lipid-supplementation-for-longevity-gene-transcriptional-analysis

Lipid Supplementation for Longevity and Gene Transcriptional Analysis in <em>Caenorhabditis elegans</em>

Aging is a complex process characterized by progressive physiological changes resulting from both environmental and genetic contributions. Lipids are ...

Baylor College of Medicine

Bacterial avoidance and innate immune response are two ways by which C. elegans respond to pathogenic bacteria. In this issue of Developmental Cell, Kumar et al. (2019) and Singh and Aballay (2019) demonstrate that bacterial colonization is essential to induce both responses, which may be associated with somatic and reproductive longevity.

The Bacterivore's Solution: Fight and Flight to Promote Survival.

Lysosomes are key cellular organelles that metabolize extra- and intracellular substrates. Alterations in lysosomal metabolism are implicated in ageing-associated metabolic and neurodegenerative diseases. However, how lysosomal metabolism actively coordinates the metabolic and nervous systems to regulate ageing remains unclear. Here we report a fat-to-neuron lipid signalling pathway induced by lysosomal metabolism and its longevity-promoting role in Caenorhabditis elegans. We discovered that induced lysosomal lipolysis in peripheral fat storage tissue upregulates the neuropeptide signalling pathway in the nervous system to promote longevity. This cell-non-autonomous regulation is mediated by a specific polyunsaturated fatty acid, dihomo-γ-linolenic acid, and LBP-3 lipid chaperone protein transported from the fat storage tissue to neurons. LBP-3 binds to dihomo-γ-linolenic acid, and acts through NHR-49 nuclear receptor and NLP-11 neuropeptide in neurons to extend lifespan. These results reveal lysosomes as a signalling hub to coordinate metabolism and ageing, and lysosomal signalling mediated inter-tissue communication in promoting longevity.

Article	Year
The Bacterivore's Solution: Fight and Flight to Promote Survival. Developmental cell\| PubMed ID: 30965036	2019
Lysosome lipid signalling from the periphery to neurons regulates longevity. Nature cell biology\| PubMed ID: 35681008	2022

Yi-Tang Lee

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