Karen S. Wilcox

Department of Pharmacology and Toxicology, University of Utah

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 7	2022

Other Publications

Article	Year
Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Molecular pharmacology\| PubMed ID: 11901232	2002
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Journal of neurophysiology\| PubMed ID: 12522160	2003
Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents. British journal of pharmacology\| PubMed ID: 12598414	2003
The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs. Epilepsy research\| PubMed ID: 15135163	2004
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia\| PubMed ID: 15329063	2004
A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16481438	2006
Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors. Neuropharmacology\| PubMed ID: 16490221	2006
Effect of Conantokin G on NMDA receptor-mediated spontaneous EPSCs in cultured cortical neurons. Journal of neurophysiology\| PubMed ID: 16760339	2006
A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents. Journal of neuroscience methods\| PubMed ID: 16899300	2007
Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. European journal of pharmacology\| PubMed ID: 17056029	2006
Discovery of antiepileptic drugs. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics\| PubMed ID: 17199014	2007
Differential contribution of kainate receptors to excitatory postsynaptic currents in superficial layer neurons of the rat medial entorhinal cortex. Neuroscience\| PubMed ID: 17395391	2007
Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro. Epilepsy research\| PubMed ID: 17395429	2007
Mechanisms of action of antiepileptic drugs. International review of neurobiology\| PubMed ID: 17433919	2007
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC). Epilepsy research\| PubMed ID: 18262393	2008
Seizures following picornavirus infection. Epilepsia\| PubMed ID: 18325012	2008
Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. The Journal of physiology\| PubMed ID: 18483067	2008
Differences in excitatory transmission between thalamic and cortical afferents to single spiny efferent neurons of rat dorsal striatum. The European journal of neuroscience\| PubMed ID: 19046385	2008
Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions. Epilepsia\| PubMed ID: 19453707	2009
Innate but not adaptive immune responses contribute to behavioral seizures following viral infection. Epilepsia\| PubMed ID: 19845729	2010
Theiler's virus infection chronically alters seizure susceptibility. Epilepsia\| PubMed ID: 20002148	2010
Role for complement in the development of seizures following acute viral infection. Journal of virology\| PubMed ID: 20427530	2010
Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice. Journal of neuropathology and experimental neurology\| PubMed ID: 21107134	2010
CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors. Neurotoxicology\| PubMed ID: 21396956	2011
Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors. Pharmacological research\| PubMed ID: 21421049	2011
Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection. Journal of virology\| PubMed ID: 21543484	2011
cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors. Epilepsy research\| PubMed ID: 21665439	2011
Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection. Journal of virology\| PubMed ID: 21680509	2011
Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6. Journal of neurovirology\| PubMed ID: 21833798	2011
Altered learning and Arc-regulated consolidation of learning in striatum by methamphetamine-induced neurotoxicity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 22071872	2012
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia\| PubMed ID: 22150444	2012
The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy. Journal of neurovirology\| PubMed ID: 22328242	2012
Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy. Epilepsia\| PubMed ID: 23750799	2013
Issues related to development of new antiseizure treatments. Epilepsia\| PubMed ID: 23909851	2013
The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus. Journal of neuropathology and experimental neurology\| PubMed ID: 24042195	2013
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of medicinal chemistry\| PubMed ID: 24205976	2013
Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy. Neurobiology of disease\| PubMed ID: 24412221	2014
Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice. Epilepsia\| PubMed ID: 24447124	2014
Does brain inflammation mediate pathological outcomes in epilepsy? Advances in experimental medicine and biology\| PubMed ID: 25012376	2014
The challenge and promise of anti-epileptic therapy development in animal models. The Lancet. Neurology\| PubMed ID: 25127174	2014
Imaging activity in neurons and glia with a Polr2a-based and cre-dependent GCaMP5G-IRES-tdTomato reporter mouse. Neuron\| PubMed ID: 25155958	2014
Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbid... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25755209	2015
Imaging activity in astrocytes and neurons with genetically encoded calcium indicators following in utero electroporation. Frontiers in molecular neuroscience\| PubMed ID: 25926768	2015
Oxidative stress in murine Theiler's virus-induced temporal lobe epilepsy. Experimental neurology\| PubMed ID: 26079647	2015
Altered structure and function of astrocytes following status epilepticus. Epilepsy & behavior : E&B\| PubMed ID: 26219575	2015
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures. Experimental neurology\| PubMed ID: 26896834	2016
Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy. Journal of neuropathology and experimental neurology\| PubMed ID: 26945036	2016
NBQX, a highly selective competitive antagonist of AMPA and KA ionotropic glutamate receptors, increases seizures and mortality following picornavirus infection. Experimental neurology\| PubMed ID: 27072529	2016
Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy. Epilepsia\| PubMed ID: 27739576	2016
Validation of a Preclinical Drug Screening Platform for Pharmacoresistant Epilepsy. Neurochemical research\| PubMed ID: 28303498	2017
Development and pharmacologic characterization of the rat 6 Hz model of partial seizures. Epilepsia\| PubMed ID: 28449218	2017
Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochemical research\| PubMed ID: 28478594	2017
Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy. eNeuro\| PubMed ID: 28497109	2017
Preclinical Comparison of Mechanistically Different Antiseizure, Antinociceptive, and/or Antidepressant Drugs in a Battery of Rodent Models of Nociceptive and Neuropathic Pain. Neurochemical research\| PubMed ID: 28508174	2017
Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss. Neurobiology of disease\| PubMed ID: 28624414	2017
Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research? Epilepsy & behavior : E&B\| PubMed ID: 29097123	2018
Novel Targets for Developing Antiseizure and, Potentially, Antiepileptogenic Drugs. Epilepsy currents\| PubMed ID: 29225544	2017
Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs. Epilepsia\| PubMed ID: 30328622	2018
Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 30504280	2019
Genetic and pharmacological manipulation of glial glutamate transporters does not alter infection-induced seizure activity. Experimental neurology\| PubMed ID: 31022385	2019
Cannabidiol reduces seizures following CNS infection with Theiler's murine encephalomyelitis virus. Epilepsia open\| PubMed ID: 31440724	2019
Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model. Epilepsia open\| PubMed ID: 31440726	2019
The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy. Neuropharmacology\| PubMed ID: 31790717	2020
Ultrastructural and functional changes at the tripartite synapse during epileptogenesis in a model of temporal lobe epilepsy. Experimental neurology\| PubMed ID: 31935368	2020
Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures. Journal of medicinal chemistry\| PubMed ID: 32390424	2020
Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats. Epilepsia\| PubMed ID: 32420627	2020
Accurate detection of spontaneous seizures using a generalized linear model with external validation. Epilepsia\| PubMed ID: 32761902	2020
Reactivity and increased proliferation of NG2 cells following central nervous system infection with Theiler's murine encephalomyelitis virus. Journal of neuroinflammation\| PubMed ID: 33272299	2020
Identification of clinically relevant biomarkers of epileptogenesis - a strategic roadmap. Nature reviews. Neurology\| PubMed ID: 33594276	2021
Response: Usefulness of the post-kainate spontaneous recurrent seizure model for screening for antiseizure and for neuroprotective effects. Epilepsia\| PubMed ID: 33778946	2021
Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program. Epilepsia\| PubMed ID: 34002394	2021
Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease m... Epilepsia open\| PubMed ID: 34033232	2021
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital. Epilepsia\| PubMed ID: 34080183	2021
Screening of prototype antiseizure and anti-inflammatory compounds in the Theiler's murine encephalomyelitis virus model of epilepsy. Epilepsia open\| PubMed ID: 34668659	2022
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs. Experimental neurology\| PubMed ID: 34922908	2022
Inflammation Unleashed in Viral-Induced Epileptogenesis. Epilepsy currents\| PubMed ID: 34924851	2021