materials\| PubMed ID: 39544139	2025
Fluid flow impacts endothelial-monocyte interactions in a model of vascular inflammatory fibrosis. Scientific reports\| PubMed ID: 39863621	2025
The Role of Proximal Locking Fixation in Volar Distal Radius Fracture Fixation. Journal of wrist surgery\| PubMed ID: 40151783	2025
Dose-dependent osteoimmunomodulatory effects of amorphous calcium phosphate nanoparticles promote 3D-printed scaffold-mediated bone regeneration. Bioactive materials\| PubMed ID: 40487242	2025