Christoph Handschin

Biozentrum, University of Basel

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2012

Other Publications

Article	Year
A Link between cholesterol levels and phenobarbital induction of cytochromes P450. Biochemical and biophysical research communications\| PubMed ID: 11846416	2002
NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12040014	2002
Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450. The Journal of biological chemistry\| PubMed ID: 12045201	2002
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12764228	2003
Induction of drug metabolism: the role of nuclear receptors. Pharmacological reviews\| PubMed ID: 14657421	2003
In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism. Drug news & perspectives\| PubMed ID: 14668938	2003
Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes & development\| PubMed ID: 14744933	2004
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15100410	2004
Identification of the xenosensors regulating human 5-aminolevulinate synthase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15178759	2004
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals. Nuclear receptor\| PubMed ID: 15479477	2004
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Archives of biochemistry and biophysics\| PubMed ID: 15581595	2005
Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Archives of biochemistry and biophysics\| PubMed ID: 15629111	2005
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell\| PubMed ID: 15680331	2005
LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver. Journal of lipid research\| PubMed ID: 15930522	2005
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell metabolism\| PubMed ID: 16054070	2005
Metabolic control through the PGC-1 family of transcription coactivators. Cell metabolism\| PubMed ID: 16054085	2005
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell\| PubMed ID: 16122419	2005
Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. The Journal of biological chemistry\| PubMed ID: 16574644	2006
Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16980408	2006
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17053067	2006
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell\| PubMed ID: 17055439	2006
RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome. Circulation\| PubMed ID: 17325252	2007
PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & development\| PubMed ID: 17403779	2007
A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17470778	2007
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17609368	2007
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. The Journal of biological chemistry\| PubMed ID: 17702743	2007
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of clinical investigation\| PubMed ID: 17932564	2007
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature\| PubMed ID: 18650917	2008
A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood\| PubMed ID: 18845792	2009
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19066218	2008
The biology of PGC-1Î± and its therapeutic potential. Trends in pharmacological sciences\| PubMed ID: 19446346	2009
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation. Clinical and experimental pharmacology & physiology\| PubMed ID: 19671064	2009
For a pragmatic approach to exercise studies. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 20066760	2010
PGC-1Î± and myokines in the aging muscle - a mini-review. Gerontology\| PubMed ID: 20134150	2011
Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor Î³ coactivator 1Î±. Journal of receptor and signal transduction research\| PubMed ID: 20178454	2010
Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle. PloS one\| PubMed ID: 20532042	2010
SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging\| PubMed ID: 20606253	2010
Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phos... The Journal of biological chemistry\| PubMed ID: 20716531	2010
ApoE-/- PGC-1Î±-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PloS one\| PubMed ID: 21042583	2010
PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell metabolism\| PubMed ID: 21459315	2011
Coordinated balancing of muscle oxidative metabolism through PGC-1Î± increases metabolic flexibility and preserves insulin sensitivity. Biochemical and biophysical research communications\| PubMed ID: 21501593	2011
Remodeling of calcium handling in skeletal muscle through PGC-1Î±: impact on force, fatigability, and fiber type. American journal of physiology. Cell physiology\| PubMed ID: 21918181	2012
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22143799	2011
PGC-1Î± determines light damage susceptibility of the murine retina. PloS one\| PubMed ID: 22348062	2012