Robert M. Graham

Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute

Affiliated withVictor Chang Cardiac Research Institute University of New South Wales Sydney

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation. Biochemistry\| PubMed ID: 11781098	2002
Mutation of a single TMVI residue, Phe(282), in the beta(2)-adrenergic receptor results in structurally distinct activated receptor conformations. Biochemistry\| PubMed ID: 11993999	2002
Molecular mechanisms of inherited cardiomyopathies. Physiological reviews\| PubMed ID: 12270949	2002
Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14566064	2003
Involvement of chymase-mediated angiotensin II generation in blood pressure regulation. The Journal of clinical investigation\| PubMed ID: 15232618	2004
Molecular basis of exopeptidase activity in the C-terminal domain of human angiotensin I-converting enzyme: insights into the origins of its exopeptidase activity. The Journal of biological chemistry\| PubMed ID: 15615692	2005
The alpha(1D)-adrenergic receptor: cinderella or ugly stepsister. Molecular pharmacology\| PubMed ID: 16246907	2006
Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity. The Journal of biological chemistry\| PubMed ID: 16522628	2006
Cross-linking transglutaminases with G protein-coupled receptor signaling. Science's STKE : signal transduction knowledge environment\| PubMed ID: 16985237	2006
Profound thrombocytopenia related to G-CSF. American journal of hematology\| PubMed ID: 17034024	2007
Actions and therapeutic potential of G-CSF and GM-CSF in cardiovascular disease. Journal of molecular and cellular cardiology\| PubMed ID: 17109881	2007
Mechanism of allosteric regulation of transglutaminase 2 by GTP. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17179049	2006
Wide turn diversity in protein transmembrane helices implications for G-protein-coupled receptor and other polytopic membrane protein structure and function. Molecular pharmacology\| PubMed ID: 18202304	2008
Safety and efficacy of consecutive cycles of granulocyte-colony stimulating factor, and an intracoronary CD133+ cell infusion in patients with chronic refractory ischemic heart disease: the ... American heart journal\| PubMed ID: 19061712	2008
Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders. Physiological reviews\| PubMed ID: 19584319	2009
Reproducibility of adenosine stress cardiovascular magnetic resonance in multi-vessel symptomatic coronary artery disease. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 20663155	2010
The elusive π-helix. Journal of structural biology\| PubMed ID: 20828621	2011
A recombinant human neuregulin-1 peptide improves preservation of the rodent heart after prolonged hypothermic storage. Transplantation\| PubMed ID: 21364498	2011
Regulation of murine cardiac contractility by activation of α(1A)-adrenergic receptor-operated Ca(2+) entry. Cardiovascular research\| PubMed ID: 21546445	2011
The ontogeny of cardiac regeneration. Circulation research\| PubMed ID: 21617133	2011
Granulocyte colony stimulating factor in chronic angina to stimulate neovascularisation: a placebo controlled crossover trial. Heart (British Cardiac Society)\| PubMed ID: 22115984	2012
Functional Characterization of a Novel Mutation in NKX2-5 Associated with Congenital Heart Disease and Adult-Onset Cardiomyopathy. Circulation. Cardiovascular genetics\| PubMed ID: 23661673	2013
Glucose homeostasis in mice is transglutaminase 2 independent. PloS one\| PubMed ID: 23717413	2013
A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell\| PubMed ID: 24813607	2014
RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility. PloS one\| PubMed ID: 24919197	2014
Thyroid hormone action in postnatal heart development. Stem cell research\| PubMed ID: 25087894	2014
Introduction to the special issue on heart regeneration and rejuvenation. Stem cell research\| PubMed ID: 25459518	2014
Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period. Journal of the American College of Cardiology\| PubMed ID: 25677315	2015
Rapid Knockout and Reporter Mouse Line Generation and Breeding Colony Establishment Using EUCOMM Conditional-Ready Embryonic Stem Cells: A Case Study. Frontiers in endocrinology\| PubMed ID: 26175717	2015
Overexpression of Cardiomyocyte α1A-Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular Signaling. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 26338300	2015
Cardiac Regeneration Therapies - Targeting Neuregulin 1 Signalling. Heart, lung & circulation\| PubMed ID: 26476583	2016
Cardiomyocytes Replicate and their Numbers Increase in Young Hearts. Cell\| PubMed ID: 26544928	2015
Heterologously-expressed and Liposome-reconstituted Human Transient Receptor Potential Melastatin 4 Channel (TRPM4) is a Functional Tetramer. Scientific reports\| PubMed ID: 26785754	2016
Identifying ligands at orphan GPCRs: current status using structure-based approaches. British journal of pharmacology\| PubMed ID: 26837045	2016
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of molecular and cellular cardiology\| PubMed ID: 27021517	2016
Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PloS one\| PubMed ID: 27050167	2016
Metalloprotease cleavage of the N terminus of the orphan G protein-coupled receptor GPR37L1 reduces its constitutive activity. Science signaling\| PubMed ID: 27072655	2016
IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27274047	2016
Gestational stress induces the unfolded protein response, resulting in heart defects. Development (Cambridge, England)\| PubMed ID: 27436040	2016
Outcomes of patients with spontaneous coronary artery dissection. Open heart\| PubMed ID: 27621835	2016
Angiotensin type 2-receptor (AT2R) activation induces hypotension in apolipoprotein E-deficient mice by activating peroxisome proliferator-activated receptor-γ. American journal of cardiovascular disease\| PubMed ID: 27679746	2016
Pathophysiological Trends During Withdrawal of Life Support: Implications for Organ Donation After Circulatory Death. Transplantation\| PubMed ID: 27861290	2016
Orphan receptor ligand discovery by pickpocketing pharmacological neighbors. Nature chemical biology\| PubMed ID: 27992882	2017
The Mystery and Enigma of Spontaneous Coronary Artery Dissection. Heart, lung & circulation\| PubMed ID: 29501270	2018
A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data. Circulation. Genomic and precision medicine\| PubMed ID: 29555671	2018
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control. Biology of sex differences\| PubMed ID: 29625592	2018
Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice. Scientific reports\| PubMed ID: 29666426	2018
Identification of clinically actionable variants from genome sequencing of families with congenital heart disease. Genetics in medicine : official journal of the American College of Medical Genetics\| PubMed ID: 30293987	2019
Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. Journal of the American College of Cardiology\| PubMed ID: 30621952	2019
The Australian Cardiovascular Alliance-Towards an Integrated Whole-of-Nation Strategy to Address Our Major Health Burden. Heart, lung & circulation\| PubMed ID: 30654944	2019
A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia. PloS one\| PubMed ID: 30943188	2019
Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection. Stem cell research\| PubMed ID: 31707208	2019
Redox activation of JNK2α2 mediates thyroid hormone-stimulated proliferation of neonatal murine cardiomyocytes. Scientific reports\| PubMed ID: 31776360	2019
Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction. Science translational medicine\| PubMed ID: 31894101	2020
Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women. Heart, lung & circulation\| PubMed ID: 32713767	2021
Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation. Frontiers in immunology\| PubMed ID: 32793209	2020
Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes. Scientific reports\| PubMed ID: 32948799	2020
Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing. Circulation. Genomic and precision medicine\| PubMed ID: 33125268	2020
The N-terminus of GPR37L1 is proteolytically processed by matrix metalloproteases. Scientific reports\| PubMed ID: 33203955	2020
DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling. Scientific reports\| PubMed ID: 33318551	2020
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner. Frontiers in pharmacology\| PubMed ID: 33633567	2020
Adaptation to exercise-induced stress is not dependent on cardiomyocyte α-adrenergic receptors. Journal of molecular and cellular cardiology\| PubMed ID: 33647309	2021
Retraction Note: Orphan receptor ligand discovery by pickpocketing pharmacological neighbors. Nature chemical biology\| PubMed ID: 33649604	2021
Cardiac Gq Receptors and Calcineurin Activation Are Not Required for the Hypertrophic Response to Mechanical Left Ventricular Pressure Overload. Frontiers in cell and developmental biology\| PubMed ID: 33659256	2021
Thyroid hormone plus dual-specificity phosphatase-5 siRNA increases the number of cardiac muscle cells and improves left ventricular contractile function in chronic doxorubicin-injured heart... Theranostics\| PubMed ID: 33754028	2021
Everolimus for the Prevention of Calcineurin-Inhibitor-Induced Left Ventricular Hypertrophy After Heart Transplantation (RADTAC Study). JACC. Heart failure\| PubMed ID: 33795116	2021
The Ca-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy. eLife\| PubMed ID: 34190686	2021
Involvement of GPR37L1 in murine blood pressure regulation and human cardiac disease pathophysiology. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 34533400	2021
Mechanism-Based Cardiac Regeneration Strategies in Mammals. Frontiers in cell and developmental biology\| PubMed ID: 34708043	2021
Vascular Stiffness in Aging and Disease. Frontiers in physiology\| PubMed ID: 34950048	2021
Accuracy of vascular tortuosity measures using computational modelling. Scientific reports\| PubMed ID: 35039557	2022
Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing. Circulation. Genomic and precision medicine\| PubMed ID: 35583931	2022
Remuscularization with triiodothyronine and β-blocker therapy reverses post-ischemic left ventricular dysfunction and adverse remodeling. Scientific reports\| PubMed ID: 35614155	2022
Cardiovascular Magnetic Resonance for Rejection Surveillance After Cardiac Transplantation. Circulation\| PubMed ID: 35621277	2022
Adverse events after spontaneous coronary artery dissection. Heart (British Cardiac Society)\| PubMed ID: 35641180	2022
Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts. Journal of molecular and cellular cardiology\| PubMed ID: 35644482	2022