Rick L. Tarleton

Center for Tropical and Emerging Global Diseases, University of Georgia

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2022

Other Publications

Article	Year
Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Infection and immunity\| PubMed ID: 9784506	1998
Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection. Infection and immunity\| PubMed ID: 12228281	2002
Cutting edge: dysfunctional CD8+ T cells reside in nonlymphoid tissues during chronic Trypanosoma cruzi infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12594245	2003
Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR. Molecular and biochemical parasitology\| PubMed ID: 12798506	2003
Genetic immunization with LYT1 or a pool of trans-sialidase genes protects mice from lethal Trypanosoma cruzi infection. Vaccine\| PubMed ID: 12798651	2003
Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi. Molecular and biochemical parasitology\| PubMed ID: 12967712	2003
Chagas disease: a role for autoimmunity? Trends in parasitology\| PubMed ID: 14519582	2003
TcruziDB: an integrated Trypanosoma cruzi genome resource. Nucleic acids research\| PubMed ID: 14681430	2004
Inducible nitric oxide synthase is not essential for control of Trypanosoma cruzi infection in mice. Infection and immunity\| PubMed ID: 15213153	2004
Antigen-specific T cells maintain an effector memory phenotype during persistent Trypanosoma cruzi infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15661921	2005
A Heuristic method for assigning a false-discovery rate for protein identifications from Mascot database search results. Molecular & cellular proteomics : MCP\| PubMed ID: 15703444	2005
New approaches in vaccine development for parasitic infections. Cellular microbiology\| PubMed ID: 16153238	2005
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS pathogens\| PubMed ID: 16879036	2006
A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi. Genome biology\| PubMed ID: 17567905	2007
Immune system recognition of Trypanosoma cruzi. Current opinion in immunology\| PubMed ID: 17651955	2007
TGF-beta regulates pathology but not tissue CD8+ T cell dysfunction during experimental Trypanosoma cruzi infection. European journal of immunology\| PubMed ID: 17823982	2007
The challenges of Chagas Disease-- grim outlook or glimmer of hope. PLoS medicine\| PubMed ID: 18162039	2007
Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nature medicine\| PubMed ID: 18425131	2008
Stable CD8+ T cell memory during persistent Trypanosoma cruzi infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 18684955	2008
High throughput selection of effective serodiagnostics for Trypanosoma cruzi infection. PLoS neglected tropical diseases\| PubMed ID: 18841200	2008
HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS neglected tropical diseases\| PubMed ID: 18846233	2008
Eliminating Chagas disease: challenges and a roadmap. BMJ (Clinical research ed.)\| PubMed ID: 19366739	2009
Evaluation of high efficiency gene knockout strategies for Trypanosoma cruzi. BMC microbiology\| PubMed ID: 19432966	2009
Chromosome level assembly of the hybrid Trypanosoma cruzi genome. BMC genomics\| PubMed ID: 19486522	2009
Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19553540	2009
CD8+ T cells in Trypanosoma cruzi infection. Current opinion in immunology\| PubMed ID: 19646853	2009
The steady-state transcriptome of the four major life-cycle stages of Trypanosoma cruzi. BMC genomics\| PubMed ID: 19664227	2009
Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 19692645	2009
Changes in Trypanosoma cruzi-specific immune responses after treatment: surrogate markers of treatment efficacy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 19877967	2009
Trypanosoma cruzi-specific immune responses in subjects from endemic areas of Chagas disease of Argentina. Microbes and infection\| PubMed ID: 20123034	2010
Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling. Infection and immunity\| PubMed ID: 20457790	2010
CD8+ T cells specific for immunodominant trans-sialidase epitopes contribute to control of Trypanosoma cruzi infection but are not required for resistance. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 20530265	2010
In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds. PLoS neglected tropical diseases\| PubMed ID: 20644616	2010
Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization. BMC genomics\| PubMed ID: 21385342	2011
Oral exposure to Trypanosoma cruzi elicits a systemic CD8⁺ T cell response and protection against heterotopic challenge. Infection and immunity\| PubMed ID: 21628516	2011
Methodological advances in drug discovery for Chagas disease. Expert opinion on drug discovery\| PubMed ID: 21712965	2011
Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge. PLoS neglected tropical diseases\| PubMed ID: 22180798	2011
Transgenic parasites accelerate drug discovery. Trends in parasitology\| PubMed ID: 22277131	2012
Inhibitory receptors are expressed by Trypanosoma cruzi-specific effector T cells and in hearts of subjects with chronic Chagas disease. PloS one\| PubMed ID: 22574131	2012
Report of the 2nd Chagas Drug Discovery Consortium meeting, held on 3 November 2010; Atlanta GA, USA. Expert opinion on drug discovery\| PubMed ID: 22646217	2011
Is Chagas disease really the "new HIV/AIDS of the Americas"? PLoS neglected tropical diseases\| PubMed ID: 23145193	2012
A systematic review of high quality diagnostic tests for Chagas disease. PLoS neglected tropical diseases\| PubMed ID: 23145201	2012
New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection in mice. The Journal of infectious diseases\| PubMed ID: 23945371	2014
Evidence for the role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Molecular microbiology\| PubMed ID: 24033456	2013
Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen. Nature communications\| PubMed ID: 24149620	2013
Frequency of IFNγ-producing T cells correlates with seroreactivity and activated T cells during canine Trypanosoma cruzi infection. Veterinary research\| PubMed ID: 24456537	2014
The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells. Cell host & microbe\| PubMed ID: 25299330	2014
Chagas disease and the london declaration on neglected tropical diseases. PLoS neglected tropical diseases\| PubMed ID: 25299701	2014
CRISPR-Cas9-mediated single-gene and gene family disruption in Trypanosoma cruzi. mBio\| PubMed ID: 25550322	2014
Chemokine receptor 7 (CCR7)-expression and IFNγ production define vaccine-specific canine T-cell subsets. Veterinary immunology and immunopathology\| PubMed ID: 25758065	2015
CD8+ T cells in Trypanosoma cruzi infection. Seminars in immunopathology\| PubMed ID: 25921214	2015
A framework for ontology-based question answering with application to parasite immunology. Journal of biomedical semantics\| PubMed ID: 26185615	2015
Long-Term Immunity to Trypanosoma cruzi in the Absence of Immunodominant trans-Sialidase-Specific CD8+ T Cells. Infection and immunity\| PubMed ID: 27354447	2016
Chagas Disease: A Solvable Problem, Ignored. Trends in molecular medicine\| PubMed ID: 27523778	2016
Recombination-driven generation of the largest pathogen repository of antigen variants in the protozoan Trypanosoma cruzi. BMC genomics\| PubMed ID: 27619017	2016
The Significance of Discordant Serology in Chagas Disease: Enhanced T-Cell Immunity to in Serodiscordant Subjects. Frontiers in immunology\| PubMed ID: 28966620	2017
Rapid, Selection-Free, High-Efficiency Genome Editing in Protozoan Parasites Using CRISPR-Cas9 Ribonucleoproteins. mBio\| PubMed ID: 29114029	2017
Spontaneous dormancy protects during extended drug exposure. eLife\| PubMed ID: 29578409	2018
Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection. PLoS pathogens\| PubMed ID: 30419010	2018
Drug Discovery for Kinetoplastid Diseases: Future Directions. ACS infectious diseases\| PubMed ID: 30543391	2019
Protozoan persister-like cells and drug treatment failure. Nature reviews. Microbiology\| PubMed ID: 31444481	2019
Chagas Disease Drug Discovery: Multiparametric Lead Optimization against in Acylaminobenzothiazole Series. Journal of medicinal chemistry\| PubMed ID: 31657555	2019
New Scheme of Intermittent Benznidazole Administration in Patients Chronically Infected with Trypanosoma cruzi: Clinical, Parasitological, and Serological Assessment after Three Years of Fol... Antimicrobial agents and chemotherapy\| PubMed ID: 32571827	2020
Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32591392	2020
A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease. Science translational medicine\| PubMed ID: 33115952	2020
Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease. PLoS pathogens\| PubMed ID: 33508020	2021
A flexible, pan-species, multi-antigen platform for the detection and monitoring of SARS-CoV-2-specific antibody responses. medRxiv : the preprint server for health sciences\| PubMed ID: 33532799	2021
Reduced Trypanosoma cruzi-specific humoral response and enhanced T cell immunity after treatment interruption with benznidazole in chronic Chagas disease. The Journal of antimicrobial chemotherapy\| PubMed ID: 33693664	2021
High variation in immune responses and parasite phenotypes in naturally acquired Trypanosoma cruzi infection in a captive non-human primate breeding colony in Texas, USA. PLoS neglected tropical diseases\| PubMed ID: 33788859	2021