Norbert Frey

Internal Medicine III, University Hospital Heidelberg, Partner Site Heidelberg/Mannheim

Affiliated withUniversity Hospital Heidelberg, Partner Site Heidelberg/Mannheim University Hospital Heidelberg German Centre for Cardiovascular Research (DZHK), Partner site Heidelberg/Mannheim

Research Area

Medicine

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 1	2022
Publication title Cited by 1	2025

Other Publications

Article	Year
Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress. Nature medicine\| PubMed ID: 15543153	2004
Alterations of tension-dependent ATP utilization in a transgenic rat model of hypertrophic cardiomyopathy. The Journal of biological chemistry\| PubMed ID: 16882671	2006
Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. The Journal of clinical investigation\| PubMed ID: 18846255	2008
HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome research\| PubMed ID: 19064678	2009
Whole-genome analysis of gene expression associates the ubiquitin-proteasome system with the cardiomyopathy phenotype in disease-sensitized congenic mouse strains. Cardiovascular research\| PubMed ID: 22308238	2012
TREK-1 (K2.1) K channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control. Basic research in cardiology\| PubMed ID: 28005193	2017
Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure. Cardiovascular research\| PubMed ID: 30418544	2019
Catheter ablation of atrial fibrillation in women with heart failure with preserved ejection fraction. Frontiers in cardiovascular medicine\| PubMed ID: 39588067	2024
AAV-mediated TIMP-1 overexpression in aortic tissue reduces the severity of allograft vasculopathy in mice. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation\| PubMed ID: 32035727	2020
AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of Marfan syndrome. Cardiovascular research\| PubMed ID: 33471064	2021
Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Basic research in cardiology\| PubMed ID: 33630168	2021
Improvement of renal function after transcatheter aortic valve replacement and its impact on survival. BMC nephrology\| PubMed ID: 33653283	2021
Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue. Molecular therapy. Methods & clinical development\| PubMed ID: 33768132	2021
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut\| PubMed ID: 33888516	2021
Impact of Anesthesia Strategy and Valve Type on Clinical Outcomes After Transcatheter Aortic Valve Replacement. Journal of the American College of Cardiology\| PubMed ID: 33926657	2021
AAV-mediated expression of NFAT decoy oligonucleotides protects from cardiac hypertrophy and heart failure. Basic research in cardiology\| PubMed ID: 34089101	2021
Safety and effectiveness of Phoenix atherectomy for endovascular treatment in calcified common femoral artery lesions. VASA. Zeitschrift fur Gefasskrankheiten\| PubMed ID: 34155913	2021
Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure. Life sciences\| PubMed ID: 34186046	2021
Basophils balance healing after myocardial infarction via IL-4/IL-13. The Journal of clinical investigation\| PubMed ID: 34196299	2021
Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival. ESC heart failure\| PubMed ID: 34213089	2021
High-sensitivity cardiac troponin T determines all-cause mortality in cancer patients: a single-centre cohort study. ESC heart failure\| PubMed ID: 34396713	2021
PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results. ESC heart failure\| PubMed ID: 34448541	2021
Atrial fibrillation before heart transplantation is a risk factor for post-transplant atrial fibrillation and mortality. ESC heart failure\| PubMed ID: 34453484	2021
Influence of receptor selectivity on benefits from SGLT2 inhibitors in patients with heart failure: a systematic review and head-to-head comparative efficacy network meta-analysis. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 34498169	2022
Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling. EMBO reports\| PubMed ID: 34605609	2021
Non-Vitamin K Antagonist Oral Anticoagulants in Coronary Artery Disease. Hamostaseologie\| PubMed ID: 34662918	2022
SH3-Binding Glutamic Acid Rich-Deficiency Augments Apoptosis in Neonatal Rat Cardiomyocytes. International journal of molecular sciences\| PubMed ID: 34681711	2021
Electrical Ventricular Remodeling in Dilated Cardiomyopathy. Cells\| PubMed ID: 34685747	2021
Controlling my genome with my smartphone: first clinical experiences of the PROMISE system. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 34694434	2022
Diagnostic Work-Up of Cardiac Amyloidosis Using Cardiovascular Imaging: Current Standards and Practical Algorithms. Vascular health and risk management\| PubMed ID: 34720583	2021
Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis: a systematic review and meta-analysis. BMJ open\| PubMed ID: 34873012	2021
Cancer-A Major Cardiac Comorbidity With Implications on Cardiovascular Metabolism. Frontiers in physiology\| PubMed ID: 34899373	2021
HFA-PEFF score: prognosis in patients with preserved ejection fraction after transcatheter aortic valve implantation. ESC heart failure\| PubMed ID: 35092186	2022
One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair. ESC heart failure\| PubMed ID: 35170230	2022
MicroRNAs Regulate TASK-1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation. Journal of the American Heart Association\| PubMed ID: 35301863	2022
The predictive value of self-compassion for psychological adjustment in left ventricular assist device patients: an observational study. ESC heart failure\| PubMed ID: 35439842	2022
SRF: a seriously responsible factor in cardiac development and disease. Journal of biomedical science\| PubMed ID: 35681202	2022
VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. International journal of molecular sciences\| PubMed ID: 35806332	2022
Case report of an S-ICD implantation for secondary prevention in a patient with complex congenital heart disease, dextrocardia, and situs solitus. European heart journal. Case reports\| PubMed ID: 35821967	2022
Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension. Human gene therapy\| PubMed ID: 35850528	2022
Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise. Circulation\| PubMed ID: 35862076	2022
Impact of moderate or severe left ventricular outflow tract calcification on clinical outcomes of patients with severe aortic stenosis undergoing transcatheter aortic valve implantation with... EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology\| PubMed ID: 35942626	2022
Large Mobile Left Ventricular Thrombi Formation in a 32-Year-Old Despite Direct Oral Anticoagulation With Dabigatran. JACC. Case reports\| PubMed ID: 36062055	2022
Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction. Circulation. Heart failure\| PubMed ID: 36126143	2022
Long-Term Patency of Venous Conduits Targeting the Right Coronary Artery System-Single Is Superior to Sequential bypass Grafting. Journal of cardiovascular development and disease\| PubMed ID: 36135430	2022
Haemodynamic Effects of Sacubitril/Valsartan Initiation in Outpatients with Chronic Heart Failure. American journal of cardiovascular drugs : drugs, devices, and other interventions\| PubMed ID: 36136241	2022
The Obesity Paradox in Heart Failure: Is It Still Valid in Light of New Therapies? Cardiology\| PubMed ID: 36195066	2022
Genotype Complements the Phenotype: Identification of the Pathogenicity of an LMNA Splice Variant by Nanopore Long-Read Sequencing in a Large DCM Family. International journal of molecular sciences\| PubMed ID: 36293084	2022
Blockade of Wnt Secretion Attenuates Myocardial Ischemia-Reperfusion Injury by Modulating the Inflammatory Response. International journal of molecular sciences\| PubMed ID: 36293109	2022
Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP binding. Naunyn-Schmiedeberg's archives of pharmacology\| PubMed ID: 36445385	2023
Initial experience with transcatheter tricuspid valve repair in patients with cardiac amyloidosis. ESC heart failure\| PubMed ID: 36514259	2023
Cardiac Troponins for the Clinical Management of Patients with Claudication and without Cardiac Symptoms. Journal of clinical medicine\| PubMed ID: 36555902	2022
Exploring biomarkers in routine diagnostics for the risk stratification of older patients in the Chest Pain Unit: a prospective cohort study. BMJ open\| PubMed ID: 36572487	2022
Prognostic relevance of gradual weight changes on long-term mortality in chronic heart failure. Nutrition, metabolism, and cardiovascular diseases : NMCD\| PubMed ID: 36604261	2023
Coronary Computed Tomography vs. Cardiac Magnetic Resonance Imaging in the Evaluation of Coronary Artery Disease. Diagnostics (Basel, Switzerland)\| PubMed ID: 36611417	2022
Dynamic Morphology of the Ascending Aorta and Its Implications for Proximal Landing in Thoracic Endovascular Aortic Repair. Journal of clinical medicine\| PubMed ID: 36614871	2022
Left atrial appendage closure in end-stage renal disease and hemodialysis: Data from a German multicenter registry. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions\| PubMed ID: 36682074	2023
Influence of Tricuspid Regurgitation After Heart Transplantation: A Single-center Experience. Transplantation direct\| PubMed ID: 36845859	2023
The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 36884078	2023
Adapted clustering method for generic analysis of histological fibrosis staining as an open source tool. Scientific reports\| PubMed ID: 36928369	2023
Mid-regional pro-adrenomedullin and lactate levels for risk stratification in patients with out-of-hospital cardiac arrest. European heart journal. Acute cardiovascular care\| PubMed ID: 36943296	2023
A distributable German clinical corpus containing cardiovascular clinical routine doctor's letters. Scientific data\| PubMed ID: 37059736	2023
Safety, Effectiveness, and Midterm Results of Endovascular Treatment for the Common Femoral Artery: A Two Centre Atherectomy Trial. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery\| PubMed ID: 37087070	2023
Exploring the Involvement of Gut Microbiota in Cancer Therapy-Induced Cardiotoxicity. International journal of molecular sciences\| PubMed ID: 37108423	2023
Aspirin use and bleeding events during thrombocytopenia after autologous stem-cell transplantation for multiple myeloma. Frontiers in oncology\| PubMed ID: 37182183	2023
Translational control of Ybx1 expression regulates cardiac function in response to pressure overload in vivo. Basic research in cardiology\| PubMed ID: 37378715	2023
Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction. Frontiers in immunology\| PubMed ID: 37426649	2023
Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy. Open heart\| PubMed ID: 37463823	2023
Long-Term Trajectories of Biomarkers, Functional, and Echocardiographic Parameters in Patients with Chronic Heart Failure from Dilated or Ischaemic Cardiomyopathy. Cardiology\| PubMed ID: 37517385	2023
Glycaemic control and insulin therapy are significant confounders of the obesity paradox in patients with heart failure and diabetes mellitus. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 37608126	2024
Modification of the GRACE Risk Score for Risk Prediction in Patients With Acute Coronary Syndromes. JAMA cardiology\| PubMed ID: 37647046	2023
Pericoronary adipose tissue attenuation is associated with non-calcified plaque burden in patients with chronic coronary syndromes. Journal of cardiovascular computed tomography\| PubMed ID: 37659885	2023
Activation of neurokinin-III receptors modulates human atrial TASK-1 currents. Journal of molecular and cellular cardiology\| PubMed ID: 37793594	2023
Complications in patients with cardiogenic shock on veno-arterial extracorporeal membrane oxygenation therapy: distribution and relevance. Results from an international, multicentre cohort s... European heart journal. Acute cardiovascular care\| PubMed ID: 37875127	2024
Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability. The ISME journal\| PubMed ID: 37891427	2023
Recurrent ventricular tachycardia originating from the "left ventricular summit" effectively eliminated by stereotactic irradiation - A case report. HeartRhythm case reports\| PubMed ID: 38023678	2023
GPD1L-A306del modifies sodium current in a family carrying the dysfunctional SCN5A-G1661R mutation associated with Brugada syndrome. Pflugers Archiv : European journal of physiology\| PubMed ID: 38036776	2024
Multi-parametric non-contrast cardiac magnetic resonance for the differentiation between cardiac amyloidosis and hypertrophic cardiomyopathy. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 38095711	2024
Insulin resistance in Takotsubo syndrome. ESC heart failure\| PubMed ID: 38123355	2024
Acute antiarrhythmic effects of SGLT2 inhibitors-dapagliflozin lowers the excitability of atrial cardiomyocytes. Basic research in cardiology\| PubMed ID: 38170280	2024
Regnase-1 overexpression as a therapeutic approach of Marfan syndrome. Molecular therapy. Methods & clinical development\| PubMed ID: 38178915	2024
Acute changes in cardiac dimensions, function, and longitudinal mechanics in healthy individuals with and without high-altitude induced pulmonary hypertension at 4559 m. Echocardiography (Mount Kisco, N.Y.)\| PubMed ID: 38400544	2024
Evaluation of all-cause mortality and cardiovascular safety in patients receiving chimeric antigen receptor T cell therapy: a prospective cohort study. EClinicalMedicine\| PubMed ID: 38544797	2024
Reverse cardio-oncology: is heart failure-mediated gut dysbiosis the mechanistic driver of colorectal cancer progression? Cardiovascular research\| PubMed ID: 38547372	2024
Long-term safety and effectiveness of the Fantom bioresorbable coronary artery scaffold: final results of the FANTOM II trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology\| PubMed ID: 38562069	2024
Transcatheter or Surgical Treatment of Aortic-Valve Stenosis. The New England journal of medicine\| PubMed ID: 38588025	2024
Design, Rationale and Initial Findings From HERA-FIB on 10 222 Patients With Atrial Fibrillation Presenting to an Emergency Department Over An 11-Year Period. Journal of the American Heart Association\| PubMed ID: 38639359	2024
Prognostic Value of Standard Heart Failure Medication in Patients with Cardiac Transthyretin Amyloidosis. Journal of clinical medicine\| PubMed ID: 38673530	2024
A porcine large animal model of radiofrequency ablation-induced left bundle branch block. Frontiers in physiology\| PubMed ID: 38706948	2024
Accelerated high sensitivity troponin diagnostics: ready for an even faster pace? European heart journal\| PubMed ID: 38860689	2024
Editorial: Proteostasis in cardiac health and disease. Frontiers in molecular biosciences\| PubMed ID: 38882607	2024
Electrophysiological Effects of the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitor Dapagliflozin on Human Cardiac Potassium Channels. International journal of molecular sciences\| PubMed ID: 38891889	2024
Cardiac stereotactic body radiotherapy to treat malignant ventricular arrhythmias directly affects the cardiomyocyte electrophysiology. Heart rhythm\| PubMed ID: 38936449	2025
Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial. ESC heart failure\| PubMed ID: 39010317	2024
Response to therapy with tafamidis 61 mg in patients with cardiac transthyretin amyloidosis: real-world experience since approval. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis\| PubMed ID: 39018203	2024
Virtual cardiovascular magnetic resonance training proves feasible and effective: survey data from international participants of the CMR Academy Berlin, Germany. European heart journal. Imaging methods and practice\| PubMed ID: 39044796	2023
CITED4 gene therapy protects against maladaptive cardiac remodeling after ischemia/reperfusion injury in mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 39066479	2024
Effects of high- versus low-intensity lipid-lowering treatment in patients undergoing serial coronary computed tomography angiography: results of the multi-center LOCATE study. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 39080016	2024
Community-based analysis of stroke prevention and effect of public interventions in atrial fibrillation: results from the ARENA project. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 39115608	2025
Favorable safety profile of NOAC therapy in patients after tricuspid transcatheter edge-to-edge repair. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 39158599	2024
Calcineurin signaling promotes takotsubo syndrome. Nature cardiovascular research\| PubMed ID: 39195924	2023
Transient Inhibition of Translation Improves Cardiac Function After Ischemia/Reperfusion by Attenuating the Inflammatory Response. Circulation\| PubMed ID: 39206545	2024
Natriuretic peptides and cardiac hs-troponins as surrogates of cardiomyocyte stress: clinical value in hypertrophic cardiomyopathy? European heart journal\| PubMed ID: 39217443	2024
EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 39256221	2024
Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging: A Systematic Review and Meta-Analysis. JAMA\| PubMed ID: 39298146	2024
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation. Signal transduction and targeted therapy\| PubMed ID: 39307902	2024
Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases. Frontiers in cardiovascular medicine\| PubMed ID: 39314768	2024
2 Rare Syndromes in 1 Patient: Determining the Cause of Sudden Cardiac Arrest. JACC. Case reports\| PubMed ID: 39359994	2024
A Remote Patient Monitoring System With Feedback Mechanisms Using a Smartwatch: Concept, Implementation, and Evaluation Based on the activeDCM Randomized Controlled Trial. JMIR mHealth and uHealth\| PubMed ID: 39365164	2024
Cardiovascular Events After Chimeric Antigen Receptor T-Cell Therapy for Advanced Hematologic Malignant Neoplasms: A Meta-Analysis. JAMA network open\| PubMed ID: 39374017	2024
Endothelial activation and stress index (EASIX) in coronary artery disease: a simplified measure as a promising biomarker. Clinical research in cardiology : official journal of the German Cardiac Society\| PubMed ID: 39535591	2024
Cardiac arrhythmias during and after thoracic irradiation for malignancies. Cardio-oncology (London, England)\| PubMed ID: 39543778	2024
Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British journal of pharmacology\| PubMed ID: 39543799	2024
Absence of cardiac impairment in patients after severe acute respiratory syndrome coronavirus type 2 infection: A long-term follow-up study. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 39549839	2024
Rationale and Design of the HERZCHECK trial: Detection of Early Heart Failure Using Telemedicine and CMR in Structurally Weak Regions (NCT05122793). Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance\| PubMed ID: 39824461	2025
Composite cardiac computed tomography angiography score for improved risk assessment in chronic coronary syndromes. Scientific reports\| PubMed ID: 39856114	2025
A novel uORF regulates folliculin to promote cell growth and lysosomal biogenesis during cardiac stress. Scientific reports\| PubMed ID: 39865126	2025
Clinical impact of inappropriate DOAC dosing in atrial fibrillation: Insights from a real-world registry. International journal of cardiology. Heart & vasculature\| PubMed ID: 39867851	2025