Urs Christen

Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

Affiliated withGoethe University Hospital Frankfurt

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 31	2012

Other Publications

Article	Year
Apoptosis of autoreactive CD8 lymphocytes as a potential mechanism for the abrogation of type 1 diabetes by islet-specific TNF-alpha expression at a time when the autoimmune process is alrea... Annals of the New York Academy of Sciences\| PubMed ID: 12021099	2002
Discrete proteolysis of focal contact and adherens junction components in Porphyromonas gingivalis-infected oral keratinocytes: a strategy for cell adhesion and migration disabling. Infection and immunity\| PubMed ID: 12228316	2002
Molecular anatomy of antigen-specific CD8(+) T cell engagement and synapse formation in vivo. Nature immunology\| PubMed ID: 12352968	2002
Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model. Transgenic research\| PubMed ID: 12509133	2002
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature\| PubMed ID: 12594515	2003
Cytokines and chemokines in virus-induced autoimmunity. Advances in experimental medicine and biology\| PubMed ID: 12613580	2003
Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14662890	2003
Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient. The Journal of clinical investigation\| PubMed ID: 14702111	2004
Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells. Diabetes\| PubMed ID: 14988242	2004
Induction, acceleration or prevention of autoimmunity by molecular mimicry. Molecular immunology\| PubMed ID: 15036917	2004
Virally induced inflammation and therapeutic avenues in type 1 diabetes. Endocrinology and metabolism clinics of North America\| PubMed ID: 15053894	2004
CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science (New York, N.Y.)\| PubMed ID: 15105501	2004
Initiation of autoimmunity. Current opinion in immunology\| PubMed ID: 15511670	2004
IP-10 and type 1 diabetes: a question of time and location. Autoimmunity\| PubMed ID: 15518041	2004
A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. The Journal of clinical investigation\| PubMed ID: 15520861	2004
Manipulating the type 1 vs type 2 balance in type 1 diabetes. Immunologic research\| PubMed ID: 15531772	2004
IP-10 and type 1 diabetes: a question of time and location. Autoimmunity\| PubMed ID: 15672495	2004
Different diabetogenic potential of autoaggressive CD8+ clones associated with IFN-gamma-inducible protein 10 (CXC chemokine ligand 10) production but not cytokine expression, cytolytic acti... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15728483	2005
Infections and autoimmunity--good or bad? Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15944245	2005
Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16148094	2005
Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clinical microbiology reviews\| PubMed ID: 16418524	2006
Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies. Clinical & developmental immunology\| PubMed ID: 16603445	2006
SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes. Journal of autoimmunity\| PubMed ID: 17045460	2006
Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies. Clinical & developmental immunology\| PubMed ID: 17162375	2006
Chemokines as drug targets in type 1 diabetes. Endocrine, metabolic & immune disorders drug targets\| PubMed ID: 17346199	2007
Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice. Diabetes\| PubMed ID: 17395746	2007
Animal models for autoimmune hepatitis. Autoimmunity reviews\| PubMed ID: 17412303	2007
Systemic anti-TNFalpha treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. The Journal of investigative dermatology\| PubMed ID: 17460730	2007
Viral infection--a cure for type 1 diabetes? Current medicinal chemistry\| PubMed ID: 17691946	2007
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection. The Journal of experimental medicine\| PubMed ID: 18474629	2008
New animal models for autoimmune hepatitis. Seminars in liver disease\| PubMed ID: 19675999	2009
Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty? Journal of autoimmunity\| PubMed ID: 19716269	2010
Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19887639	2009
Enterovirus infection of human beta-cells activates dendritic cells and triggers innate antiviral responses: are enteroviruses convicted now? Diabetes\| PubMed ID: 20427698	2010
Cytochrome P450 2D6 as a model antigen. Digestive diseases (Basel, Switzerland)\| PubMed ID: 20460894	2010
CXCL10 promotes liver fibrosis by prevention of NK cell mediated hepatic stellate cell inactivation. Journal of autoimmunity\| PubMed ID: 20932719	2010
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1. PLoS pathogens\| PubMed ID: 20976193	2010
Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference? Cellular & molecular immunology\| PubMed ID: 21258361	2011
Epitope spreading of the anti-CYP2D6 antibody response in patients with autoimmune hepatitis and in the CYP2D6 mouse model. Journal of autoimmunity\| PubMed ID: 21795021	2011