Joel S. Greenberger

Department of Radiation Oncology, University of Pittsburgh Cancer Institute

Affiliated withUniversity of Pittsburgh Cancer Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2022

Other Publications

Article	Year
Radioprotection of lung and esophagus by overexpression of the human manganese superoxide dismutase transgene. Military medicine\| PubMed ID: 11873523	2002
Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane. Radiation research\| PubMed ID: 11966323	2002
Prevention of radiation-induced oral cavity mucositis by plasmid/liposome delivery of the human manganese superoxide dismutase (SOD2) transgene. Radiation research\| PubMed ID: 12600239	2003
Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. American journal of respiratory cell and molecular biology\| PubMed ID: 12649121	2003
Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) intratracheal gene therapy reduction of irradiation-induced inflammatory cytokines does not protect orthotopic Lewis lung carcinoma... In vivo (Athens, Greece)\| PubMed ID: 12655784	2003
Overexpression of the transgene for manganese superoxide dismutase (MnSOD) in 32D cl 3 cells prevents apoptosis induction by TNF-alpha, IL-3 withdrawal, and ionizing radiation. Experimental hematology\| PubMed ID: 12829021	2003
Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage. Radiation research\| PubMed ID: 14565825	2003
Correlation of ionizing irradiation-induced late pulmonary fibrosis with long-term bone marrow culture fibroblast progenitor cell biology in mice homozygous deletion recombinant negative for... In vivo (Athens, Greece)\| PubMed ID: 15011745	2004
Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium. Radiation research\| PubMed ID: 15333000	2004
Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In vivo (Athens, Greece)\| PubMed ID: 15369176	2004
In vitro differentiation capacity of esophageal progenitor cells with capacity for homing and repopulation of the ionizing irradiation-damaged esophagus. In vivo (Athens, Greece)\| PubMed ID: 15646807	2004
Increased longevity of hematopoiesis in continuous bone marrow cultures and adipocytogenesis in marrow stromal cells derived from Smad3(-/-) mice. Experimental hematology\| PubMed ID: 15730859	2005
Protection of esophageal multi-lineage progenitors of squamous epithelium (stem cells) from ionizing irradiation by manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) gene therapy. In vivo (Athens, Greece)\| PubMed ID: 16277008	2005
MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus. In vivo (Athens, Greece)\| PubMed ID: 16277013	2005
Thalidomide radiosensitization of normal murine hematopoietic but not squamous cell carcinoma or multiple myeloma tumor cell lines. In vivo (Athens, Greece)\| PubMed ID: 16724666	2006
Increased radioresistance, g(2)/m checkpoint inhibition, and impaired migration of bone marrow stromal cell lines derived from Smad3(-/-) mice. Radiation research\| PubMed ID: 16802867	2006
Bone marrow from CD18-/- (MAC-1-/-) homozygous deletion recombinant negative mice demonstrates increased longevity in long-term bone marrow culture and decreased contribution to irradiation ... In vivo (Athens, Greece)\| PubMed ID: 16900771	2006
Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice. In vivo (Athens, Greece)\| PubMed ID: 17091762	2006
Increased longevity of hematopoiesis in continuous bone marrow cultures derived from NOS1 (nNOS, mtNOS) homozygous recombinant negative mice correlates with radioresistance of hematopoietic ... Experimental hematology\| PubMed ID: 17198882	2007
Effect of EGFR antagonists gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid liposome transgene radiosensitization of a murine squamous cell carcinoma cell line. In vivo (Athens, Greece)\| PubMed ID: 17203769	2006
Effects of MnSOD-plasmid liposome gene therapy on antioxidant levels in irradiated murine oral cavity orthotopic tumors. Radiation research\| PubMed ID: 17316075	2007
Review. Antioxidant gene therapeutic approaches to normal tissue radioprotection and tumor radiosensitization. In vivo (Athens, Greece)\| PubMed ID: 17436562	2007
Overexpression of the MnSOD transgene product protects cryopreserved bone marrow hematopoietic progenitor cells from ionizing radiation. Radiation research\| PubMed ID: 17973554	2007
PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell stem cell\| PubMed ID: 18522850	2008
Radioprotection in vitro and in vivo by minicircle plasmid carrying the human manganese superoxide dismutase transgene. Human gene therapy\| PubMed ID: 18699723	2008
Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells. Molecular biology of the cell\| PubMed ID: 18843049	2008
Modulation of radiation-induced life shortening by systemic intravenous MnSOD-plasmid liposome gene therapy. Radiation research\| PubMed ID: 19024650	2008
Bone marrow-derived stem cells and radiation response. Seminars in radiation oncology\| PubMed ID: 19249651	2009
Mitochondrial targeting of a catalase transgene product by plasmid liposomes increases radioresistance in vitro and in vivo. Radiation research\| PubMed ID: 19580494	2009
Investigation of the effects of aging on homologous recombination in long-term bone marrow cultures. In vivo (Athens, Greece)\| PubMed ID: 19779099	2009
The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. In vivo (Athens, Greece)\| PubMed ID: 19779106	2009
Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy. In vivo (Athens, Greece)\| PubMed ID: 20133969	2010
Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In vivo (Athens, Greece)\| PubMed ID: 20133970	2010
Irradiated esophageal cells are protected from radiation-induced recombination by MnSOD gene therapy. Radiation research\| PubMed ID: 20334517	2010
Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model. In vivo (Athens, Greece)\| PubMed ID: 20668303	2010
Intraesophageal manganese superoxide dismutase-plasmid liposomes ameliorates novel total-body and thoracic radiation sensitivity of NOS1-/- mice. Radiation research\| PubMed ID: 20726721	2010
A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with l... Human gene therapy\| PubMed ID: 20873987	2011
Methyltransferases mediate cell memory of a genotoxic insult. Oncogene\| PubMed ID: 21057543	2011
Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In vivo (Athens, Greece)\| PubMed ID: 21164038	2010
Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy. Gene therapy\| PubMed ID: 21248791	2011
Development of small-molecule PUMA inhibitors for mitigating radiation-induced cell death. Current topics in medicinal chemistry\| PubMed ID: 21320058	2011
Performance characteristics of a novel radioactive isotope detection and notification system designed for use in hospitals. Health physics\| PubMed ID: 21451311	2011
Antioxidant-chemoprevention diet ameliorates late effects of total-body irradiation and supplements radioprotection by MnSOD-plasmid liposome administration. Radiation research\| PubMed ID: 21466381	2011
Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators. International journal of radiation oncology, biology, physics\| PubMed ID: 21493014	2011
Quality assurance analysis of a large multicenter practice: does increased complexity of intensity-modulated radiotherapy lead to increased error frequency? International journal of radiation oncology, biology, physics\| PubMed ID: 21497453	2012
Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. In vivo (Athens, Greece)\| PubMed ID: 21576404	2011
The autophagy-inducing drug carbamazepine is a radiation protector and mitigator. International journal of radiation biology\| PubMed ID: 21728759	2011
The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death. ACS medicinal chemistry letters\| PubMed ID: 21826253	2011
GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. Radiation research\| PubMed ID: 21939290	2011
Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In vivo (Athens, Greece)\| PubMed ID: 22021675	2011
Role of the esophageal vagus neural pathway in ionizing irradiation-induced seizures in nitric oxide synthase-1 homologous recombinant negative NOS1-/- mice. In vivo (Athens, Greece)\| PubMed ID: 22021678	2011
Retrospective review of patients with locally advanced esophageal cancer treated at the University of Pittsburgh. American journal of clinical oncology\| PubMed ID: 22101387	2011
Repopulation of the irradiation damaged lung with bone marrow-derived cells. In vivo (Athens, Greece)\| PubMed ID: 22210711	2012
Dysregulated in vitro hematopoiesis, radiosensitivity, proliferation, and osteoblastogenesis with marrow from SAMP6 mice. Experimental hematology\| PubMed ID: 22326715	2012
Ionizing irradiation protection and mitigation of murine cells by carbamazepine is p53 and autophagy independent. In vivo (Athens, Greece)\| PubMed ID: 22523285	2012
Strategies for discovery of small molecule radiation protectors and radiation mitigators. Frontiers in oncology\| PubMed ID: 22655254	2011
The zebrafish--Danio rerio--is a useful model for measuring the effects of small-molecule mitigators of late effects of ionizing irradiation. In vivo (Athens, Greece)\| PubMed ID: 23160669	2012
Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice. In vivo (Athens, Greece)\| PubMed ID: 23606683	2013
Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & biomolecular chemistry\| PubMed ID: 23715589	2013
Increased longevity of hematopoiesis in continuous marrow cultures and radiation resistance of marrow stromal and hematopoietic progenitor cells from caspase-1 homozygous recombinant-negativ... In vivo (Athens, Greece)\| PubMed ID: 23812211	2013
Conditional radioresistance of Tet-inducible manganese superoxide dismutase bone marrow stromal cell lines. Radiation research\| PubMed ID: 23862693	2013
Radiation therapy induces the DNA damage response in peripheral blood. Oncotarget\| PubMed ID: 23900392	2013
Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Experimental hematology\| PubMed ID: 23933481	2013
Radioresistance of bone marrow stromal and hematopoietic progenitor cell lines derived from Nrf2-/- homozygous deletion recombinant-negative mice. In vivo (Athens, Greece)\| PubMed ID: 23988890	2013
Dosimetric definitions of total lung volumes in calculating parameters predictive for radiation-induced pneumonitis. American journal of clinical oncology\| PubMed ID: 24064747	2015
Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350). Radiation research\| PubMed ID: 24125487	2013
Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice. Radiation research\| PubMed ID: 24397476	2014
Improved survival of mice after total body irradiation with 10 MV photon, 2400 MU/min SRS beam. In vivo (Athens, Greece)\| PubMed ID: 24425830	2014
Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors. Frontiers in oncology\| PubMed ID: 24596683	2014
Differences in irradiated lung gene transcription between fibrosis-prone C57BL/6NHsd and fibrosis-resistant C3H/HeNHsd mice. In vivo (Athens, Greece)\| PubMed ID: 24632969	2014
Effects of mouse genotype on bone wound healing and irradiation-induced delay of healing. In vivo (Athens, Greece)\| PubMed ID: 24632972	2014
Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2(-/-) (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039. Radiation research\| PubMed ID: 24932534	2014
Improved longevity of hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Toll-like receptor-4 deletion recombinant-negative mice. In vivo (Athens, Greece)\| PubMed ID: 24982208	2014
Increased hematopoiesis in long-term bone marrow cultures and reduced irradiation-induced pulmonary fibrosis in Von Willebrand factor homologous deletion recombinant mice. In vivo (Athens, Greece)\| PubMed ID: 24982209	2014
Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. In vivo (Athens, Greece)\| PubMed ID: 24982210	2014
Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. In vivo (Athens, Greece)\| PubMed ID: 25189880	2014
Organ-specific responses of total body irradiated doxycycline-inducible manganese superoxide dismutase Tet/Tet mice. In vivo (Athens, Greece)\| PubMed ID: 25398796	2014
Quantitative evaluation of radiation oncologists' adaptability to lower reimbursing treatment programs. Practical radiation oncology\| PubMed ID: 25544552	2015
The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers\| PubMed ID: 26010604	2015
A Mobile Alert System for Preparing the Delivery of Radiation Mitigators. In vivo (Athens, Greece)\| PubMed ID: 26359406	2015
Radioresistant human lung adenocarcinoma cells that survived multiple fractions of ionizing radiation are sensitive to HSP90 inhibition. Oncotarget\| PubMed ID: 26517240	2015
Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants (Basel, Switzerland)\| PubMed ID: 26785339	2015
Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiation research\| PubMed ID: 26789701	2016
Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures. Oncotarget\| PubMed ID: 27637088	2016
Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In vivo (Athens, Greece)\| PubMed ID: 28064218	2017
Results of a Single Institution Experience with Dose-Escalated Chemoradiation for Locally Advanced Unresectable Non-Small Cell Lung Cancer. Frontiers in oncology\| PubMed ID: 28168163	2017
Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In vivo (Athens, Greece)\| PubMed ID: 28358695	2017
Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice. In vivo (Athens, Greece)\| PubMed ID: 28438857	2017
Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiation research\| PubMed ID: 29140165	2018
Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. Journal of pharmaceutical and biomedical analysis\| PubMed ID: 29245086	2018
Challenges in the Analysis of Outcomes for Surgical Compared to Radiotherapy Treatment of Prostate Cancer. In vivo (Athens, Greece)\| PubMed ID: 29275307	2018
Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca and Fancg Mice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiation research\| PubMed ID: 29584588	2018
Development of tensile strength methodology for murine skin wound healing. MethodsX\| PubMed ID: 30050753	2018
Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039). In vivo (Athens, Greece)\| PubMed ID: 30150422	2018
Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. ACS chemical biology\| PubMed ID: 30184433	2018
Malignant Transformation of Fanconi Anemia Complementation Group D2-deficient ( ) Hematopoietic Progenitor Cells by a Single HPV16 Oncogene. In vivo (Athens, Greece)\| PubMed ID: 30804107	2019
Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow C... Stem cells (Dayton, Ohio)\| PubMed ID: 30861238	2019
Amelioration of Amyotrophic Lateral Sclerosis in SOD1 Mice by M Microglia from Transplanted Marrow. In vivo (Athens, Greece)\| PubMed ID: 31028184	2019
Understanding the mechanism of radiation induced fibrosis and therapy options. Pharmacology & therapeutics\| PubMed ID: 31419518	2019
Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039. In vivo (Athens, Greece)\| PubMed ID: 31882460	2020
Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation. In vivo (Athens, Greece)\| PubMed ID: 31882461	2020
RE: Valstar et al., "The tubarial salivary glands: A potential new organ at risk for radiotherapy". Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology\| PubMed ID: 33310002	2021
Allogeneic adipose-derived stem cells mitigate acute radiation syndrome by the rescue of damaged bone marrow cells from apoptosis. Stem cells translational medicine\| PubMed ID: 33724714	2021
Silica Induced Lung Fibrosis Is Associated With Senescence, Fgr, and Recruitment of Bone Marrow Monocyte/Macrophages. In vivo (Athens, Greece)\| PubMed ID: 34697137	2021
Ionizing irradiation-induced Fgr in senescent cells mediates fibrosis. Cell death discovery\| PubMed ID: 34772919	2021