synthesis-graphene-hydroxyapatite-nanocomposites-for-potential-use

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Developing novel materials for bone tissue engineering is one of the most important thrust areas of nanomedicine. Several nanocomposites have been ...

Kasetsart University

RK. University

Northeastern University

Copper nanoparticles (CuNPs) and palladium nanoparticles (PdNPs) have attracted wide attention owing to their multifaceted utility in catalysis, sensors, and biomedical applications. Their therapeutic spectrum includes anticancer, antiviral, antibacterial, antifungal, antidiabetic, antioxidant potential which rationalizes the exploration of diverse physical, chemical, and biological routes for fabrication. In this article, we focused on bacterium-assisted design of nanostructured copper and palladium for applications in therapy against multidrug-resistant pathogens, dehalogenation of diatrizoate, Heck coupling of iodobenzene, polymer electric membrane fuel cell, metal recovery, and electronic waste management. Further, hypothesis behind microbial synthesis of PdNPs in E. coli containing [NiFe] hydrogenase Hyd-1 is discussed. Similarly, detailed mechanism of synthesis and stabilization in Cyanobacteria is also documented. Both CuNPs and PdNPs act as potent chemotherapeutic agents that can further be enhanced by conjugation with drugs and/or fluorophores and ligands for simultaneous diagnosis and targeted drug delivery to the cancer site or infection. These bacteriogenic nanoparticles can be used in sensors and pollution control.

Copper and palladium nanostructures: a bacteriogenic approach.

Increasing resistance to available drugs and their associated side-effects have drawn wide attention towards designing alternative therapeutic strategies for control of hyperglycemia and oxidative stress. The roles of the sizes and shapes of the nanomaterials used in the treatment and management of Type 2 Diabetes Mellitus (T2DM) in preventing chronic hyperglycaemia and oxidative stress are investigated. We report specifically on the effects of doping silver (Ag) into the ZnO nanorods (ZnO:Ag NR's) as a rational drug designing strategy.

Effect of silver doping on antidiabetic and antioxidant potential of ZnO nanorods.

Photosynthetic microbes like brown algae, red algae, green-algae and blue-green algae (cyanobacteria) are utilized extensively for various commercial and industrial purposes. However, in recent time, their application has shifted to nanotechnology. The synthesis of metal nanoparticles using algal resources is known as Phyconanotechnology. Due to various advantages of the photosynthetic microbes such as presence of bioactive molecules, scalability, high metal uptake and cultivability, these microbes form ideal sources for nanoparticle synthesis. The green synthesis of nanoparticles is a non-toxic and environment-friendly alternative compared to other hazardous chemical and physical routes of synthesis. Several species of algae are explored for the fabrication of metal and metal oxide nanoparticles. Various physical characterization techniques collectively contribute in defining the surface morphology of nanoparticles and the existing functional groups for bioreduction and stability. A wide range of nanostructured metals like gold, silver, copper, zinc, iron, platinum and palladium are fabricated using algae and cyanobacteria. Due to the unique properties of the phycogenic nanoparticles, biocompatibility and safety aspects, all of these metal nanoparticles have their applications in facets like infection control, diagnosis, drug delivery, biosensing and bioremediation. Herein, the uniqueness of the phycogenic nanoparticles along with their distinctive antibacterial, antifungal, antibiofilm, algaecidal, antiviral, anticancer, antioxidant, antidiabetic, dye degradation, metal removal and catalytic properties are featured. Lastly, this work highlights the various challenges and future perspectives for further exploration of the biogenic metal nanoparticles for development of nanomedicine and environmental remediation in the coming years.

Article	Year
Copper and palladium nanostructures: a bacteriogenic approach. Applied microbiology and biotechnology\| PubMed ID: 29998411	2018
Effect of silver doping on antidiabetic and antioxidant potential of ZnO nanorods. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)\| PubMed ID: 31901726	2020
Photosynthetic microbes in nanobiotechnology: Applications and perspectives. The Science of the total environment\| PubMed ID: 35662597	2022

Sougata Ghosh

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