Eleonora Mezzaroma

Department of Pharmacotherapy and Outcome Science, Virginia Commonwealth University

Affiliated withVirginia Commonwealth University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2022

Other Publications

Article	Year
Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice. Journal of cardiovascular pharmacology\| PubMed ID: 20881611	2010
Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse. PloS one\| PubMed ID: 21455304	2011
Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy. Circulation. Arrhythmia and electrophysiology\| PubMed ID: 21576277	2011
Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury. Journal of molecular and cellular cardiology\| PubMed ID: 21600901	2011
Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 21637911	2011
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22106299	2011
Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse. PloS one\| PubMed ID: 22140485	2011
A mouse model of radiation-induced cardiomyopathy. International journal of cardiology\| PubMed ID: 22340985	2012
Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure. PloS one\| PubMed ID: 22438931	2012
Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse. Cardiovascular drugs and therapy\| PubMed ID: 22527620	2012
GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 22923737	2012
Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse. Experimental physiology\| PubMed ID: 23180808	2013
Inhibition of apoptosis signal-regulating kinase 1 reduces myocardial ischemia-reperfusion injury in the mouse. Journal of the American Heart Association\| PubMed ID: 23316291	2012
Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse. PloS one\| PubMed ID: 23516478	2013
Targeting interleukin-1 in heart disease. Circulation\| PubMed ID: 24146121	2013
A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. Journal of cardiovascular pharmacology\| PubMed ID: 24336017	2014
Formation of the inflammasome in acute myocarditis. International journal of cardiology\| PubMed ID: 24439778	2014
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 24531812	2014
Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 24804827	2014
Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice. Circulation. Cardiovascular genetics\| PubMed ID: 24825878	2014
Letter by Mezzaroma, et al regarding article, "NLRP3 inflammasome as a therapeutic target in myocardial infarction". International heart journal\| PubMed ID: 24942779	2014
Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse. Journal of cardiovascular pharmacology\| PubMed ID: 25006675	2014
Response to letter regarding article, "targeting interleukin-1 in heart disease". Circulation\| PubMed ID: 25114193	2014
The inflammasome in myocardial injury and cardiac remodeling. Antioxidants & redox signaling\| PubMed ID: 25330141	2015
Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart. Cardiovascular research\| PubMed ID: 25524927	2015
Effects of dimethyl sulfoxide on the NLRP3 inflammasome. Immunobiology\| PubMed ID: 25743943	2015
Role of Interleukin-1 in Radiation-Induced Cardiomyopathy. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 25822795	2015
Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse. Journal of cardiovascular pharmacology\| PubMed ID: 25915511	2015
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice. International journal of cardiology\| PubMed ID: 26151718	2015
A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 26188021	2015
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse. International journal of cardiology\| PubMed ID: 26896627	2016
Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition. Journal of cardiovascular pharmacology\| PubMed ID: 26945157	2016
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death. International journal of molecular sciences\| PubMed ID: 27322252	2016
Biomarkers of cardiac injury in patients undergoing thoracic radiation therapy. International journal of cardiology\| PubMed ID: 27552565	2016
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects. Radiation research\| PubMed ID: 27841740	2016
A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction. Journal of cardiovascular pharmacology\| PubMed ID: 28195949	2017
Reduction of Myocardial Ischemia-Reperfusion Injury by Inhibiting Interleukin-1 Alpha. Journal of cardiovascular pharmacology\| PubMed ID: 28267688	2017
Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction. JACC. Basic to translational science\| PubMed ID: 30062167	2017
Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction. JACC. Basic to translational science\| PubMed ID: 30062170	2017
An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice. Journal of cardiovascular pharmacology\| PubMed ID: 30422890	2018
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. Journal of cardiovascular pharmacology\| PubMed ID: 30747785	2019
NLRP3 Inflammasome in Acute Myocardial Infarction. Journal of cardiovascular pharmacology\| PubMed ID: 31356555	2019
Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors. The American journal of cardiology\| PubMed ID: 31928717	2020
Targeting the NLRP3 inflammasome to reduce warm ischemic injury in donation after circulatory death heart. Clinical transplantation\| PubMed ID: 32654189	2020
Modulation of Interleukin-1 and -18 Mediated Injury in Donation after Circulatory Death Mouse Hearts. The Journal of surgical research\| PubMed ID: 32896815	2021
The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches. JACC. Basic to translational science\| PubMed ID: 33665514	2021
NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases. Molecules (Basel, Switzerland)\| PubMed ID: 33673188	2021
Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation. Radiation research\| PubMed ID: 33822229	2021
Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Repe... Molecules (Basel, Switzerland)\| PubMed ID: 34207886	2021
Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts. Animal models and experimental medicine\| PubMed ID: 34557655	2021
Improving circulatory death donor heart function: A novel approach. JTCVS techniques\| PubMed ID: 34647070	2021
Targeting the NLRP3 inflammasome in cardiovascular diseases. Pharmacology & therapeutics\| PubMed ID: 34906598	2021
The inflammasome in heart failure. Current opinion in physiology\| PubMed ID: 34917871	2021
The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice. Cytokine\| PubMed ID: 35091314	2022
Assessment of machine perfusion conditions for the donation after circulatory death heart preservation. Artificial organs\| PubMed ID: 35167122	2022