Ravindra Majeti

Division of Hematology, Stanford University School of Medicine

Affiliated withStanford University School of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 5	2023
Publication title Cited by 4	2023

Other Publications

Article	Year
The adhesion molecule esam1 is a novel hematopoietic stem cell marker. Stem cells (Dayton, Ohio)\| PubMed ID: 19074415	2009
CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis. Cell\| PubMed ID: 19632178	2009
CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell\| PubMed ID: 19632179	2009
Metastatic cancer stem cells: an opportunity for improving cancer treatment? Cell stem cell\| PubMed ID: 20569685	2010
Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells. Oncogene\| PubMed ID: 21076471	2011
Association of a leukemic stem cell gene expression signature with clinical outcomes in acute myeloid leukemia. JAMA\| PubMed ID: 21177505	2010
Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye. Cancer cell\| PubMed ID: 21251611	2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments. Blood\| PubMed ID: 21357764	2011
Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21383193	2011
Surprise! HSC are aberrant in chronic lymphocytic leukemia. Cancer cell\| PubMed ID: 21840478	2011
Treatment advances have not improved the early death rate in acute promyelocytic leukemia. Haematologica\| PubMed ID: 21993679	2012
Programmed cell removal: a new obstacle in the road to developing cancer. Nature reviews. Cancer\| PubMed ID: 22158022	2012
The CD47-SIRPÎ± pathway in cancer immune evasion and potential therapeutic implications. Current opinion in immunology\| PubMed ID: 22310103	2012
Clonal evolution of acute leukemia genomes. Oncogene\| PubMed ID: 22349821	2013
Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22451919	2012
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Science translational medicine\| PubMed ID: 22932223	2012
The cancer stem cell model: B cell acute lymphoblastic leukaemia breaks the mould. EMBO molecular medicine\| PubMed ID: 23229878	2013
Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia. International journal of hematology\| PubMed ID: 23949914	2013
Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24550281	2014
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms. PloS one\| PubMed ID: 24658090	2014
Interaction of TIF-90 and filamin A in the regulation of rRNA synthesis in leukemic cells. Blood\| PubMed ID: 24850755	2014
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma. Nature communications\| PubMed ID: 24887457	2014
Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia\| PubMed ID: 25005245	2014
Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition. Blood\| PubMed ID: 25398938	2015
Clonal evolution of pre-leukemic hematopoietic stem cells precedes human acute myeloid leukemia. Best practice & research. Clinical haematology\| PubMed ID: 25455271	2014
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia. Nature medicine\| PubMed ID: 25599133	2015
Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell\| PubMed ID: 25728669	2015
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25775523	2015
Reply to Fišer et al.: Myeloid reprogramming of Ph+ B-ALL: A potential therapeutic strategy. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26069209	2015
Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells. Seminars in hematology\| PubMed ID: 26111462	2015
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential. PloS one\| PubMed ID: 26390038	2015
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Cell stem cell\| PubMed ID: 26607380	2015
SIRPα-Antibody Fusion Proteins Selectively Bind and Eliminate Dual Antigen-Expressing Tumor Cells. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 27126995	2016
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Cancer discovery\| PubMed ID: 27154821	2016
A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells. Nature medicine\| PubMed ID: 27213817	2016
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of clinical investigation\| PubMed ID: 27294525	2016
Burning Fat Fuels Leukemic Stem Cell Heterogeneity. Cell stem cell\| PubMed ID: 27392217	2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemi... PloS one\| PubMed ID: 27428079	2016
Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution. Nature genetics\| PubMed ID: 27526324	2016
Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Oncotarget\| PubMed ID: 27732946	2016
The role of mutations in the cohesin complex in acute myeloid leukemia. International journal of hematology\| PubMed ID: 27796738	2017
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. Nature\| PubMed ID: 27820943	2016
Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML. Cancer cell\| PubMed ID: 27846387	2016
Biology and relevance of human acute myeloid leukemia stem cells. Blood\| PubMed ID: 28159741	2017
Optimizing Next-Generation AML Therapy: Activity of Mutant IDH2 Inhibitor AG-221 in Preclinical Models. Cancer discovery\| PubMed ID: 28461409	2017
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Nature communications\| PubMed ID: 28561042	2017
Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer discovery\| PubMed ID: 28729405	2017
Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia. Frontiers in oncology\| PubMed ID: 29164062	2017
Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal. EBioMedicine\| PubMed ID: 29203377	2017
Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation. Cell\| PubMed ID: 29706549	2018
Targeting Cancer Stemness in the Clinic: From Hype to Hope. Cell stem cell\| PubMed ID: 30595497	2019
CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30655315	2019
Induced pluripotent stem cell modeling of malignant hematopoiesis. Experimental hematology\| PubMed ID: 30659850	2019
Data mining for mutation-specific targets in acute myeloid leukemia. Leukemia\| PubMed ID: 30728456	2019
First-in-Human, First-in-Class Phase I Trial of the Anti-CD47 Antibody Hu5F9-G4 in Patients With Advanced Cancers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 30811285	2019
No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML. Cancer cell\| PubMed ID: 30889374	2019
Single-cell lineage tracing by endogenous mutations enriched in transposase accessible mitochondrial DNA. eLife\| PubMed ID: 30958261	2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index. Scientific reports\| PubMed ID: 31727951	2019
The phosphatidylethanolamine biosynthesis pathway provides a new target for cancer chemotherapy. Journal of hepatology\| PubMed ID: 31760071	2020
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia. Nature biotechnology\| PubMed ID: 31792411	2019
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion. Experimental hematology\| PubMed ID: 31874780	2019
A Dysregulated DNA Methylation Landscape Linked to Gene Expression in MLL-Rearranged AML. Epigenetics\| PubMed ID: 32114880	2020
IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia. Science translational medicine\| PubMed ID: 32269167	2020
Targeting macrophage checkpoint inhibitor SIRPα for anticancer therapy. JCI insight\| PubMed ID: 32427583	2020
Sufficiency for inducible Caspase-9 safety switch in human pluripotent stem cells and disease cells. Gene therapy\| PubMed ID: 32704085	2019
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia. Nature cancer\| PubMed ID: 33123685	2020
CD34 expression does not correlate with immunophenotypic stem cell or progenitor content in human cord blood products. Blood advances\| PubMed ID: 33136125	2020
Targeting LSCs: Peeling Back the Curtain on the Metabolic Complexities of AML. Cell stem cell\| PubMed ID: 33157042	2020
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells. Nature communications\| PubMed ID: 33473139	2021
Clonal Hematopoiesis: From Mechanisms to Clinical Intervention. Cancer discovery\| PubMed ID: 34407958	2021
Monocytic differentiation and AHR signaling as Primary Nodes of BET Inhibitor Response in Acute Myeloid Leukemia. Blood cancer discovery\| PubMed ID: 34568834	2021
NOT-Gated CD93 CAR T Cells Effectively Target AML with Minimized Endothelial Cross-Reactivity. Blood cancer discovery\| PubMed ID: 34778803	2021
Clonal architecture predicts clinical outcomes and drug sensitivity in acute myeloid leukemia. Nature communications\| PubMed ID: 34903734	2021
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. Nature medicine\| PubMed ID: 35027753	2022
CytofIn enables integrated analysis of public mass cytometry datasets using generalized anchors. Nature communications\| PubMed ID: 35177627	2022
The Cell Type-Specific 5hmC Landscape and Dynamics of Healthy Human Hematopoiesis and TET2-Mutant Preleukemia. Blood cancer discovery\| PubMed ID: 35532363	2022
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1. Nature cancer\| PubMed ID: 35817829	2022
Single-cell genomics in AML: extending the frontiers of AML research. Blood\| PubMed ID: 35926108	2023
Dysregulated Lipid Synthesis by Oncogenic IDH1 Mutation Is a Targetable Synthetic Lethal Vulnerability. Cancer discovery\| PubMed ID: 36355448	2023
Reprogramming Cancer into Antigen Presenting Cells as a Novel Immunotherapy. Cancer discovery\| PubMed ID: 36856575	2023
An agenda to advance research in MDS: A TOP 10 Priority List from the first international workshop in MDS (iwMDS). Blood advances\| PubMed ID: 36260702	2022
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36897988	2023
Current landscape of translational and clinical research in myelodysplastic syndromes/neoplasms (MDS): Proceedings from the 1 International Workshop on MDS (iwMDS) Of the International Conso... Blood reviews\| PubMed ID: 36934059	2023
Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia. Blood cancer discovery\| PubMed ID: 37067914	2023
RUNX1 loss renders hematopoietic and leukemic cells dependent on IL-3 and sensitive to JAK inhibition. The Journal of clinical investigation\| PubMed ID: 37581927	2023
Immune Surveillance of Acute Myeloid Leukemia Is Mediated by HLA-Presented Antigens on Leukemia Progenitor Cells. Blood cancer discovery\| PubMed ID: 37847741	2023
Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia. bioRxiv : the preprint server for biology\| PubMed ID: 37873452	2023