left-anterior-descending-coronary-artery-ligation-for-ischemia

Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control

Coronary heart disease is the leading cause of death globally. Complete cessation of blood flow in coronary arteries causes ST-segment elevation ...

Mackay Medical College

Mackay Memorial Hospital

MacKay Junior College of Medicine, Nursing, and Management

Taipei Medical University

Taipei Medical University Bilingual Education Center

Acute myocardial infarction (AMI) is a medical emergency; a missed or delayed diagnosis of this disease may contribute to a poor outcome and even death. Several studies have found elderly patients with AMI have atypical presentations for diagnosis, therefore we undertook this study to determine the risks among the elderly population, especially in female patients.

Do elderly females have a higher risk of acute myocardial infarction? A retrospective analysis of 329 cases at an emergency department.

Accurate diagnosis of acute coronary syndrome (ACS) in a timely fashion is challenging in the elderly population, especially elderly women, who usually exhibit atypical clinical symptoms. A multiple cardiac biomarker (MCB) based approach has been shown to improve diagnostic efficacy of ACS. However, data in various age groups and sex differences remain largely unexplored.

The feasibility and diagnostic accuracy by multiple cardiac biomarkers in emergency chest pain patients: a clinical analysis to compare 290 suspected acute coronary syndrome cases stratified by age and gender in Taiwan.

Dyspnea in pregnancy is common. It can result from adaption to body changes in pregnancy and also from complications therein. Understanding the mechanisms of change in the respiratory system during pregnancy helps with the differential diagnosis of dyspnea in normal pregnancy as opposed to pathological dyspnea.

Dyspnea in pregnancy.

To provide an insight into the challenges faced by the closest hospital to the Formosa Fun Coast Dust Explosion (FFCDE) disaster scene, and to examine how the hospital staff adapted to cope with the mass burn casualty (MBC) in their overcrowded emergency department (ED) after the disaster.

Beyond surge: Coping with mass burn casualty in the closest hospital to the Formosa Fun Coast Dust Explosion.

Sensitization to mites is a considerable factor in the development of allergic diseases. Because of its abundance, Tyrophagus putrescentiae (Tp) is the predominant storage mite found in home storage rooms, kitchens, and bakeries. Patients allergic to mites might exhibit a severely hypersensitive reaction upon ingesting Tp-contaminated food. The objective of this study was to investigate the rates of Tp contamination in commercial storage products from various areas, storage conditions, and environments in Taiwan. A specific antibody against Tyr p 3, the allergen on Tp, could be used as an indicator to monitor the contamination condition in storage foods. The microscopic mite examination, allergen detection by ELISA and cultured mite chemotaxis were used to evaluate the prevalence of T. putrescentiae contamination. Moreover, the IgE responses of patients allergic to mites were examined. We found that pet food and mushrooms were commonly contaminated with Tp, and this was validated through Tyr p 3 concentration and chemotaxis experiments. Tp contamination rates decreased significantly when samples were sealed and stored at a low temperature (<  4 °C), low relative humidity (RH < 60%), or for longer periods at a low temperature. The results of the clinical study indicated that the mites that elicited major positive IgE responses in allergic subjects were Dermatophagoides pteronyssinus and D. farinae. Thus, people who are sensitized to D. pteronyssinus or D. farinae might be at risk of a second anaphylactic reaction due to cross-reactivity upon ingestion of Tp-contaminated food. Accordingly, Tp contamination can be prevented by keeping food packages sealed and stored at a low temperature. This prevents the severe allergic reaction caused by the inadvertent ingestion of contaminated food-borne Tp.

Influence of storage conditions on the infestation of Tyrophagus putrescentiae and prevalence of mite hypersensitivity in Taiwan.

Ultra-marathons are typically held over harsh terrains such as mountains, deserts, or other wilderness, and place severe demands on the physical and psychological capabilities of participants. Adventure-race competitors commonly report hallucinations. The goal of this study was to gain insight into visual hallucinations (VHs) during a mountain ultra-marathon. Thirty-one Taiwanese runners who participated in the 2018 Run Across Taiwan Ultra-Marathon, which spans 246 km with an altitude difference of 3266 m and an overall cut-off time of 44 h, volunteered for this study. Self-reported questionnaires on sleep duration, hallucinatory experiences, clinical symptoms of cold- and heat-related illnesses, and the 2018 Lake Louise Acute Mountain Sickness (AMS) Score were recorded prerace, during the summit, immediately postrace, and 3-days postrace. Hematological samples were collected 1 week before, immediately after, and 3 days after the race. Eight ultra-marathoners (six males and two females; seven finishers and one withdrawer) were recruited. Three out of eight (37.5%) subjects (two males and one female) reported experiencing VHs during the last 60 km. Three out of five (60%) lower-ranked subjects experienced VHs. All eight runners slept for <30 min during the race. None of the runners presented with headache either during or after the race to meet the criteria for AMS. None of the runners suffered an abnormal thermoregulatory response or a hypoglycemic episode throughout the ultra-marathon. The changes in blood osmolality immediately postrace were subclinical, despite being statistically significant. Among the three runners with VHs, none presented with severe dehydration or dysnatremia immediately postrace. High-altitude exposure, hyper/hypothermia, dehydration, dysnatermia, or hypoglycemia did not seem to contribute to hallucination onset in our subjects during the event. VHs of ultra-marathoners may be associated with excessive physical exertion and sleep deprivation.

Visual hallucinations in 246-km mountain ultra-marathoners: An observational study.

Lethal intercostal artery injury after a fall.

Chest pain in six Taiwanese teenagers at high altitudes.

Point-of-care assessments and the occurrence of asymptomatic pulmonary edema in a healthy Taiwanese trekker at high altitudes.

Performance evaluation of Panbio COVID-19 rapid antigen test for SARS-CoV-2 detection in a low prevalence cohort.

The diagnosis of acute mountain sickness, which lacks a reliable and objective diagnostic tool, still depends on the clinical symptoms and signs and remains a major threat and unpredictable disease affecting millions of mountaineers.

Article	Year
Do elderly females have a higher risk of acute myocardial infarction? A retrospective analysis of 329 cases at an emergency department. Taiwanese journal of obstetrics & gynecology\| PubMed ID: 27590383	2016
The feasibility and diagnostic accuracy by multiple cardiac biomarkers in emergency chest pain patients: a clinical analysis to compare 290 suspected acute coronary syndrome cases stratified... BMC cardiovascular disorders\| PubMed ID: 27717317	2016
Dyspnea in pregnancy. Taiwanese journal of obstetrics & gynecology\| PubMed ID: 28805596	2017
Beyond surge: Coping with mass burn casualty in the closest hospital to the Formosa Fun Coast Dust Explosion. Burns : journal of the International Society for Burn Injuries\| PubMed ID: 30598266	2019
Influence of storage conditions on the infestation of Tyrophagus putrescentiae and prevalence of mite hypersensitivity in Taiwan. Experimental & applied acarology\| PubMed ID: 32030607	2020
Visual hallucinations in 246-km mountain ultra-marathoners: An observational study. The Chinese journal of physiology\| PubMed ID: 34708714	2021
Lethal intercostal artery injury after a fall. Quantitative imaging in medicine and surgery\| PubMed ID: 35284260	2022
Chest pain in six Taiwanese teenagers at high altitudes. Journal of travel medicine\| PubMed ID: 35442441	2022
Point-of-care assessments and the occurrence of asymptomatic pulmonary edema in a healthy Taiwanese trekker at high altitudes. Travel medicine and infectious disease\| PubMed ID: 35568140	2022
Performance evaluation of Panbio COVID-19 rapid antigen test for SARS-CoV-2 detection in a low prevalence cohort. Infectious diseases (London, England)\| PubMed ID: 35837988	2022
The changes of electroencephalography in mountaineers on Mount Jade, Taiwan: An observational study. PloS one\| PubMed ID: 36417369	2022

Ding-Kuo Chien

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