application-deep-learning-based-medical-image-segmentation-via

Application of Deep Learning-Based Medical Image Segmentation <em>via</em> Orbital Computed Tomography

Recently, deep learning-based segmentation models have been widely applied in the ophthalmic field. This study presents the complete process of ...

The Catholic University of Korea

St. Vincent’s Hospital

The Catholic University of korea

To evaluate the effectiveness of cyclosporine 0.05% for dry eye after cataract surgery.

The effect of topical cyclosporine 0.05% on dry eye after cataract surgery.

To compare the effects of the surgical insult of cataract surgery on corneal inflammatory infiltration, neovascularization (NV) and lymphangiogenesis (LY) between the dry eye and non-dry eye in murine cataract surgery models.

Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model.

To evaluate whether trapping vascular endothelial growth factor A (VEGF-A) would suppress angiogenesis and inflammation in dry eye corneas in a murine corneal suture model.

Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization.

To identify and compare specific protein levels between overacting inferior oblique (IO) muscles in superior oblique (SO) palsy patients and normal IO muscles.

Expression of MyoD, insulin like growth factor binding protein, thioredoxin and p27 in secondarily overacting inferior oblique muscles with superior oblique palsy.

To analyze the surgical and sensory outcomes of intermittent exotropia according to refractive errors and the factors associated with surgical success.

Surgical and sensory outcomes in patients with intermittent exotropia according to preoperative refractive error.

This study explored the anti-inflammatory effects of a glucagon-like peptide-1 receptor agonist (GLP-1RA), known as lixisenatide, on the eyes of early type 2 diabetic mice. Diabetic (db/db) mice were divided into three groups: GLP-1RA [lixisenatide (LIX)], insulin (INS) with controlled hyperglycemia based on the glucose concentration of lixisenatide, and diabetic control (D-CON). Nondiabetic control mice (db/dm) were also characterized for comparison. After 8 weeks of treatment, mRNA levels of inflammatory markers, terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, immunohistochemical staining; Western blot of glial fibrillary acidic protein (GFAP) and thioredoxin-interacting protein; and retinal thickness were assessed in the central and peripheral neurosensory retina. LIX showed decreased immunohistochemical staining for both thioredoxin-interacting protein and GFAP in the central and peripheral neurosensory retina compared with D-CON and INS, and decreased expression of these proteins in the neurosensory retina and immunohistochemical staining in the optic nerve head for GFAP compared with D-CON. The inner nuclear layer in the peripheral retina in LIX was only thinner than those of D-CON and INS. In an early type 2 diabetic mouse model, lixisenatide treatment showed superior anti-inflammatory effects on the retina and optic nerve head independent of hyperglycemia. Thus, the neuroprotective effects of lixisenatide treatment in the peripheral inner nuclear layer should be evaluated in early type 2 diabetic retinopathy.

The Anti-Inflammatory Effects of Glucagon-Like Peptide Receptor Agonist Lixisenatide on the Retinal Nuclear and Nerve Fiber Layers in an Animal Model of Early Type 2 Diabetes.

Allopurinol is the first-line agent for patients with gout, including those with moderate-to-severe chronic kidney disease. However, increased thyroid-stimulating hormone (TSH) levels are observed in patients with long-term allopurinol treatment. This large-scale, nested case-control, retrospective observational study analysed the association between allopurinol use and increased TSH levels. A common data model based on an electronic medical record database of 19,200,973 patients from seven hospitals between January 1997 and September 2020 was used. Individuals aged > 19 years in South Korea with at least one record of a blood TSH test were included. Data of 59,307 cases with TSH levels > 4.5 mIU/L and 236,508 controls matched for sex, age (± 5), and cohort registration date (± 30 days) were analysed. An association between the risk of increased TSH and allopurinol use in participants from five hospitals was observed. A meta-analysis (I = 0) showed that the OR was 1.51 (95% confidence interval: 1.32-1.72) in both the fixed and random effects models. The allopurinol intake group demonstrated that increased TSH did not significantly affect free thyroxine and thyroxine levels. After the index date, some diseases were likely to occur in patients with subclinical hypothyroidism and hypothyroidism. Allopurinol administration may induce subclinical hypothyroidism.

Association between the use of allopurinol and risk of increased thyroid-stimulating hormone level.

A case of unsuspected trans-orbital-cranial penetrating injury by a wooden chopstick in a one-year-old infant.

Temporary severe oculomotor nerve palsy after reconstruction of orbital medial wall fracture: a case report of nonfamiliar complication.

To explore the possibility of using glucagon-like peptide-1 receptor agonist (GLP-1RA) as a new treatment for neuroinflammation, by analyzing retinal pathological changes in an optic nerve crush rat model.

Article	Year
The effect of topical cyclosporine 0.05% on dry eye after cataract surgery. Korean journal of ophthalmology : KJO\| PubMed ID: 23730108	2013
Comparison of postoperative corneal changes between dry eye and non-dry eye in a murine cataract surgery model. International journal of ophthalmology\| PubMed ID: 26949638	2016
Effect of trapping vascular endothelial growth factor-A in a murine model of dry eye with inflammatory neovascularization. International journal of ophthalmology\| PubMed ID: 27990354	2016
Expression of MyoD, insulin like growth factor binding protein, thioredoxin and p27 in secondarily overacting inferior oblique muscles with superior oblique palsy. BMC ophthalmology\| PubMed ID: 29843669	2018
Surgical and sensory outcomes in patients with intermittent exotropia according to preoperative refractive error. Eye (London, England)\| PubMed ID: 30932034	2019
The Anti-Inflammatory Effects of Glucagon-Like Peptide Receptor Agonist Lixisenatide on the Retinal Nuclear and Nerve Fiber Layers in an Animal Model of Early Type 2 Diabetes. The American journal of pathology\| PubMed ID: 32354571	2020
Association between the use of allopurinol and risk of increased thyroid-stimulating hormone level. Scientific reports\| PubMed ID: 34645831	2021
A case of unsuspected trans-orbital-cranial penetrating injury by a wooden chopstick in a one-year-old infant. International journal of ophthalmology\| PubMed ID: 35310048	2022
Temporary severe oculomotor nerve palsy after reconstruction of orbital medial wall fracture: a case report of nonfamiliar complication. International journal of ophthalmology\| PubMed ID: 35814906	2022
Anti-inflammatory effect of glucagon-like Peptide-1 receptor agonist on the neurosensory retina in an acute optic nerve injury rat model. European journal of pharmacology\| PubMed ID: 36103932	2022

Yeon Woong Chung

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