microfluidic-synthesis-microgel-building-blocks-for-microporous

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

The microporous annealed particle (MAP) scaffold platform is a subclass of granular hydrogels. It is composed of an injectable slurry of microgels that ...

University of Virginia

The purpose of this study is to assess the feasibility of a novel microporous annealed particle (MAP) scaffolding hydrogel to enable both articular cartilage and subchondral bone biointegration and chondrocyte regeneration in a rat knee osteochondral defect model.

Injectable Microannealed Porous Scaffold for Articular Cartilage Regeneration.

Microporous annealed particle (MAP) scaffolds consist of a slurry of hydrogel microspheres that undergo annealing to form a solid scaffold. MAP scaffolds have contained functional groups with dual abilities to participate in Michael-type addition (gelation) and radical polymerization (photoannealing). Functional groups with efficient Michael-type additions react with thiols and amines under physiological conditions, limiting usage for therapeutic delivery. We present a heterofunctional maleimide/methacrylamide 4-arm PEG macromer (MethMal) engineered for selective photopolymerization compatible with multiple polymer backbones. Rheology using two classes of photoinitiators demonstrates advantageous photopolymerization capabilities. Functional assays show benefits for therapeutic delivery and 3D printing without impacting cell viability.

Article	Year
Injectable Microannealed Porous Scaffold for Articular Cartilage Regeneration. Annals of plastic surgery\| PubMed ID: 32032122	2020
Selective and Improved Photoannealing of Microporous Annealed Particle (MAP) Scaffolds. ACS biomaterials science & engineering\| PubMed ID: 33423459	2021

Nicholas Cornell

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