Marcus Groettrup

Division of Immunology, University of Konstanz

Research Area

Biography

Marcus Groettrup has not added Biography.
If you are Marcus Groettrup and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10. The Journal of biological chemistry\| PubMed ID: 16707496	2006
Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16887992	2006
Prostaglandin E2 is a key factor for monocyte-derived dendritic cell maturation: enhanced T cell stimulatory capacity despite IDO. Journal of leukocyte biology\| PubMed ID: 17698915	2007
A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins. EMBO reports\| PubMed ID: 17853904	2007
Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis. Journal of cell science\| PubMed ID: 18664492	2008
Identification of homozygous transgenic mice by genomic real-time PCR. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18695958	2008
Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR GreenI-based assay: determining FAT10 mRNA levels in hepatocell... Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 18695959	2008
Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells. Blood\| PubMed ID: 19029446	2009
Identification of the molecular composition of the 20S proteasome of mouse intestine by high-resolution mass spectrometric proteome analysis. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19544023	2009
Substantial reduction of naïve and regulatory T cells following traumatic stress. Brain, behavior, and immunity\| PubMed ID: 19619638	2009
USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis. Nature communications\| PubMed ID: 20975683	2010
Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22043010	2011
Immunoproteasome-specific inhibitors and their application. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22350900	2012
Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 22709589	2012
Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration. Journal of cell science\| PubMed ID: 22797918	2012
Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit. Molecular immunology\| PubMed ID: 22982753	2013
Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 22984077	2012
The immunoproteasome in antigen processing and other immunological functions. Current opinion in immunology\| PubMed ID: 23219269	2013
Using protease inhibitors in antigen presentation assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23329476	2013
FAT10ylation as a signal for proteasomal degradation. Biochimica et biophysica acta\| PubMed ID: 23333871	2014
Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells. BMC psychiatry\| PubMed ID: 23360282	2013
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell\| PubMed ID: 23452861	2013
The unique functions of tissue-specific proteasomes. Trends in biochemical sciences\| PubMed ID: 24286712	2014
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis. EMBO molecular medicine\| PubMed ID: 24399752	2014
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1. The FEBS journal\| PubMed ID: 24528925	2014
The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial. Journal of psychiatric research\| PubMed ID: 24726027	2014
Subunit specific inhibitors of proteasomes and their potential for immunomodulation. Current opinion in chemical biology\| PubMed ID: 25217863	2014
The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice. Journal of cell science\| PubMed ID: 25271057	2014
No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes. Immunogenetics\| PubMed ID: 25403261	2015
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation. PloS one\| PubMed ID: 25768649	2015
Analgesia in mice with experimental meningitis reduces pain without altering immune parameters. ALTEX\| PubMed ID: 25800953	2015
The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. Molecular immunology\| PubMed ID: 25983082	2015
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nature immunology\| PubMed ID: 26214742	2015
Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26276509	2015
The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26401002	2015
The immunoproteasome: a novel drug target for autoimmune diseases. Clinical and experimental rheumatology\| PubMed ID: 26458097	2015
Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis. European journal of immunology\| PubMed ID: 26464284	2016
Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation. Molecular immunology\| PubMed ID: 26598275	2016
The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carci... The Prostate\| PubMed ID: 26715028	2016
Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice. Scientific reports\| PubMed ID: 26776888	2016
A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nature chemical biology\| PubMed ID: 27182664	2016
The ubiquitin-like modifier FAT10 in cancer development. The international journal of biochemistry & cell biology\| PubMed ID: 27393295	2016
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. Nucleic acids research\| PubMed ID: 27694308	2016
Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10. FEBS letters\| PubMed ID: 27926780	2017
Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation. Molecular immunology\| PubMed ID: 28157553	2017
Chronic stress suppresses anti-tumor T responses and tumor regression following cancer immunotherapy in a mouse model of melanoma. Brain, behavior, and immunity\| PubMed ID: 28457810	2017
No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Molecular immunology\| PubMed ID: 28582644	2017
Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice. Oncotarget\| PubMed ID: 28881611	2017
Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome. British journal of pharmacology\| PubMed ID: 29034459	2018
The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire. European journal of immunology\| PubMed ID: 29067678	2018
The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10. Molecular immunology\| PubMed ID: 29208314	2019
Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation. Kidney international\| PubMed ID: 29229189	2018
The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics\| PubMed ID: 29508036	2018
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency. Scientific reports\| PubMed ID: 29654304	2018
The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nature communications\| PubMed ID: 30127417	2018
On the role of the immunoproteasome in transplant rejection. Immunogenetics\| PubMed ID: 30220008	2019
Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO reports\| PubMed ID: 30279279	2018
Author Correction: The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nature communications\| PubMed ID: 30389928	2018
Prevention of neuronal apoptosis by astrocytes through thiol-mediated stress response modulation and accelerated recovery from proteotoxic stress. Cell death and differentiation\| PubMed ID: 30390092	2018
Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis. Frontiers in immunology\| PubMed ID: 30416500	2018
Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors. Kidney international\| PubMed ID: 30685098	2019
The ubiquitin-like modifier FAT10 stimulates the activity of deubiquitylating enzyme OTUB1. The Journal of biological chemistry\| PubMed ID: 30718280	2019
The ubiquitin-like modifier FAT10 is required for normal IFN-γ production by activated CD8 T cells. Molecular immunology\| PubMed ID: 30818228	2019
Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10. Methods in enzymology\| PubMed ID: 30850054	2019
Harnessing Dendritic Cells for Poly (D,L-lactide--glycolide) Microspheres (PLGA MS)-Mediated Anti-tumor Therapy. Frontiers in immunology\| PubMed ID: 31024545	2019
Testing the Impact of Protease Inhibitors in Antigen Presentation Assays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 31147932	2019
Immunoproteasome Inhibition Selectively Kills Human CD14 Monocytes and as a Result Dampens IL-23 Secretion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 31484727	2019
The ubiquitin-like modifier FAT10 interferes with SUMO activation. Nature communications\| PubMed ID: 31575873	2019
Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome. ACS central science\| PubMed ID: 32123742	2020
FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly. Journal of cell science\| PubMed ID: 32546531	2020
Regulation of Interferon Induction by the Ubiquitin-Like Modifier FAT10. Biomolecules\| PubMed ID: 32586037	2020
Evidence for an involvement of the ubiquitin-like modifier ISG15 in MHC class I antigen presentation. European journal of immunology\| PubMed ID: 32686110	2021
The ubiquitin-like modifier FAT10 - much more than a proteasome-targeting signal. Journal of cell science\| PubMed ID: 32719056	2020
The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation. The Journal of biological chemistry\| PubMed ID: 32817338	2020
Recent insights how combined inhibition of immuno/proteasome subunits enables therapeutic efficacy. Genes and immunity\| PubMed ID: 32839530	2020
Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy. Cell reports\| PubMed ID: 33730565	2021
Immunoproteasome Upregulation Is Not Required to Control Protein Homeostasis during Viral Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 33731337	2021
Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen. Biochemical and biophysical research communications\| PubMed ID: 33774280	2021
PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy. Nature communications\| PubMed ID: 34006895	2021
On the Role of the Immunoproteasome in Protein Homeostasis. Cells\| PubMed ID: 34831438	2021