Philip R. LeDuc

Department of Mechanical Engineering, Carnegie Mellon University

Affiliated withCarnegie Mellon University Carnegie Mellon University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Integrated lithographic membranes and surface adhesion chemistry for three-dimensional cellular stimulation. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 15595783	2004
Evaluating spatial constraints in cellular assembly processes using a monte carlo approach. Cell biochemistry and biophysics\| PubMed ID: 16757820	2006
Understanding actin organization in cell structure through lattice based Monte Carlo simulations. Mechanics & chemistry of biosystems : MCB\| PubMed ID: 16783938	2004
Micropatterning polyvinyl alcohol as a biomimetic material through soft lithography with cell culture. Molecular bioSystems\| PubMed ID: 16880948	2006
Three-dimensional molecular phase separation and flow patterns with novel multilevel fluidics. Molecular & cellular biomechanics : MCB\| PubMed ID: 16903258	2006
Force-controlled inorganic crystallization lithography. Journal of the American Chemical Society\| PubMed ID: 16967953	2006
Pressure-driven spatiotemporal control of the laminar flow interface in a microfluidic network. Lab on a chip\| PubMed ID: 17476388	2007
Chemically encapsulated structural elements for probing the mechanical responses of biologically inspired systems. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17585787	2007
Creating ordered small-scale biologically-based rods through force-controlled stamping. Journal of the American Chemical Society\| PubMed ID: 17636910	2007
Computational models of molecular self-organization in cellular environments. Cell biochemistry and biophysics\| PubMed ID: 17703065	2007
Artificial cells: building bioinspired systems using small-scale biology. Trends in biotechnology\| PubMed ID: 18037179	2008
Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots. Nano letters\| PubMed ID: 18386936	2008
Towards an in vivo biologically inspired nanofactory. Nature nanotechnology\| PubMed ID: 18654192	2007
Stochastic off-lattice modeling of molecular self-assembly in crowded environments by Green's function reaction dynamics. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 18851069	2008
Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow. Methods (San Diego, Calif.)\| PubMed ID: 19015032	2009
Probing cell structure by controlling the mechanical environment with cell-substrate interactions. Journal of biomechanics\| PubMed ID: 19064266	2009
Understanding sensory nerve mechanotransduction through localized elastomeric matrix control. PloS one\| PubMed ID: 19173000	2009
Probing cellular dynamics with a chemical signal generator. PloS one\| PubMed ID: 19287482	2009
Composite polymer systems with control of local substrate elasticity and their effect on cytoskeletal and morphological characteristics of adherent cells. Biomaterials\| PubMed ID: 19299009	2009
Spatiotemporal control of apical and basal living subcellular chemical environments through vertical phase separation. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19548276	2009
Dynamics of individual polymers using microfluidic based microcurvilinear flow. Lab on a chip\| PubMed ID: 19636465	2009
Modulation of fluidic resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface. Lab on a chip\| PubMed ID: 19680585	2009
Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium. Lab on a chip\| PubMed ID: 19865741	2009
Parameter effects on binding chemistry in crowded media using a two-dimensional stochastic off-lattice model. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 19905353	2009
Probing cell structure responses through a shear and stretching mechanical stimulation technique. Cell biochemistry and biophysics\| PubMed ID: 20033625	2010
Three-dimensional chemical profile manipulation using two-dimensional autonomous microfluidic control. Journal of the American Chemical Society\| PubMed ID: 20063880	2010
Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20080785	2009
Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology. Nature protocols\| PubMed ID: 20360766	2010
Localized bimodal response of neurite extensions and structural proteins in dorsal-root ganglion neurons with controlled polydimethylsiloxane substrate stiffness. Journal of biomechanics\| PubMed ID: 21208617	2011
Response of an actin filament network model under cyclic stretching through a coarse grained Monte Carlo approach. Journal of theoretical biology\| PubMed ID: 21241710	2011
Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue. PloS one\| PubMed ID: 21305055	2011
Fabrication of circular microfluidic channels by combining mechanical micromilling and soft lithography. Lab on a chip\| PubMed ID: 21399830	2011
Microbial electricity generation via microfluidic flow control. Biotechnology and bioengineering\| PubMed ID: 21495007	2011
Dynamic control of 3D chemical profiles with a single 2D microfluidic platform. Lab on a chip\| PubMed ID: 21528131	2011
How do control-based approaches enter into biology? Annual review of biomedical engineering\| PubMed ID: 21599491	2011
Bioinspirations: cell-inspired small-scale systems for enabling studies in experimental biomechanics. Integrative and comparative biology\| PubMed ID: 21705801	2011
Investigating circular dorsal ruffles through varying substrate stiffness and mathematical modeling. Biophysical journal\| PubMed ID: 22067149	2011
Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments. PloS one\| PubMed ID: 22272286	2012
Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome: The Role of Loading History. Tissue engineering. Part A\| PubMed ID: 22280442	2012
Unified regression model of binding equilibria in crowded environments. Scientific reports\| PubMed ID: 22355615	2011
Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts. Scientific reports\| PubMed ID: 22355663	2011
Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling. Lab on a chip\| PubMed ID: 22374375	2012
Cells gain traction in 3D. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22778421	2012
Calcium signaling is gated by a mechanical threshold in three-dimensional environments. Scientific reports\| PubMed ID: 22870383	2012
Frontiers of optofluidics in synthetic biology. Lab on a chip\| PubMed ID: 22895798	2012
Biological colloid engineering: Self-assembly of dipolar ferromagnetic chains in a functionalized biogenic ferrofluid. Applied physics letters\| PubMed ID: 22952408	2012
Controlling magnetotactic bacteria through an integrated nanofabricated metallic island and optical microscope approach. Scientific reports\| PubMed ID: 24553101	2014
Mechanochemical actuators of embryonic epithelial contractility. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25246549	2014
Sudden motility reversal indicates sensing of magnetic field gradients in Magnetospirillum magneticum AMB-1 strain. The ISME journal\| PubMed ID: 25478682	2015
Beyond disease, how biomedical engineering can improve global health. Science translational medicine\| PubMed ID: 25504880	2014
Cellular force signal integration through vector logic gates. Journal of biomechanics\| PubMed ID: 25614090	2015
Structurally governed cell mechanotransduction through multiscale modeling. Scientific reports\| PubMed ID: 25722249	2015
Controlled surface topography regulates collective 3D migration by epithelial-mesenchymal composite embryonic tissues. Biomaterials\| PubMed ID: 25933063	2015
3D bio-etching of a complex composite-like embryonic tissue. Lab on a chip\| PubMed ID: 26138309	2015
The role of mechanics in biological and bio-inspired systems. Nature communications\| PubMed ID: 26145480	2015
Geometric effects in microfluidics on heterogeneous cell stress using an Eulerian-Lagrangian approach. Lab on a chip\| PubMed ID: 26753780	2016
Material Gradients in Stretchable Substrates toward Integrated Electronic Functionality. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 26989814	2016
2D and 3D Mechanobiology in Human and Nonhuman Systems. ACS applied materials & interfaces\| PubMed ID: 27214883	2016
Biomimetic scaffolds with three-dimensional undulated microtopographies. Biomaterials\| PubMed ID: 28325683	2017
How can we predict cellular mechanosensation?: Comment on "Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell resp... Physics of life reviews\| PubMed ID: 28890169	2017
Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28900011	2017
Mimicking Embedded Vasculature Structure for 3D Cancer on a Chip Approaches through Micromilling. Scientific reports\| PubMed ID: 29196753	2017
High-throughput mechanotransduction in Drosophila embryos with mesofluidics. Lab on a chip\| PubMed ID: 30778467	2019
Author Correction: Mimicking Embedded Vasculature Structure for 3D Cancer on a Chip Approaches through Micromilling. Scientific reports\| PubMed ID: 30918272	2019
Tumor-on-a-chip for integrating a 3D tumor microenvironment: chemical and mechanical factors. Lab on a chip\| PubMed ID: 32025687	2020
Polycarbonate Heat Molding for Soft Lithography. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 32227442	2020
Chemotactic Responses of Jurkat Cells in Microfluidic Flow-Free Gradient Chambers. Micromachines\| PubMed ID: 32260431	2020
Decidual Vasculopathy Identification in Whole Slide Images Using Multiresolution Hierarchical Convolutional Neural Networks. The American journal of pathology\| PubMed ID: 32679230	2020
3D In Vitro Neuron on a Chip for Probing Calcium Mechanostimulation. Advanced biosystems\| PubMed ID: 32875741	2020
Toward Vasculature in Skeletal Muscle-on-a-Chip through Thermo-Responsive Sacrificial Templates. Micromachines\| PubMed ID: 33007890	2020
Probing coordinated co-culture cancer related motility through differential micro-compartmentalized elastic substrates. Scientific reports\| PubMed ID: 33116169	2020
A biosensing soft robot: Autonomous parsing of chemical signals through integrated organic and inorganic interfaces. Science robotics\| PubMed ID: 33137770	2019
Hierarchical Machine Learning for High-Fidelity 3D Printed Biopolymers. ACS biomaterials science & engineering\| PubMed ID: 33320614	2020
3D Collagen Vascular Tumor-on-a-Chip Mimetics for Dynamic Combinatorial Drug Screening. Molecular cancer therapeutics\| PubMed ID: 33785649	2021
Cell alignment modulated by surface nano-topography - Roles of cell-matrix and cell-cell interactions. Acta biomaterialia\| PubMed ID: 35124266	2022
Toward sustainable desalination using food waste: capacitive desalination with bread-derived electrodes. RSC advances\| PubMed ID: 35423429	2021
Microfluidics for understanding model organisms. Nature communications\| PubMed ID: 35680898	2022
Freeform 3D Ice Printing (3D-ICE) at the Micro Scale. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 35794454	2022
Inducing Vascular Grammars for Anomaly Classification in Brain Angiograms. Journal of engineering and science in medical diagnostics and therapy\| PubMed ID: 35833206	2022