Juan Fortea

Sant Pau Memory Unit, Universitat Autònoma de Barcelona

Affiliated withUniversitat Autònoma de Barcelona Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED)

Research Area

Neuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 16	2022

Other Publications

Article	Year
Expansion mutation in C9ORF72 does not influence plasma progranulin levels in frontotemporal dementia. Neurobiology of aging\| PubMed ID: 22502998	2012
Characterization of the repeat expansion size in C9orf72 in amyotrophic lateral sclerosis and frontotemporal dementia. Human molecular genetics\| PubMed ID: 24057670	2014
Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PloS one\| PubMed ID: 24069280	2013
Feasibility of lumbar puncture in the study of cerebrospinal fluid biomarkers for Alzheimer's disease: a multicenter study in Spain. Journal of Alzheimer's disease : JAD\| PubMed ID: 24254700	2014
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 24309270	2014
Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation. Journal of Alzheimer's disease : JAD\| PubMed ID: 24503620	2014
Relationship between β-Secretase, inflammation and core cerebrospinal fluid biomarkers for Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 24820015	2014
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science translational medicine\| PubMed ID: 24990881	2014
Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. Neurobiology of aging\| PubMed ID: 25042114	2014
Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion. Alzheimer disease and associated disorders\| PubMed ID: 25203513	2015
Cerebral amyloid angiopathy-related atraumatic convexal subarachnoid hemorrhage: an ARIA before the tsunami. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 25735919	2015
Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study. Neurobiology of aging\| PubMed ID: 25796131	2015
Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease. Neurobiology of aging\| PubMed ID: 25865441	2015
Prevalence of amyloid PET positivity in dementia syndromes: a meta-analysis. JAMA\| PubMed ID: 25988463	2015
Analysis of the CHCHD10 gene in patients with frontotemporal dementia and amyotrophic lateral sclerosis from Spain. Brain : a journal of neurology\| PubMed ID: 26152333	2015
Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease. Neurology\| PubMed ID: 26180139	2015
Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease? Cortex; a journal devoted to the study of the nervous system and behavior\| PubMed ID: 26343344	2015
Greater specificity for cerebrospinal fluid P-tau231 over P-tau181 in the differentiation of healthy controls from Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 26444757	2015
Patterns of Performance on the Modified Cued Recall Test in Spanish Adults With Down Syndrome With and Without Dementia. American journal on intellectual and developmental disabilities\| PubMed ID: 26505869	2015
Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation. Journal of Alzheimer's disease : JAD\| PubMed ID: 26639966	2016
Assessing the role of TUBA4A gene in frontotemporal degeneration. Neurobiology of aging\| PubMed ID: 26675813	2016
Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias. Journal of Alzheimer's disease : JAD\| PubMed ID: 26682689	2016
Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 27239536	2016
Longitudinal brain structural changes in preclinical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 27693189	2017
CSF microRNA Profiling in Alzheimer's Disease: a Screening and Validation Study. Molecular neurobiology\| PubMed ID: 27738874	2017
Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome. Journal of Alzheimer's disease : JAD\| PubMed ID: 27858714	2017
Prevention of dementia, an immediate challenge. Revista clinica espanola\| PubMed ID: 27908380	2016
A Common Variant in the MC1R Gene (p.V92M) is associated with Alzheimer's Disease Risk. Journal of Alzheimer's disease : JAD\| PubMed ID: 28059796	2017
Cerebrospinal fluid mitochondrial DNA in the Alzheimer's disease continuum. Neurobiology of aging\| PubMed ID: 28089353	2017
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28302766	2017
Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 28413821	2017
Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease. Acta neuropathologica\| PubMed ID: 28447221	2017
Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 28463681	2017
Diagnostic and Prognostic Value of the Combination of Two Measures of Verbal Memory in Mild Cognitive Impairment due to Alzheimer's Disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 28527215	2017
CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration. Neurology\| PubMed ID: 28592456	2017
YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer's disease and other tauopathies. Journal of neuroinflammation\| PubMed ID: 28599675	2017
The pitfalls of biomarker-based classification schemes. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 28704640	2017
Analysis of known amyotrophic lateral sclerosis and frontotemporal dementia genes reveals a substantial genetic burden in patients manifesting both diseases not carrying the expansion mutat... Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 28889094	2018
Cortical microstructural changes along the Alzheimer's disease continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 29080407	2018
Synaptic phosphorylated α-synuclein in dementia with Lewy bodies. Brain : a journal of neurology\| PubMed ID: 29177427	2017
Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease. Oncotarget\| PubMed ID: 29285207	2017
Cerebral changes and disrupted gray matter cortical networks in asymptomatic older adults at risk for Alzheimer's disease. Neurobiology of aging\| PubMed ID: 29331877	2018
The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease. PloS one\| PubMed ID: 29415068	2018
The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome. Journal of Alzheimer's disease : JAD\| PubMed ID: 29689719	2018
Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 29780859	2018
Plasma and CSF biomarkers for the diagnosis of Alzheimer's disease in adults with Down syndrome: a cross-sectional study. The Lancet. Neurology\| PubMed ID: 30172624	2018
Challenges associated with biomarker-based classification systems for Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 30175226	2018
Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease. Frontiers in neuroscience\| PubMed ID: 30245615	2018
CSF sAPPβ, YKL-40, and NfL along the ALS-FTD spectrum. Neurology\| PubMed ID: 30291183	2018
Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 30297518	2019
Prevalence of Sleep Disorders in Adults With Down Syndrome: A Comparative Study of Self-Reported, Actigraphic, and Polysomnographic Findings. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine\| PubMed ID: 30353801	2018
Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 30555031	2019
Cortical microstructure in the behavioural variant of frontotemporal dementia: looking beyond atrophy. Brain : a journal of neurology\| PubMed ID: 30906945	2019
Nanoscale structure of amyloid-β plaques in Alzheimer's disease. Scientific reports\| PubMed ID: 30914681	2019
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta neuropathologica\| PubMed ID: 31131421	2019
Exosome release and cargo in Down syndrome. Developmental neurobiology\| PubMed ID: 31347291	2019
Agreement of amyloid PET and CSF biomarkers for Alzheimer's disease on Lumipulse. Annals of clinical and translational neurology\| PubMed ID: 31464088	2019
Assessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review. Journal of neurodevelopmental disorders\| PubMed ID: 31470792	2019
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. Nature communications\| PubMed ID: 31628327	2019
The Sant Pau Initiative on Neurodegeneration (SPIN) cohort: A data set for biomarker discovery and validation in neurodegenerative disorders. Alzheimer's & dementia (New York, N. Y.)\| PubMed ID: 31650016	2019
Detection of amyloid beta peptides in body fluids for the diagnosis of alzheimer's disease: Where do we stand? Critical reviews in clinical laboratory sciences\| PubMed ID: 31661652	2020
APP-derived peptides reflect neurodegeneration in frontotemporal dementia. Annals of clinical and translational neurology\| PubMed ID: 31789459	2019
Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 31799623	2020
Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta neuropathologica\| PubMed ID: 31955222	2020
Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease. Neurology\| PubMed ID: 32291295	2020
Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 32544310	2020
COVID-19-associated ophthalmoparesis and hypothalamic involvement. Neurology(R) neuroimmunology & neuroinflammation\| PubMed ID: 32587102	2020
Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study. Lancet (London, England)\| PubMed ID: 32593336	2020
Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis. Neurology(R) neuroimmunology & neuroinflammation\| PubMed ID: 32669313	2020
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly. Alzheimer's & dementia (Amsterdam, Netherlands)\| PubMed ID: 32743041	2020
Evaluation of biochemical and hematological parameters in adults with Down syndrome. Scientific reports\| PubMed ID: 32792619	2020
Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum. Neurology\| PubMed ID: 32913016	2020
Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 33196147	2021
Nerve growth factor (NGF) pathway biomarkers in Down syndrome prior to and after the onset of clinical Alzheimer's disease: A paired CSF and plasma study. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 33226181	2021
White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers. Journal of Alzheimer's disease : JAD\| PubMed ID: 33252070	2021
Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome. Journal of Alzheimer's disease : JAD\| PubMed ID: 33337378	2021
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature genetics\| PubMed ID: 33589841	2021
Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 33590953	2021
Distinctive Oculomotor Behaviors in Alzheimer's Disease and Frontotemporal Dementia. Frontiers in aging neuroscience\| PubMed ID: 33613262	2020
Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration. JAMA network open\| PubMed ID: 33704477	2021
AMYQ: An index to standardize quantitative amyloid load across PET tracers. Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 33797846	2021
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature communications\| PubMed ID: 34099642	2021
Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 34103344	2021
Epilepsy in Down Syndrome: A Highly Prevalent Comorbidity. Journal of clinical medicine\| PubMed ID: 34202784	2021
Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome. JAMA neurology\| PubMed ID: 34228042	2021
Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome. Nature communications\| PubMed ID: 34262030	2021
Opportunities, barriers, and recommendations in down syndrome research. Translational science of rare diseases\| PubMed ID: 34268067	2021
Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis. Journal of neurology\| PubMed ID: 34272978	2022
Sleep Disorders in Adults with Down Syndrome. Journal of clinical medicine\| PubMed ID: 34300177	2021
Diagnostic and prognostic performance and longitudinal changes in plasma neurofilament light chain concentrations in adults with Down syndrome: a cohort study. The Lancet. Neurology\| PubMed ID: 34302785	2021
Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome. Annals of neurology\| PubMed ID: 34309066	2021
Regional grey matter microstructural changes and volume loss according to disease duration in multiple sclerosis patients. Scientific reports\| PubMed ID: 34413373	2021
Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular psychiatry\| PubMed ID: 34588623	2021
The Clinical and Neuropathological Features of Sporadic (Late-Onset) and Genetic Forms of Alzheimer's Disease. Journal of clinical medicine\| PubMed ID: 34640600	2021
Alzheimer's disease associated with Down syndrome: a genetic form of dementia. The Lancet. Neurology\| PubMed ID: 34687637	2021
Neuropathology of a patient with Alzheimer disease treated with low doses of verubecestat. Neuropathology and applied neurobiology\| PubMed ID: 34825396	2022
Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia. Translational neurodegeneration\| PubMed ID: 34893073	2021
The Aβ1-42/Aβ1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1-42 alone. Alzheimer's research & therapy\| PubMed ID: 35105351	2022
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell metabolism\| PubMed ID: 35108514	2022
Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies. Frontiers in neurology\| PubMed ID: 35115992	2021
Cortical microstructure in primary progressive aphasia: a multicenter study. Alzheimer's research & therapy\| PubMed ID: 35139897	2022
Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles. Journal of neural transmission (Vienna, Austria : 1996)\| PubMed ID: 35169889	2022
Conducting clinical trials in persons with Down syndrome: summary from the NIH INCLUDE Down syndrome clinical trials readiness working group. Journal of neurodevelopmental disorders\| PubMed ID: 35321660	2022
New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature genetics\| PubMed ID: 35379992	2022
Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration. Molecular neurodegeneration\| PubMed ID: 35395770	2022
Feasibility and Long-Term Compliance to Continuous Positive Airway Pressure Treatment in Adults With Down Syndrome, a Genetic Form of Alzheimer's Disease. Frontiers in neuroscience\| PubMed ID: 35431793	2022
Mechanisms Involved in Epileptogenesis in Alzheimer's Disease and Their Therapeutic Implications. International journal of molecular sciences\| PubMed ID: 35457126	2022
Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. JAMA network open\| PubMed ID: 35486397	2022
Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome. JAMA network open\| PubMed ID: 35604690	2022
DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndro... Biomedicines\| PubMed ID: 35740400	2022
Myelin loss in C9orf72 hexanucleotide expansion carriers. Journal of neuroscience research\| PubMed ID: 35766328	2022
Network Tau spreading is vulnerable to the expression gradients of and glutamatergic-related genes. Science translational medicine\| PubMed ID: 35895837	2022