David T. Breault

Boston Children’s Hospital, Harvard Medical School

Affiliated withHarvard Medical School Boston Children's Hospital Harvard Stem Cell Institute

Research Area

Biography

David Breault, MD, PhD is a physician-scientists and pediatric endocrinologist at Boston CHildren's Hospital and Harvard Medical School. He is the Associate Chief of the Division of Endocrinology at Boston Children's Hospital and an Associate Professor of Pediatrics at Harvard Medical School. He is a Principal Faculty member of the Harvard Stem Cell Institute and an Affiliate Faculty member of the Department of Stem Cell and Regenerative Biology at Harvard University. He obtained his MD and PhD from the University of Connecticut School of Medicine and pediatric training at Yale-New Haven Hospital.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 2	2022
Publication title	2026

Other Publications

Article	Year
Small intestinal stem cell markers. Journal of anatomy\| PubMed ID: 18638070	2008
Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18650388	2008
Regulation of gene expression in the intestinal epithelium. Progress in molecular biology and translational science\| PubMed ID: 21075346	2010
Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21173232	2011
Characterization and fate of telomerase-expressing epithelia during kidney repair. Journal of the American Society of Nephrology : JASN\| PubMed ID: 22021716	2011
Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell stem cell\| PubMed ID: 22226346	2012
Optimised protocols for the identification of the murine cardiac side population. Stem cell reviews\| PubMed ID: 23619929	2013
Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Developmental cell\| PubMed ID: 24035414	2013
Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem cell research\| PubMed ID: 26079371	2015
Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem cell reports\| PubMed ID: 26489894	2015
Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell reports\| PubMed ID: 26686631	2015
The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Molecular human reproduction\| PubMed ID: 26740067	2016
Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell stem cell\| PubMed ID: 26908146	2016
An enduring role for quiescent stem cells. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 27153394	2016
Regulation of zonation and homeostasis in the adrenal cortex. Molecular and cellular endocrinology\| PubMed ID: 27619404	2017
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature\| PubMed ID: 27680706	2016
CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome biology\| PubMed ID: 27687735	2016
The Circadian Clock Gene Coordinates Intestinal Regeneration. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 28593182	2017
Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem cells (Dayton, Ohio)\| PubMed ID: 28913973	2018
JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem cell reports\| PubMed ID: 29276155	2018
PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI insight\| PubMed ID: 29367455	2018
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Scientific reports\| PubMed ID: 29440725	2018
The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS biology\| PubMed ID: 29596476	2018
Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 29599138	2018
Adrenocortical development: Lessons from mouse models. Annales d'endocrinologie\| PubMed ID: 29673697	2018
Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29713662	2018
Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. American journal of human genetics\| PubMed ID: 29909964	2018
High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal immunology\| PubMed ID: 30111863	2018
The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology\| PubMed ID: 30321360	2018
Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 30580687	2019
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome\| PubMed ID: 30890187	2019
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nature biomedical engineering\| PubMed ID: 31086325	2019
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nature microbiology\| PubMed ID: 31160825	2019
Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nature biomedical engineering\| PubMed ID: 31213704	2019
Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology\| PubMed ID: 31398249	2019
Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. The Journal of clinical investigation\| PubMed ID: 31738186	2020
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 31778828	2020
Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PloS one\| PubMed ID: 32240190	2020
β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nature communications\| PubMed ID: 32245949	2020
Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell reports\| PubMed ID: 32320669	2020
Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials\| PubMed ID: 32502894	2020
Wnt/β-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene\| PubMed ID: 32561853	2020
Organoid culture system for patient-derived lung metastatic osteosarcoma. Medical oncology (Northwood, London, England)\| PubMed ID: 33079257	2020
Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-α Induced Injury. Cellular and molecular bioengineering\| PubMed ID: 33184579	2020
Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 33438789	2021
Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive in continuous culture. Med (New York, N.Y.)\| PubMed ID: 33511375	2021
Rosette morphology in zona glomerulosa formation and function. Molecular and cellular endocrinology\| PubMed ID: 33891993	2021
Coculture of primary human colon monolayer with human gut bacteria. Nature protocols\| PubMed ID: 34183870	2021
Rapid Prototyping of Multilayer Microphysiological Systems. ACS biomaterials science & engineering\| PubMed ID: 34275297	2021
Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. Gut microbes\| PubMed ID: 34793276	2021
Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nature communications\| PubMed ID: 35017529	2022
Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling. Current protocols\| PubMed ID: 35030297	2022
Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell\| PubMed ID: 35259335	2022
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. Lab on a chip\| PubMed ID: 35274118	2022
A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nature communications\| PubMed ID: 35314684	2022
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem cells (Dayton, Ohio)\| PubMed ID: 35511869	2022
Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease. Gut\| PubMed ID: 35537812	2022