Roosmarijn E. Vandenbroucke

VIB Center for Inflammation Research, VIB

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 4	2022

Other Publications

Article	Year
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 20010917	2010
Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression. Cytokine & growth factor reviews\| PubMed ID: 21388856	2011
The first MMP in sepsis. EMBO molecular medicine\| PubMed ID: 21591260	2011
Matrix metalloproteinases as drug targets in ischemia/reperfusion injury. Drug discovery today\| PubMed ID: 21745586	2011
Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1. Cytokine & growth factor reviews\| PubMed ID: 21962830	2011
Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. The Journal of clinical investigation\| PubMed ID: 23676465	2013
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO molecular medicine\| PubMed ID: 23723167	2013
Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis. PloS one\| PubMed ID: 24339869	2013
Antisense oligonucleotides against TNFR1 prevent toxicity of TNF/IFNγ treatment in mouse tumor models. International journal of cancer\| PubMed ID: 24382818	2014
An acute phase protein ready to go therapeutic for sepsis. EMBO molecular medicine\| PubMed ID: 24408964	2014
A new angle on blood-CNS interfaces: a role for connexins? FEBS letters\| PubMed ID: 24631535	2014
Choose your models wisely: how different murine bone marrow-derived dendritic cell protocols influence the success of nanoparticulate vaccines in vitro. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 24960224	2014
Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 25310532	2014
Is there new hope for therapeutic matrix metalloproteinase inhibition? Nature reviews. Drug discovery\| PubMed ID: 25376097	2014
An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17. Cytokine & growth factor reviews\| PubMed ID: 25434285	2015
Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. The Journal of biological chemistry\| PubMed ID: 25538244	2015
Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25911755	2015
Clinical implications of leukocyte infiltration at the choroid plexus in (neuro)inflammatory disorders. Drug discovery today\| PubMed ID: 25979470	2015
Glucocorticoid-induced microRNA-511 protects against TNF by down-regulating TNFR1. EMBO molecular medicine\| PubMed ID: 25995337	2015
Therapeutic implications of the choroid plexus-cerebrospinal fluid interface in neuropsychiatric disorders. Brain, behavior, and immunity\| PubMed ID: 26116435	2015
Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice. Immunity\| PubMed ID: 26163370	2015
Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice. European journal of immunology\| PubMed ID: 26173741	2015
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26377465	2015
Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase. Mediators of inflammation\| PubMed ID: 26451076	2015
Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases. Mediators of inflammation\| PubMed ID: 26538832	2015
Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier. The Journal of clinical investigation\| PubMed ID: 26619118	2016
Development and Validation of a Small Single-domain Antibody That Effectively Inhibits Matrix Metalloproteinase 8. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 26775809	2016
Topical imiquimod yields systemic effects due to unintended oral uptake. Scientific reports\| PubMed ID: 26818707	2016
Into rather unexplored terrain-transcellular transport across the blood-brain barrier. Glia\| PubMed ID: 26852907	2016
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 27072025	2016
Nanobodies as therapeutics: big opportunities for small antibodies. Drug discovery today\| PubMed ID: 27080147	2016
The effect of aging on brain barriers and the consequences for Alzheimer's disease development. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 27143113	2016
Efficient analysis of mouse genome sequences reveal many nonsense variants. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27147605	2016
The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier. Neural regeneration research\| PubMed ID: 27212900	2016
Caloric restriction: beneficial effects on brain aging and Alzheimer's disease. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 27240590	2016
With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions. Mechanisms of ageing and development\| PubMed ID: 27450180	2016
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO molecular medicine\| PubMed ID: 27596437	2016
Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability. Nature communications\| PubMed ID: 27653841	2016
Mouse models of ageing and their relevance to disease. Mechanisms of ageing and development\| PubMed ID: 27717883	2016
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. International journal of molecular sciences\| PubMed ID: 27809288	2016
A Hidden Epithelial Barrier in the Brain with a Central Role in Regulating Brain Homeostasis. Implications for Aging. Annals of the American Thoracic Society\| PubMed ID: 28005425	2016
Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor. Gastroenterology\| PubMed ID: 28642198	2017
TNFR1 inhibition with a Nanobody protects against EAE development in mice. Scientific reports\| PubMed ID: 29057962	2017
Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis. Critical care medicine\| PubMed ID: 29095202	2018
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and barriers of the CNS\| PubMed ID: 29110676	2017
The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection. Brain, behavior, and immunity\| PubMed ID: 29258921	2018
Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017. Fluids and barriers of the CNS\| PubMed ID: 29329565	2018
Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease. EMBO molecular medicine\| PubMed ID: 29472246	2018
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice. The Journal of clinical investigation\| PubMed ID: 29746256	2018
A New Venue of TNF Targeting. International journal of molecular sciences\| PubMed ID: 29751683	2018
Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis. Shock (Augusta, Ga.)\| PubMed ID: 30124596	2019
The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond. Human mutation\| PubMed ID: 30668888	2019
Choroid plexus tumor necrosis factor receptor 1: A new neuroinflammatory piece of the complex Alzheimer's disease puzzle. Neural regeneration research\| PubMed ID: 30804238	2019
A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment. Nature neuroscience\| PubMed ID: 31061494	2019
Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain. The EMBO journal\| PubMed ID: 31304985	2019
Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine. Vaccines\| PubMed ID: 31450775	2019
Interferons: A molecular switch between damage and repair in ageing and Alzheimer's disease. Mechanisms of ageing and development\| PubMed ID: 31541624	2019
Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock. Scientific reports\| PubMed ID: 31719598	2019
Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop. Journal of extracellular vesicles\| PubMed ID: 31762963	2019
A Study of Cecal Ligation and Puncture-Induced Sepsis in Tissue-Specific Tumor Necrosis Factor Receptor 1-Deficient Mice. Frontiers in immunology\| PubMed ID: 31787972	2019
Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. Neurobiology of aging\| PubMed ID: 32008854	2020
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury. Glia\| PubMed ID: 32645232	2020
High-precision isotopic analysis of Mg and Ca in biological samples using multi-collector ICP-mass spectrometry after their sequential chromatographic isolation - Application to the characte... Analytica chimica acta\| PubMed ID: 32892933	2020
Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences. Cells\| PubMed ID: 33203181	2020
and the Potential Role in Neurological Disorders: There Is More Than . Frontiers in immunology\| PubMed ID: 33633723	2020
Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature neuroscience\| PubMed ID: 33782623	2021
Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion. Cells\| PubMed ID: 34207405	2021
Effect of Endotoxemia Induced by Intraperitoneal Injection of Lipopolysaccharide on the Mg isotopic Composition of Biofluids and Tissues in Mice. Frontiers in medicine\| PubMed ID: 34368182	2021
Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease. Acta neuropathologica communications\| PubMed ID: 34425919	2021
The power of imaging to understand extracellular vesicle biology in vivo. Nature methods\| PubMed ID: 34446922	2021
Extracellular Vesicles: A Double-Edged Sword in Sepsis. Pharmaceuticals (Basel, Switzerland)\| PubMed ID: 34451925	2021
The neurogliovascular unit in hepatic encephalopathy. JHEP reports : innovation in hepatology\| PubMed ID: 34611619	2021
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles. Nature biomedical engineering\| PubMed ID: 34616047	2021
Low-grade peripheral inflammation affects brain pathology in the Appmouse model of Alzheimer's disease. Acta neuropathologica communications\| PubMed ID: 34620254	2021
Involvement of the Choroid Plexus in the Pathogenesis of Niemann-Pick Disease Type C. Frontiers in cellular neuroscience\| PubMed ID: 34720883	2021
Gastric Infection Partially Protects against Neurotoxicity in A 6-OHDA Parkinson's Disease Mouse Model. International journal of molecular sciences\| PubMed ID: 34768765	2021
Special delEVery: Extracellular Vesicles as Promising Delivery Platform to the Brain. Biomedicines\| PubMed ID: 34829963	2021
Anti-Inflammatory Mesenchymal Stromal Cell-Derived Extracellular Vesicles Improve Pathology in Niemann-Pick Type C Disease. Biomedicines\| PubMed ID: 34944681	2021
Fighting fire with fire: The immune system might be key in our fight against Alzheimer's disease. Drug discovery today\| PubMed ID: 35032668	2022
The Impact of Systemic Inflammation on Alzheimer's Disease Pathology. Frontiers in immunology\| PubMed ID: 35069578	2021
The tremendous biomedical potential of bacterial extracellular vesicles. Trends in biotechnology\| PubMed ID: 35581020	2022
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature immunology\| PubMed ID: 35618831	2022
High-Precision Isotopic Analysis of Cu and Fe Multi-Collector Inductively Coupled Plasma-Mass Spectrometry Reveals Lipopolysaccharide-Induced Inflammatory Effects in Blood Plasma and Brain ... Frontiers in chemistry\| PubMed ID: 35783204	2022
Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis. JCI insight\| PubMed ID: 35881483	2022
Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease. Advanced drug delivery reviews\| PubMed ID: 35952829	2022
Recent insights into viral infections as a trigger and accelerator in alzheimer's disease. Drug discovery today\| PubMed ID: 35987492	2022
Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation. Immunity\| PubMed ID: 36228615	2022
A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation. Scientific reports\| PubMed ID: 36266427	2022
Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics. Biomaterials\| PubMed ID: 36302306	2022