John M. Leong

Department of Molecular Biology and Microbiology, Tufts University School of Medicine

Affiliated withTufts University School of Medicine Tufts University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2022

Other Publications

Article	Year
Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment. PLoS pathogens\| PubMed ID: 26313746	2015
Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli. Frontiers in microbiology\| PubMed ID: 22073041	2011
Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host. Frontiers in microbiology\| PubMed ID: 22102844	2011
Allele- and tir-independent functions of intimin in diverse animal infection models. Frontiers in microbiology\| PubMed ID: 22347213	2012
Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli. The Journal of biological chemistry\| PubMed ID: 22544751	2012
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell\| PubMed ID: 22819539	2012
Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infection and immunity\| PubMed ID: 22966049	2012
A novel murine infection model for Shiga toxin-producing Escherichia coli. The Journal of clinical investigation\| PubMed ID: 23041631	2012
Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infectious disease clinics of North America\| PubMed ID: 24011834	2013
The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cellular microbiology\| PubMed ID: 24780054	2014
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24828532	2014
Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection. Infection and immunity\| PubMed ID: 24842928	2014
Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation. Infection and immunity\| PubMed ID: 24958711	2014
Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete. PLoS pathogens\| PubMed ID: 25079227	2014
Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue. Infection and immunity\| PubMed ID: 25312954	2015
Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization. Cellular microbiology\| PubMed ID: 25486989	2015
The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25512603	2015
Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity. Cellular microbiology\| PubMed ID: 25604835	2015
Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete. Cellular microbiology\| PubMed ID: 25864455	2015
Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection. Cellular microbiology\| PubMed ID: 26247174	2016
Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation. Infection and immunity\| PubMed ID: 26483408	2016
A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response. Toxins\| PubMed ID: 27598200	2016
Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic Infection Using Food-Borne Inoculation. Frontiers in cellular and infection microbiology\| PubMed ID: 27857935	2016
Cytosolic Phospholipase Aα Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection. Infection and immunity\| PubMed ID: 28808157	2017
Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival. Cellular microbiology\| PubMed ID: 28873507	2017
Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29032536	2018
Correction for Jandhyala et al., "Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin... Infection and immunity\| PubMed ID: 29259142	2018
Pearls collections: What we can learn about infectious disease and cancer. PLoS pathogens\| PubMed ID: 29596508	2018
Plasticity in early immune evasion strategies of a bacterial pathogen. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29610317	2018
Nasopharyngeal Exposure to Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138 Cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29661828	2018
Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29675452	2018
Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection. mSphere\| PubMed ID: 29976647	2018
A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor. Cellular microbiology\| PubMed ID: 31709673	2020
Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 31776202	2020
Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production. Journal of leukocyte biology\| PubMed ID: 32017200	2020
Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C. PLoS pathogens\| PubMed ID: 32413091	2020
Macrophage LC3-associated phagocytosis is an immune defense against that diminishes with host aging. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33376222	2020
Citrobacter rodentium Lysogenized with a Shiga Toxin-Producing Phage: A Murine Model for Shiga Toxin-Producing E. coli Infection. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33704765	2021
A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age. Infection and immunity\| PubMed ID: 34031128	2021
Host-informed therapies for the treatment of pneumococcal pneumonia. Trends in molecular medicine\| PubMed ID: 34376327	2021
Scalable Reporter Assays to Analyze the Regulation of Expression in Shiga Toxin-Producing Enteropathogens. Toxins\| PubMed ID: 34437405	2021
Editorial overview of Pearls Microbiome Series: E pluribus unum. PLoS pathogens\| PubMed ID: 34464427	2021
Citrobacter rodentium(ϕStx2dact), a murine infection model for enterohemorrhagic Escherichia coli. Current opinion in microbiology\| PubMed ID: 34929548	2022
The Yin and Yang of Pneumolysin During Pneumococcal Infection. Frontiers in immunology\| PubMed ID: 35529870	2022
VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force. PLoS pathogens\| PubMed ID: 35605029	2022
Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917. PLoS pathogens\| PubMed ID: 36107831	2022