Thirumala-Devi Kanneganti

Department of Immunology, St. Jude Children's Research Hospital

Affiliated withSt. Jude Children's Research Hospital

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 18	2023

Other Publications

Article	Year
Differential role of the NLRP3 inflammasome in infection and tumorigenesis. Immunology\| PubMed ID: 30666624	2019
The role of inflammasome modulation in virulence. Virulence\| PubMed ID: 22546900	2012
NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature\| PubMed ID: 22763455	2012
Membrane damage during Listeria monocytogenes infection triggers a caspase-7 dependent cytoprotective response. PLoS pathogens\| PubMed ID: 22807671	2012
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 ... The Journal of biological chemistry\| PubMed ID: 22898816	2012
IL-1 family cytokines trigger sterile inflammatory disease. Frontiers in immunology\| PubMed ID: 23087690	2012
Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3. Arthritis research & therapy\| PubMed ID: 23148704	2012
Innate immune pathways in host defense. Mediators of inflammation\| PubMed ID: 23326019	2012
Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β). The Journal of biological chemistry\| PubMed ID: 23386602	2013
Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nature immunology\| PubMed ID: 23525089	2013
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3. Nature\| PubMed ID: 23708968	2013
NLRP6 in infection and inflammation. Microbes and infection\| PubMed ID: 23811097	2013
The expanding role of NLRs in antiviral immunity. Immunological reviews\| PubMed ID: 23947344	2013
Unsolved Mysteries in NLR Biology. Frontiers in immunology\| PubMed ID: 24062750	2013
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection. Frontiers in cellular and infection microbiology\| PubMed ID: 24273750	2013
Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24347638	2014
Critical role for inflammasome-independent IL-1β production in osteomyelitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24395792	2014
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24453255	2014
Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nature communications\| PubMed ID: 24492532	2014
Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation. PLoS pathogens\| PubMed ID: 24722226	2014
RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell\| PubMed ID: 24813850	2014
Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease. Seminars in immunopathology\| PubMed ID: 24838628	2014
Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis. Mucosal immunology\| PubMed ID: 24850431	2014
Nucleotide oligomerization and binding domain 2-dependent dendritic cell activation is necessary for innate immunity and optimal CD8+ T Cell responses to influenza A virus infection. Journal of virology\| PubMed ID: 24872587	2014
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis. Nature\| PubMed ID: 25043000	2014
Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection. PLoS pathogens\| PubMed ID: 25254654	2014
Dietary modulation of the microbiome affects autoinflammatory disease. Nature\| PubMed ID: 25274309	2014
Cutting edge: STING mediates protection against colorectal tumorigenesis by governing the magnitude of intestinal inflammation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25320273	2014
Novel roles for caspase-8 in IL-1β and inflammasome regulation. The American journal of pathology\| PubMed ID: 25451151	2015
Mitochondria: diversity in the regulation of the NLRP3 inflammasome. Trends in molecular medicine\| PubMed ID: 25500014	2015
Drak2 is not required for tumor surveillance and suppression. International immunology\| PubMed ID: 25568303	2015
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25605939	2015
MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. The Journal of clinical investigation\| PubMed ID: 25607842	2015
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis. Nature communications\| PubMed ID: 25607885	2015
Cutting edge: SHARPIN is required for optimal NLRP3 inflammasome activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25637014	2015
An NLRP3 inflammasome-triggered Th2-biased adaptive immune response promotes leishmaniasis. The Journal of clinical investigation\| PubMed ID: 25689249	2015
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. Cell host & microbe\| PubMed ID: 25704009	2015
Inflammasome control of viral infection. Current opinion in virology\| PubMed ID: 25771504	2015
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nature immunology\| PubMed ID: 25774715	2015
The inflammasome: firing up innate immunity. Immunological reviews\| PubMed ID: 25879279	2015
Regulation of inflammasome activation. Immunological reviews\| PubMed ID: 25879280	2015
The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. Immunity\| PubMed ID: 25888258	2015
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells. Nature genetics\| PubMed ID: 25938942	2015
A20 is a regulator of necroptosis. Nature immunology\| PubMed ID: 25988900	2015
Innate immune recognition of mtDNA--an undercover signal? Cell metabolism\| PubMed ID: 26039443	2015
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell\| PubMed ID: 26095253	2015
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature cell biology\| PubMed ID: 26098576	2015
Innate immunity against Leishmania infections. Cellular microbiology\| PubMed ID: 26249747	2015
NLRP12 in autoimmune diseases. Oncotarget\| PubMed ID: 26343520	2015
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation. Scientific reports\| PubMed ID: 26412089	2015
Gasdermin D: the long-awaited executioner of pyroptosis. Cell research\| PubMed ID: 26482951	2015
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity. European journal of immunology\| PubMed ID: 26626159	2016
Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nature reviews. Immunology\| PubMed ID: 26655628	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Type I Interferon Keeps IL-1β in Check. Cell host & microbe\| PubMed ID: 26962937	2016
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis. Mucosal immunology\| PubMed ID: 27007676	2017
Immune responses against protozoan parasites: a focus on the emerging role of Nod-like receptors. Cellular and molecular life sciences : CMLS\| PubMed ID: 27032699	2016
DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota. Pathogens and disease\| PubMed ID: 27056948	2016
NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27071119	2016
Autophagy suppresses host adaptive immune responses toward Borrelia burgdorferi. Journal of leukocyte biology\| PubMed ID: 27101991	2016
Microbiota and caspase-1/caspase-8 regulate IL-1β-mediated bone disease. Gut microbes\| PubMed ID: 27148834	2016
Autoinflammatory Skin Disorders: The Inflammasomme in Focus. Trends in molecular medicine\| PubMed ID: 27267764	2016
DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection. Scientific reports\| PubMed ID: 27291827	2016
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation. The Journal of cell biology\| PubMed ID: 27325789	2016
Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation. Journal of leukocyte biology\| PubMed ID: 27418355	2017
Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection. The Journal of experimental medicine\| PubMed ID: 27551156	2016
Rewiring cellular metabolism via the AKT/mTOR pathway contributes to host defence against Mycobacterium tuberculosis in human and murine cells. European journal of immunology\| PubMed ID: 27624090	2016
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell\| PubMed ID: 27693356	2016
IL-33 regulates the IgA-microbiota axis to restrain IL-1α-dependent colitis and tumorigenesis. The Journal of clinical investigation\| PubMed ID: 27775548	2016
Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B. Autophagy\| PubMed ID: 27786577	2016
Distinct role of IL-1β in instigating disease in Sharpin mice. Scientific reports\| PubMed ID: 27892465	2016
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Science immunology\| PubMed ID: 27917412	2016
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature\| PubMed ID: 27951586	2016
IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever. The American journal of pathology\| PubMed ID: 27998728	2017
Inflammasomes and Cancer. Cancer immunology research\| PubMed ID: 28093447	2017
Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28130494	2017
Regulation and functions of NLRP3 inflammasome during influenza virus infection. Molecular immunology\| PubMed ID: 28169000	2017
Differential roles of caspase-1 and caspase-11 in infection and inflammation. Scientific reports\| PubMed ID: 28345580	2017
Inflammasome activation by nucleic acids and nucleosomes in sterile inflammation… or is it sterile? The FEBS journal\| PubMed ID: 28374568	2017
Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease. Immunity\| PubMed ID: 28410990	2017
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases. Immunological reviews\| PubMed ID: 28462526	2017
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28468974	2017
Mechanisms governing inflammasome activation, assembly and pyroptosis induction. International immunology\| PubMed ID: 28531279	2017
NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer. Cell cycle (Georgetown, Tex.)\| PubMed ID: 28598238	2017
Deficiency of the NOD-Like Receptor NLRC5 Results in Decreased CD8 T Cell Function and Impaired Viral Clearance. Journal of virology\| PubMed ID: 28615208	2017
ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death. The Journal of experimental medicine\| PubMed ID: 28634194	2017
War on Viruses: LC3 Recruits GTPases. Cell host & microbe\| PubMed ID: 28704655	2017
Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. Infection and immunity\| PubMed ID: 28784930	2017
Inflammatory Bowel Disease and the NLRP3 Inflammasome. The New England journal of medicine\| PubMed ID: 28813221	2017
Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics. Scientific reports\| PubMed ID: 28904353	2017
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28947539	2017
Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins. mBio\| PubMed ID: 28974614	2017
Inflammatory cell death in intestinal pathologies. Immunological reviews\| PubMed ID: 29027223	2017
Recent advances in inflammasome biology. Current opinion in immunology\| PubMed ID: 29128729	2018
cGAMP: A tale of two signals. The Journal of experimental medicine\| PubMed ID: 29150429	2017
Inflammasome activation and assembly at a glance. Journal of cell science\| PubMed ID: 29196474	2017
Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis. Gastroenterology\| PubMed ID: 29203393	2018
Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29203515	2018
ZBP1: Innate Sensor Regulating Cell Death and Inflammation. Trends in immunology\| PubMed ID: 29236673	2018
Mechanisms and Consequences of Inflammasome Activation. Journal of molecular biology\| PubMed ID: 29247654	2018
Function and regulation of IL-1α in inflammatory diseases and cancer. Immunological reviews\| PubMed ID: 29247991	2018
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4. Cell reports\| PubMed ID: 29262324	2017
IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 29321274	2018
The Absence of NOD1 Enhances Killing of Through Modulation of Dectin-1 Expression. Frontiers in immunology\| PubMed ID: 29326692	2017
Gasdermin D Flashes an Exit Signal for IL-1. Immunity\| PubMed ID: 29343431	2018
Stressed-out ROS take a silent death route. Nature immunology\| PubMed ID: 29348507	2018
ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. The American journal of pathology\| PubMed ID: 29353059	2018
TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. The Journal of experimental medicine\| PubMed ID: 29500178	2018
Food for Training-Western Diet and Inflammatory Memory. Cell metabolism\| PubMed ID: 29514058	2018
Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection. Cell reports\| PubMed ID: 29562174	2018
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell\| PubMed ID: 29576451	2018
ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. The Journal of clinical investigation\| PubMed ID: 29629899	2018
The inflammasome starts rolling. Nature reviews. Immunology\| PubMed ID: 29858587	2018
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation. Immunity\| PubMed ID: 29958799	2018
Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nature communications\| PubMed ID: 29980664	2018
Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice. Cell death and differentiation\| PubMed ID: 30038386	2019
Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative . Cell death discovery\| PubMed ID: 30062052	2018
Cutting Edge: Dysregulated CARD9 Signaling in Neutrophils Drives Inflammation in a Mouse Model of Neutrophilic Dermatoses. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30082320	2018
Lung γδ T Cells Mediate Protective Responses during Neonatal Influenza Infection that Are Associated with Type 2 Immunity. Immunity\| PubMed ID: 30170813	2018
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer. Immunity\| PubMed ID: 30231985	2018
Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice. PLoS biology\| PubMed ID: 30388107	2018
Gasdermin D Promotes AIM2 Inflammasome Activation and Is Required for Host Protection against . Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30404813	2018
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy. The Journal of clinical investigation\| PubMed ID: 30457980	2019
Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection. Nature microbiology\| PubMed ID: 30510167	2019
Is Inflammasome a Potential Target of Prophylaxis in Rheumatic Heart Disease? Circulation\| PubMed ID: 30571276	2018
The signposts and winding roads to immunity and inflammation. Nature reviews. Immunology\| PubMed ID: 30602731	2019
Sterile particle-induced inflammation is mediated by macrophages releasing IL-33 through a Bruton's tyrosine kinase-dependent pathway. Nature materials\| PubMed ID: 30664693	2019
Fueling Ketone Metabolism Quenches Salt-Induced Hypertension. Trends in endocrinology and metabolism: TEM\| PubMed ID: 30670332	2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging. Cell reports\| PubMed ID: 30673616	2019
Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae. PloS one\| PubMed ID: 30794604	2019
Diverging inflammasome signals in tumorigenesis and potential targeting. Nature reviews. Cancer\| PubMed ID: 30842595	2019
On the Road to Discovering the Elusive Executioner of Pyroptosis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 30885986	2019
Cell death-mediated cytokine release and its therapeutic implications. The Journal of experimental medicine\| PubMed ID: 31186281	2019
The NLRC4 inflammasome requires IRF8-dependent production of NAIPs. Cell stress\| PubMed ID: 31225480	2018
Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. European journal of immunology\| PubMed ID: 31372985	2019
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature\| PubMed ID: 31511697	2019
Inflammasomes in the pathophysiology of autoinflammatory syndromes. Journal of leukocyte biology\| PubMed ID: 31608507	2020
Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells. Journal of virology\| PubMed ID: 31694942	2020
The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis. The Journal of biological chemistry\| PubMed ID: 31719149	2020
Hidden Aspects of Valency in Immune System Regulation. Trends in immunology\| PubMed ID: 31734148	2019
Targeting Apoptosis Inhibition to Activate Antitumor Immunity. Trends in immunology\| PubMed ID: 31735511	2019
Inflammasomes and the fine line between defense and disease. Current opinion in immunology\| PubMed ID: 31837596	2020
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis). Frontiers in cellular and infection microbiology\| PubMed ID: 31850239	2019
Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease. The Journal of experimental medicine\| PubMed ID: 31869420	2020
Pyroptosis in Antiviral Immunity. Current topics in microbiology and immunology\| PubMed ID: 31875268	2019
Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation\| PubMed ID: 32002713	2020
Caspases in Cell Death, Inflammation, and Pyroptosis. Annual review of immunology\| PubMed ID: 32017655	2020
DNA Sensing in the Innate Immune Response. Physiology (Bethesda, Md.)\| PubMed ID: 32027562	2020
Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion. PLoS pathogens\| PubMed ID: 32150572	2020
Toward targeting inflammasomes: insights into their regulation and activation. Cell research\| PubMed ID: 32152420	2020
Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation. Cellular & molecular immunology\| PubMed ID: 32203187	2021
IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32205422	2020
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense. Cell\| PubMed ID: 32298652	2020
The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. The Journal of biological chemistry\| PubMed ID: 32350114	2020
DDX3X Sits at the Crossroads of Liquid-Liquid and Prionoid Phase Transitions Arbitrating Life and Death Cell Fate Decisions in Stressed Cells. DNA and cell biology\| PubMed ID: 32397752	2020
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis. Immunity\| PubMed ID: 32428502	2020
Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis). Frontiers in cellular and infection microbiology\| PubMed ID: 32547960	2020
DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma. Developmental cell\| PubMed ID: 32553121	2020
Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer. JCI insight\| PubMed ID: 32554929	2020
PANoptosis components, regulation, and implications. Aging\| PubMed ID: 32575071	2020
The PANoptosome: A Deadly Protein Complex Driving Pyroptosis, Apoptosis, and Necroptosis (PANoptosis). Frontiers in cellular and infection microbiology\| PubMed ID: 32582562	2020
ZBP1: A STARGᐰTE to decode the biology of Z-nucleic acids in disease. The Journal of experimental medicine\| PubMed ID: 32584411	2020
The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis). Immunological reviews\| PubMed ID: 32729116	2020
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection. The Journal of biological chemistry\| PubMed ID: 32763970	2020
PANoptosis in microbial infection. Current opinion in microbiology\| PubMed ID: 32829024	2021
NLRP12 in innate immunity and inflammation. Molecular aspects of medicine\| PubMed ID: 32838963	2020
Intracellular innate immune receptors: Life inside the cell. Immunological reviews\| PubMed ID: 32856334	2020
A comprehensive guide to studying inflammasome activation and cell death. Nature protocols\| PubMed ID: 32895525	2020
Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles. Trends in molecular medicine\| PubMed ID: 32948447	2020
Acute IL-4 Governs Pathogenic T Cell Responses during Infection. ImmunoHorizons\| PubMed ID: 32948646	2020
RIPK3 Promotes Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32989095	2020
ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). The Journal of biological chemistry\| PubMed ID: 33109609	2020
Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. bioRxiv : the preprint server for biology\| PubMed ID: 33140051	2020
Coronaviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines. Trends in immunology\| PubMed ID: 33153908	2020
The innate immune system and cell death in autoinflammatory and autoimmune disease. Current opinion in immunology\| PubMed ID: 33242752	2020
Galactosaminogalactan activates the inflammasome to provide host protection. Nature\| PubMed ID: 33268895	2020
Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell\| PubMed ID: 33278357	2021
RIPK1 Distinctly Regulates -Induced Inflammatory Cell Death, PANoptosis. ImmunoHorizons\| PubMed ID: 33310881	2020
Publisher Correction: Galactosaminogalactan activates the inflammasome to provide host protection. Nature\| PubMed ID: 33349706	2021
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense. Journal of cellular immunology\| PubMed ID: 33426542	2020
Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins. Nature communications\| PubMed ID: 33479228	2021
Advances in Understanding Activation and Function of the NLRC4 Inflammasome. International journal of molecular sciences\| PubMed ID: 33494299	2021
Metabolic regulation of pyroptotic cell death expands the therapeutic landscape for treating inflammatory disease. Signal transduction and targeted therapy\| PubMed ID: 33514689	2021
A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma. Cancer research\| PubMed ID: 33619117	2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy\| PubMed ID: 33634751	2021
Sepsis take-out: Inhibiting bacterial deliveries. Immunity\| PubMed ID: 33691128	2021
NLRP3 inflammasome in cancer and metabolic diseases. Nature immunology\| PubMed ID: 33707781	2021
Role of inflammasomes/pyroptosis and PANoptosis during fungal infection. PLoS pathogens\| PubMed ID: 33735255	2021
DDX3X coordinates host defense against influenza virus by activating the NLRP3 inflammasome and type I interferon response. The Journal of biological chemistry\| PubMed ID: 33766561	2021
Intestinal tête-à-tête: helminths blunt immunity against flaviviruses. Cell research\| PubMed ID: 33846568	2021
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines. Nature immunology\| PubMed ID: 33963333	2021
CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes. bioRxiv : the preprint server for biology\| PubMed ID: 34075382	2021
TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule Assembly. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34145059	2021
Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis. mBio\| PubMed ID: 34154417	2021
The 'cytokine storm': molecular mechanisms and therapeutic prospects. Trends in immunology\| PubMed ID: 34217595	2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth. ImmunoHorizons\| PubMed ID: 34290111	2021
AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature\| PubMed ID: 34471287	2021
From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways. Computational and structural biotechnology journal\| PubMed ID: 34504660	2021
PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field. Journal of molecular biology\| PubMed ID: 34537233	2022
Programming inflammatory cell death for therapy. Pharmacology & therapeutics\| PubMed ID: 34619283	2022
Cutting Edge: Caspase-8 Is a Linchpin in Caspase-3 and Gasdermin D Activation to Control Cell Death, Cytokine Release, and Host Defense during Influenza A Virus Infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 34663620	2021
NLRP3 inflammasome activation triggers gasdermin D-independent inflammation. Science immunology\| PubMed ID: 34678046	2021
ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell reports\| PubMed ID: 34686350	2021
The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice. European journal of immunology\| PubMed ID: 34694641	2022
Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections. The Journal of biological chemistry\| PubMed ID: 34740613	2021
Integrated stress response restricts macrophage necroptosis. Life science alliance\| PubMed ID: 34764207	2022
Fungal cell wall components modulate our immune system. Cell surface (Amsterdam, Netherlands)\| PubMed ID: 34825116	2021
It's just a phase: NLRP6 phase separations drive signaling. Cell research\| PubMed ID: 34837058	2022
Fostering experimental and computational synergy to modulate hyperinflammation. Trends in immunology\| PubMed ID: 34844849	2022
induces NLRP3 inflammasome activation and caspase-8-mediated apoptosis of macrophages to promote lethal anthrax. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34996874	2022
Innate immunity: the first line of defense against SARS-CoV-2. Nature immunology\| PubMed ID: 35105981	2022
The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis. Cancers\| PubMed ID: 35205671	2022
NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis. ImmunoHorizons\| PubMed ID: 35301258	2022
It's All in the PAN: Crosstalk, Plasticity, Redundancies, Switches, and Interconnectedness Encompassed by PANoptosis Underlying the Totality of Cell Death-Associated Biological Effects. Cells\| PubMed ID: 35563804	2022
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Science immunology\| PubMed ID: 35587515	2022
DEAD/H-Box Helicases in Immunity, Inflammation, Cell Differentiation, and Cell Death and Disease. Cells\| PubMed ID: 35626643	2022
Innate Immune Cell Death in Neuroinflammation and Alzheimer's Disease. Cells\| PubMed ID: 35741014	2022
A BAF-fling connection to RIPK1. Cell research\| PubMed ID: 35787662	2022
Inflammasome signaling in colorectal cancer. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 36150688	2023
Single cell analysis of PANoptosome cell death complexes through an expansion microscopy method. Cellular and molecular life sciences : CMLS\| PubMed ID: 36169732	2022
Molecular mechanism of RIPK1 and caspase-8 in homeostatic type I interferon production and regulation. Cell reports\| PubMed ID: 36198273	2022
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 36253067	2022
Pancancer transcriptomic profiling identifies key PANoptosis markers as therapeutic targets for oncology. NAR cancer\| PubMed ID: 36329783	2022
Humans pIKK-up NLRP3 to skip NEK7. Trends in immunology\| PubMed ID: 36404209	2022
Innate immunity, cytokine storm, and inflammatory cell death in COVID-19. Journal of translational medicine\| PubMed ID: 36419185	2022
Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression. Frontiers in immunology\| PubMed ID: 36505497	2022
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines. Pathogens (Basel, Switzerland)\| PubMed ID: 36558734	2022
AIM2 sensors mediate immunity to infection in hepatocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36595704	2023
CD47 halts -deficient neutrophils from provoking lethal inflammation. Science advances\| PubMed ID: 36608128	2023