Adam D. Bachstetter

Spinal Cord & Brain Injury Research Center, University of Kentucky

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 9	2022

Other Publications

Article	Year
CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of neuroinflammation\| PubMed ID: 21266082	2011
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). Journal of neuroinflammation\| PubMed ID: 21733175	2011
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα. Molecular neurodegeneration\| PubMed ID: 22185458	2011
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS. Aging and disease\| PubMed ID: 22720195	2010
Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease... The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22836255	2012
Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23152597	2012
Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models. PloS one\| PubMed ID: 23457629	2013
The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23554495	2013
Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease. Alzheimer's research & therapy\| PubMed ID: 23705774	2013
Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction. PloS one\| PubMed ID: 23840427	2013
Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain. Journal of neuroinflammation\| PubMed ID: 24314267	2013
Diffuse brain injury induces acute post-traumatic sleep. PloS one\| PubMed ID: 24416145	2014
Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 24789302	2014
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Frontiers in genetics\| PubMed ID: 24795750	2014
Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults. Journal of molecular neuroscience : MN\| PubMed ID: 25012593	2015
Generation and behavior characterization of CaMKIIβ knockout mice. PloS one\| PubMed ID: 25127391	2014
The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism. Journal of neuroinflammation\| PubMed ID: 25297465	2014
Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic. Journal of neuroinflammation\| PubMed ID: 25886256	2015
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25904805	2015
Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta neuropathologica communications\| PubMed ID: 26001591	2015
Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury. Journal of neuroinflammation\| PubMed ID: 26329692	2015
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism\| PubMed ID: 26738751	2017
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses. PloS one\| PubMed ID: 26871438	2016
Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury. Journal of neurotrauma\| PubMed ID: 27142118	2017
Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge. Molecular pain\| PubMed ID: 27178244	2016
Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry\| PubMed ID: 27248001	2016
Rod-shaped microglia morphology is associated with aging in 2 human autopsy series. Neurobiology of aging\| PubMed ID: 28131016	2017
Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi. Brain pathology (Zurich, Switzerland)\| PubMed ID: 28281308	2018
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes. Journal of neuroinflammation\| PubMed ID: 28381303	2017
Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury. Journal of neuroinflammation\| PubMed ID: 29789012	2018
A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism. Journal of neurotrauma\| PubMed ID: 29808778	2018
Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism. Neural regeneration research\| PubMed ID: 30136679	2018
Simulation of P2X-mediated calcium signalling in microglia. The Journal of physiology\| PubMed ID: 30462840	2019
Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model. Neuroscience\| PubMed ID: 30529693	2019
A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats. Journal of neurotrauma\| PubMed ID: 30661454	2019
Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice. Alzheimer's & dementia (New York, N. Y.)\| PubMed ID: 30859123	2019
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia. GeroScience\| PubMed ID: 31104189	2019
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene. Journal of neuropathology and experimental neurology\| PubMed ID: 31748784	2020
The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review. Experimental neurology\| PubMed ID: 31930992	2020
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice. Journal of neuroinflammation\| PubMed ID: 32290848	2020
An active avoidance behavioral paradigm for use in a mild closed head model of traumatic brain injury in mice. Journal of neuroscience methods\| PubMed ID: 32592717	2020
Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury. PloS one\| PubMed ID: 32810143	2020
Pre-Clinical Common Data Elements for Traumatic Brain Injury Research: Progress and Use Cases. Journal of neurotrauma\| PubMed ID: 33297844	2021
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain. Neurobiology of aging\| PubMed ID: 33422891	2021
Space-occupying brain lesions, trauma-related tau astrogliopathy, and ARTAG: a report of two cases and a literature review. Acta neuropathologica communications\| PubMed ID: 33757579	2021
Inflammatory Regulation of CNS Barriers After Traumatic Brain Injury: A Tale Directed by Interleukin-1. Frontiers in immunology\| PubMed ID: 34093593	2021
Dysregulation of Systemic Immunity in Aging and Dementia. Frontiers in cellular neuroscience\| PubMed ID: 34239415	2021
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities. Nature reviews. Endocrinology\| PubMed ID: 34703027	2022
Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. Journal of cellular immunology\| PubMed ID: 35611116	2022