co-fermentation-marsdenia-tenacissima-with-ganoderma-lucidum-anti

Co-Fermentation of <em>Marsdenia tenacissima</em> with <em>Ganoderma lucidum</em> and Anti-Lung Cancer Effect of the Fermentation Products

Marsdenia tenacissima (Roxb.) Wight et Arn. (MT), as a traditional Chinese and Dai herbal medicine, has anti-inflammatory, antibacterial, and antitumor ...

Minzu University of China

Key Laboratory of Ethnomedicine (Minzu University of China)

Lung cancer is one of the malignant tumors with the fastest incidence rate and mortality growth and the greatest threat to human health and life.  is an antitumor of Chinese medicine. However,  has low bioavailability in the human body and most of its main active substances are aglycones, such as Tenacigenin A, Tenacigenin B. This study aims to produce biotransformation products rich in pungent saponins by using  as a fermentation medium of . Non-targeted metabolomics analysis was carried out on the fermentation products after the optimization process. A total of 249 differential metabolites were detected, and the content of saponins increased from 0.1% to 0.41% and most of them were tenacigenin. Furthermore, the biotransformation of C steroidal glycosides in  was the central reaction in this fermentation process. Pharmacodynamics resewed that the anticancer effect of  was significantly enhanced after fermentation, mainly through inhibiting the growth and apoptosis of cancer cells.

Zhiguang Zhang

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