Leon J. Schurgers

Department of Biochemistry, Maastricht University

Affiliated withMaastricht University RWTH Aachen University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochimica et biophysica acta\| PubMed ID: 11960685	2002
Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men. Journal of lipid research\| PubMed ID: 12032162	2002
Characteristics and performance of an immunosorbent assay for human matrix Gla-protein. Clinica chimica acta; international journal of clinical chemistry\| PubMed ID: 15563881	2005
Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15961706	2005
Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats. Blood\| PubMed ID: 17138823	2007
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. Journal of vascular research\| PubMed ID: 18401181	2008
Anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in APOE2 knock-in mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 18757293	2008
Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thrombosis and haemostasis\| PubMed ID: 18841280	2008
Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. Thrombosis and haemostasis\| PubMed ID: 19190822	2009
Association of kidney function and uncarboxylated matrix Gla protein: data from the Heart and Soul Study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 19204017	2009
The association of uncarboxylated matrix Gla protein with mitral annular calcification differs by diabetes status: The Heart and Soul study. Atherosclerosis\| PubMed ID: 20015492	2010
Chronic coumarin treatment is associated with increased extracoronary arterial calcification in humans. Blood\| PubMed ID: 20354170	2010
The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Annals of internal medicine\| PubMed ID: 20479029	2010
Calcium scores and matrix Gla protein levels: association with vitamin K status. European journal of clinical investigation\| PubMed ID: 20486996	2010
Characterisation and potential diagnostic value of circulating matrix Gla protein (MGP) species. Thrombosis and haemostasis\| PubMed ID: 20694284	2010
Arterial calcifications. Journal of cellular and molecular medicine\| PubMed ID: 20716128	2010
Circulating nonphosphorylated carboxylated matrix gla protein predicts survival in ESRD. Journal of the American Society of Nephrology : JASN\| PubMed ID: 21289218	2011
Microcalcifications in early intimal lesions of atherosclerotic human coronary arteries. The American journal of pathology\| PubMed ID: 21531376	2011
Vitamin K supplementation increases vitamin K tissue levels but fails to counteract ectopic calcification in a mouse model for pseudoxanthoma elasticum. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 21725681	2011
Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients. European heart journal\| PubMed ID: 21775389	2011
Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. The British journal of nutrition\| PubMed ID: 22136751	2012
Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects. The British journal of nutrition\| PubMed ID: 22289649	2012
Vitamin K intake and status are low in hemodialysis patients. Kidney international\| PubMed ID: 22648294	2012
Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype. PloS one\| PubMed ID: 22952653	2012
Molecular imaging to identify the vulnerable plaque--from basic research to clinical practice. Molecular imaging and biology\| PubMed ID: 22983911	2012
Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. Journal of the American Chemical Society\| PubMed ID: 23066897	2012
Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients. PloS one\| PubMed ID: 23118917	2012
Mechanisms of arterial remodeling: lessons from genetic diseases. Frontiers in genetics\| PubMed ID: 23248645	2012
Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization. Trends in molecular medicine\| PubMed ID: 23375872	2013
Vitamin K: key vitamin in controlling vascular calcification in chronic kidney disease. Kidney international\| PubMed ID: 23633049	2013
The realm of vitamin K dependent proteins: shifting from coagulation toward calcification. Molecular nutrition & food research\| PubMed ID: 24668744	2014
AnxA5 reduces plaque inflammation of advanced atherosclerotic lesions in apoE(-/-) mice. Journal of cellular and molecular medicine\| PubMed ID: 25214012	2014
Differential cellular effects of old and new oral anticoagulants: consequences to the genesis and progression of atherosclerosis. Thrombosis and haemostasis\| PubMed ID: 25298033	2014
Vascular smooth muscle cell calcification is mediated by regulated exosome secretion. Circulation research\| PubMed ID: 25711438	2015
Prevention of vasculopathy by vitamin K supplementation: can we turn fiction into fact? Atherosclerosis\| PubMed ID: 25744701	2015
Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PloS one\| PubMed ID: 26090792	2015
High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification. Nutrients\| PubMed ID: 26295257	2015
What's in a name? The pharmacy of vitamin K. British journal of haematology\| PubMed ID: 26492096	2016
Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial). Nutrients\| PubMed ID: 26516910	2015
Intra-Section Analysis of Human Coronary Arteries Reveals a Potential Role for Micro-Calcifications in Macrophage Recruitment in the Early Stage of Atherosclerosis. PloS one\| PubMed ID: 26555788	2015
New Insights into the Pros and Cons of the Clinical Use of Vitamin K Antagonists (VKAs) Versus Direct Oral Anticoagulants (DOACs). Nutrients\| PubMed ID: 26593943	2015
Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice. PloS one\| PubMed ID: 27636705	2016
Does statins promote vascular calcification in chronic kidney disease? European journal of clinical investigation\| PubMed ID: 28036114	2017
Slower Progress of Aortic Valve Calcification With Vitamin K Supplementation: Results From a Prospective Interventional Proof-of-Concept Study. Circulation\| PubMed ID: 28533322	2017
Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype. Journal of extracellular vesicles\| PubMed ID: 28717419	2017
Calcific aortic valve stenosis: hard disease in the heart: A biomolecular approach towards diagnosis and treatment. European heart journal\| PubMed ID: 29136138	2018
Use of Cyclic Backbone NGR-Based SPECT to Increase Efficacy of Postmyocardial Infarction Angiogenesis Imaging. Contrast media & molecular imaging\| PubMed ID: 29204107	2017
Desphospho-Uncarboxylated Matrix-Gla Protein Is Increased Postoperatively in Cardiovascular Risk Patients. Nutrients\| PubMed ID: 29303985	2018
Influence of pH and phosphate concentration on the phosphate binding capacity of five contemporary binders. An in vitro study. Nephrology (Carlton, Vic.)\| PubMed ID: 29479762	2019
Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design. Nutrients\| PubMed ID: 29561783	2018
Ucma/GRP inhibits phosphate-induced vascular smooth muscle cell calcification via SMAD-dependent BMP signalling. Scientific reports\| PubMed ID: 29563538	2018
Decreased Levels of Circulating Carboxylated Osteocalcin in Children with Low Energy Fractures: A Pilot Study. Nutrients\| PubMed ID: 29882816	2018
A Novel Biomimetic Tool for Assessing Vitamin K Status Based on Molecularly Imprinted Polymers. Nutrients\| PubMed ID: 29891757	2018
Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome. Experimental and molecular pathology\| PubMed ID: 29981754	2018
Missense mutation of VKORC1 leads to medial arterial calcification in rats. Scientific reports\| PubMed ID: 30214074	2018
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the hori... European journal of nuclear medicine and molecular imaging\| PubMed ID: 30302506	2019
Vitamin K deficiency in critical ill patients; a prospective observational study. Journal of critical care\| PubMed ID: 30415179	2019
Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults. Nutrients\| PubMed ID: 30678199	2019
Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy. Journal of clinical medicine\| PubMed ID: 30682787	2019
Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. International journal of molecular sciences\| PubMed ID: 30791399	2019
The Bone-Vasculature Axis: Calcium Supplementation and the Role of Vitamin K. Frontiers in cardiovascular medicine\| PubMed ID: 30805347	2019
Targeting Coagulation Factor Xa Promotes Regression of Advanced Atherosclerosis in Apolipoprotein-E Deficient Mice. Scientific reports\| PubMed ID: 30846818	2019
Vitamin K Antagonists, Non-Vitamin K Antagonist Oral Anticoagulants, and Vascular Calcification in Patients with Atrial Fibrillation. TH open : companion journal to thrombosis and haemostasis\| PubMed ID: 31249966	2018
A Combination of seeds and Rhizome Extracts Improves Knee Joint Function and Alleviates Pain in Non-Arthritic Adults Following Physical Activity. International journal of medical sciences\| PubMed ID: 31337958	2019
Pharmacological and Nutritional Modulation of Vascular Calcification. Nutrients\| PubMed ID: 31905884	2019
Vitamin K Antagonist Use and Risk for Intracranial Carotid Artery Calcification in Patients With Intracerebral Hemorrhage. Frontiers in neurology\| PubMed ID: 31920910	2019
Cheese and Healthy Diet: Associations With Incident Cardio-Metabolic Diseases and All-Cause Mortality in the General Population. Frontiers in nutrition\| PubMed ID: 31921878	2019
Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease. Journal of clinical medicine\| PubMed ID: 32102408	2020
Early vascular ageing in chronic kidney disease: impact of inflammation, vitamin K, senescence and genomic damage. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 32162665	2020
Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease. Scientific reports\| PubMed ID: 32313061	2020
Sevelamer Use in End-Stage Kidney Disease (ESKD) Patients Associates with Poor Vitamin K Status and High Levels of Gut-Derived Uremic Toxins: A Drug-Bug Interaction? Toxins\| PubMed ID: 32471179	2020
Intimal and medial calcification in relation to cardiovascular risk factors. PloS one\| PubMed ID: 32658909	2020
Biomarkers Associated With Aortic Valve Calcification: Should We Focus on Sex Specific Processes? Frontiers in cell and developmental biology\| PubMed ID: 32754594	2020
Combined low vitamin D and K status amplifies mortality risk: a prospective study. European journal of nutrition\| PubMed ID: 32808059	2021
Reduced Vitamin K Status as a Potentially Modifiable Risk Factor of Severe Coronavirus Disease 2019. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America\| PubMed ID: 32852539	2021
Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78 (Glucose-Regulated Protein, 78 kDa)-Loaded Extracellular Vesicles. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 33297752	2021
Functional vitamin K status and risk of incident chronic kidney disease and microalbuminuria: a prospective general population-based cohort study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 33313895	2021
γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K-dependent proteins. Blood\| PubMed ID: 33507293	2021
Sodium [F]Fluoride PET Can Efficiently Monitor In Vivo Atherosclerotic Plaque Calcification Progression and Treatment. Cells\| PubMed ID: 33573188	2021
Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells. Frontiers in cell and developmental biology\| PubMed ID: 33585456	2020
Locking and loading the bullet against micro-calcification. European journal of preventive cardiology\| PubMed ID: 33611501	2020
Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study. PloS one\| PubMed ID: 33626087	2021
Off-target effects of oral anticoagulants - vascular effects of vitamin K antagonist and non-vitamin K antagonist oral anticoagulant dabigatran etexilate. Journal of thrombosis and haemostasis : JTH\| PubMed ID: 33687782	2021
Effects of Combined Vitamin K2 and Vitamin D3 Supplementation on Na[F]F PET/MRI in Patients with Carotid Artery Disease: The INTRICATE Rationale and Trial Design. Nutrients\| PubMed ID: 33808652	2021
Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling. Cardiovascular research\| PubMed ID: 33913468	2022
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification. Cells\| PubMed ID: 34063989	2021
Vitamin K and cardiovascular complications in chronic kidney disease patients. Kidney international\| PubMed ID: 34310988	2021
Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity. Cells\| PubMed ID: 34440866	2021
Hepatic and Vascular Vitamin K Status in Patients with High Cardiovascular Risk. Nutrients\| PubMed ID: 34684491	2021
Combining phosphate binder therapy with vitamin K2 inhibits vascular calcification in an experimental animal model of kidney failure. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 34718756	2022
Vitamin K-a neglected player in cardiovascular health: a narrative review. Open heart\| PubMed ID: 34785587	2021
Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity. Frontiers in medicine\| PubMed ID: 35004784	2021
Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells. International journal of molecular sciences\| PubMed ID: 35054772	2022
Improved Quantification of Cell Density in the Arterial Wall-A Novel Nucleus Splitting Approach Applied to 3D Two-Photon Laser-Scanning Microscopy. Frontiers in physiology\| PubMed ID: 35095571	2021
Dietary magnesium supplementation inhibits abdominal vascular calcification in an experimental animal model of chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association\| PubMed ID: 35134986	2022
Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is the Evidence? Current vascular pharmacology\| PubMed ID: 35139790	2022
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification. Clinical and translational medicine\| PubMed ID: 35184400	2022
Prenatal administration of multipotent adult progenitor cells modulates the systemic and cerebral immune response in an ovine model of chorioamnionitis. Brain, behavior, & immunity - health\| PubMed ID: 35647567	2022