Rocky S. Tuan

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine

Affiliated withUniversity of Pittsburgh School of Medicine The Chinese University of Hong Kong

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2023

Other Publications

Article	Year
Detection of periprosthetic infections with use of ribosomal RNA-based polymerase chain reaction. The Journal of bone and joint surgery. American volume\| PubMed ID: 20194324	2010
Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert opinion on biological therapy\| PubMed ID: 20218920	2010
Hypertrophy in mesenchymal stem cell chondrogenesis: effect of TGF-beta isoforms and chondrogenic conditioning. Cells, tissues, organs\| PubMed ID: 20407224	2010
Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype. Stem cell research & therapy\| PubMed ID: 20565707	2010
Activin A expression regulates multipotency of mesenchymal progenitor cells. Stem cell research & therapy\| PubMed ID: 20637060
Novel strategies in tendon and ligament tissue engineering: Advanced biomaterials and regeneration motifs. Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT\| PubMed ID: 20727171	2010
PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes. Osteoarthritis and cartilage\| PubMed ID: 21087676	2011
Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling. Journal of cellular physiology\| PubMed ID: 21437907	2012
Cytokine expression in muscle following traumatic injury. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 21452302	2011
Delayed fracture healing in growth differentiation factor 5-deficient mice: a pilot study. Clinical orthopaedics and related research\| PubMed ID: 21590487	2011
Comparison of minimally invasive direct anterior versus posterior total hip arthroplasty based on inflammation and muscle damage markers. The Journal of bone and joint surgery. American volume\| PubMed ID: 21915544	2011
Stabilization of proteins by nanoencapsulation in sugar-glass for tissue engineering and drug delivery applications. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 21953536	2011
Biological responses of human mesenchymal stem cells to titanium wear debris particles. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 22083964	2011
Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head. Stem cell research & therapy\| PubMed ID: 22356811	2012
Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential. Biomaterials\| PubMed ID: 22459197	2012
Stem Cell Research & Therapy in 2012. Stem cell research & therapy\| PubMed ID: 22548746	2012
Mesenchymal progenitor cells derived from traumatized muscle enhance neurite growth. Journal of tissue engineering and regenerative medicine\| PubMed ID: 22552971	2013
Mesenchymal stem cell therapy for attenuation of scar formation during wound healing. Stem cell research & therapy\| PubMed ID: 22668751	2012
The promise and challenges of stem cell-based therapies for skeletal diseases: stem cell applications in skeletal medicine: potential, cell sources and characteristics, and challenges of cli... BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 22948900	2013
Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials\| PubMed ID: 23092861	2013
Polyphenols suppress hydrogen peroxide-induced oxidative stress in human bone-marrow derived mesenchymal stem cells. Journal of cellular biochemistry\| PubMed ID: 23192437	2013
Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem cells translational medicine\| PubMed ID: 23197639	2012
Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives. Stem cells translational medicine\| PubMed ID: 23197783	2012
Regenerative medicine in 2012: the coming of age of musculoskeletal tissue engineering. Nature reviews. Rheumatology\| PubMed ID: 23321611	2013
Effect of parathyroid hormone-related protein in an in vitro hypertrophy model for mesenchymal stem cell chondrogenesis. International orthopaedics\| PubMed ID: 23371427	2013
Three years of Stem Cell Research & Therapy. Stem cell research & therapy\| PubMed ID: 23635482	2013
The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration. Stem cell research & therapy\| PubMed ID: 23899671	2013
Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix. Biomaterials\| PubMed ID: 24044998	2013
Tendon and ligament regeneration and repair: clinical relevance and developmental paradigm. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 24078497	2013
Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs. Matrix biology : journal of the International Society for Matrix Biology\| PubMed ID: 24140982	2014
Cellular therapy in bone-tendon interface regeneration. Organogenesis\| PubMed ID: 24326955	2014
Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning. Stem cells translational medicine\| PubMed ID: 24436440	2014
High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer. BioTechniques\| PubMed ID: 24502798	2014
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. Tissue engineering. Part A\| PubMed ID: 24575844	2014
Functional comparison of human-induced pluripotent stem cell-derived mesenchymal cells and bone marrow-derived mesenchymal stromal cells from the same donor. Stem cells and development\| PubMed ID: 24625206	2014
Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β. Molecular pharmaceutics\| PubMed ID: 24830762	2014
Functional cartilage repair capacity of de-differentiated, chondrocyte- and mesenchymal stem cell-laden hydrogels in vitro. Osteoarthritis and cartilage\| PubMed ID: 24887551	2014
Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 24994814	2014
Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis research & therapy\| PubMed ID: 25164150	2014
Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors. Journal of cellular and molecular medicine\| PubMed ID: 25250510	2014
Characterization of bone marrow-derived mesenchymal stem cells in aging. Bone\| PubMed ID: 25445445	2015
Origin and function of cartilage stem/progenitor cells in osteoarthritis. Nature reviews. Rheumatology\| PubMed ID: 25536487	2015
Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog. Developmental biology\| PubMed ID: 25596336	2015
Fiber diameter and seeding density influence chondrogenic differentiation of mesenchymal stem cells seeded on electrospun poly(ε-caprolactone) scaffolds. Biomedical materials (Bristol, England)\| PubMed ID: 25634427	2015
Platelet-Rich Plasma Inhibits Mechanically Induced Injury in Chondrocytes. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association\| PubMed ID: 25769480	2015
Molecular diagnostics. The Journal of the American Academy of Orthopaedic Surgeons\| PubMed ID: 25808967	2015
In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold. Tissue engineering. Part A\| PubMed ID: 25813386	2015
Development of a Spring-Loaded Impact Device to Deliver Injurious Mechanical Impacts to the Articular Cartilage Surface. Cartilage\| PubMed ID: 26069650	2013
Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. Frontiers in bioengineering and biotechnology\| PubMed ID: 26347860	2015
Stem Cells in Skeletal Tissue Engineering: Technologies and Models. Current stem cell research & therapy\| PubMed ID: 26423296	2016
Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 26445383	2016
Cartilage stem/progenitor cells are activated in osteoarthritis via interleukin-1β/nerve growth factor signaling. Arthritis research & therapy\| PubMed ID: 26577823	2015
Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis. Stem cell research & therapy\| PubMed ID: 26626726	2015
Expression of Concern: Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure. Stem cell research & therapy\| PubMed ID: 26644000	2015
Nascent osteoblast matrix inhibits osteogenesis of human mesenchymal stem cells in vitro. Stem cell research & therapy\| PubMed ID: 26696301	2015
Antibiotic-tolerant Staphylococcus aureus Biofilm Persists on Arthroplasty Materials. Clinical orthopaedics and related research\| PubMed ID: 26831479	2016
Polymerase Chain Reaction molecular diagnostic technology for monitoring chronic osteomyelitis. Journal of experimental orthopaedics\| PubMed ID: 26914754	2014
Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering. Acta biomaterialia\| PubMed ID: 26945631	2016
From embryonic development to human diseases: The functional role of caveolae/caveolin. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 26991990	2016
Human Cartilage-Derived Progenitor Cells From Committed Chondrocytes for Efficient Cartilage Repair and Regeneration. Stem cells translational medicine\| PubMed ID: 27130221	2016
Catabolic effects of endothelial cell-derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 27246627	2016
Prenatal substance use and developmental disorders: Overview and highlights. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 27345012	2016
Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. Development (Cambridge, England)\| PubMed ID: 27387871	2016
Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote. Connective tissue research\| PubMed ID: 27459585	2017
Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies. Stem cell research & therapy\| PubMed ID: 27612948	2016
Augmented repair of radial meniscus tear with biomimetic electrospun scaffold: an in vitro mechanical analysis. Journal of experimental orthopaedics\| PubMed ID: 27624439	2016
Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study. Connective tissue research\| PubMed ID: 27726454	2017
Prenatal exposure to environmental factors and congenital limb defects. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 27768243	2016
Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells. Tissue engineering. Part A\| PubMed ID: 27809678	2017
Anatomical region-dependent enhancement of 3-dimensional chondrogenic differentiation of human mesenchymal stem cells by soluble meniscus extracellular matrix. Acta biomaterialia\| PubMed ID: 27876676	2017
Region-Specific Effect of the Decellularized Meniscus Extracellular Matrix on Mesenchymal Stem Cell-Based Meniscus Tissue Engineering. The American journal of sports medicine\| PubMed ID: 27895039	2017
A unified birth defects research. Birth defects research\| PubMed ID: 27905204	2017
Efficacy of thermoresponsive, photocrosslinkable hydrogels derived from decellularized tendon and cartilage extracellular matrix for cartilage tissue engineering. Journal of tissue engineering and regenerative medicine\| PubMed ID: 28486778	2018
Birth Defects: Etiology, screening, and detection. Birth defects research\| PubMed ID: 28568741	2017
Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells. Stem cell research & therapy\| PubMed ID: 28583182	2017
Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness. Acta biomaterialia\| PubMed ID: 28611002	2017
One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction. Molecular therapy. Methods & clinical development\| PubMed ID: 29018836	2017
Neurotrophic support by traumatized muscle-derived multipotent progenitor cells: Role of endothelial cells and Vascular Endothelial Growth Factor-A. Stem cell research & therapy\| PubMed ID: 29029631	2017
Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration. Frontiers in bioengineering and biotechnology\| PubMed ID: 29164111	2017
Neurotrophically Induced Mesenchymal Progenitor Cells Derived from Induced Pluripotent Stem Cells Enhance Neuritogenesis via Neurotrophin and Cytokine Production. Stem cells translational medicine\| PubMed ID: 29215199	2018
Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo. Acta biomaterialia\| PubMed ID: 29317369	2018
3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon-derived stem cells through a PI3K/AKT signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29596022	2018
Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. Stem cell research & therapy\| PubMed ID: 29615119	2018
Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology. Stem cell research & therapy\| PubMed ID: 29678192	2018
TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW. Current pathobiology reports\| PubMed ID: 29967714	2018
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. Biomaterials\| PubMed ID: 29980291	2019
Musculoskeletal regeneration research network: A global initiative. Journal of orthopaedic translation\| PubMed ID: 30035054	2015
Effect of Platelet-Rich Plasma on Chondrogenic Differentiation of Adipose- and Bone Marrow-Derived Mesenchymal Stem Cells. Tissue engineering. Part A\| PubMed ID: 30036140	2018
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30104374	2018
Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β. Acta biomaterialia\| PubMed ID: 30458242	2019
Enhanced repair of meniscal hoop structure injuries using an aligned electrospun nanofibrous scaffold combined with a mesenchymal stem cell-derived tissue engineered construct. Biomaterials\| PubMed ID: 30471629	2019
Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway. Biomaterials\| PubMed ID: 30544046	2019
Conduits harnessing spatially controlled cell-secreted neurotrophic factors improve peripheral nerve regeneration. Biomaterials\| PubMed ID: 30857644	2019
Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect. Journal of tissue engineering and regenerative medicine\| PubMed ID: 31066519	2019
A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold. Stem cells international\| PubMed ID: 31149016	2019
Role of NGF-TrkA signaling in calcification of articular chondrocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 31238006	2019
Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. Biomaterials\| PubMed ID: 31310952	2019
Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold. Stem cell research & therapy\| PubMed ID: 31412905	2019
Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production. Journal of orthopaedic translation\| PubMed ID: 31508317	2019
A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization during Osteochondral Defect Repair in a Porcine Model. International journal of molecular sciences\| PubMed ID: 31627374	2019
Modeling appendicular skeletal cartilage development with modified high-density micromass cultures of adult human bone marrow-derived mesenchymal progenitor cells. Stem cell research & therapy\| PubMed ID: 31842986	2019
Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs. Frontiers in bioengineering and biotechnology\| PubMed ID: 31921815	2019
Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance. Journal of biomedical materials research. Part A\| PubMed ID: 31925910	2020
Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta biomaterialia\| PubMed ID: 32035282	2020
Chondroinductive factor-free chondrogenic differentiation of human mesenchymal stem cells in graphene oxide-incorporated hydrogels. Journal of materials chemistry. B\| PubMed ID: 32254371	2018
TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification. Bone\| PubMed ID: 32259685	2020
Tendon-derived extracellular matrix induces mesenchymal stem cell tenogenesis via an integrin/transforming growth factor-β crosstalk-mediated mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 32301551	2020
Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional Bone Model. Tissue engineering. Part A\| PubMed ID: 32312178	2020
Gel and cells: A promising reparative strategy for degenerated intervertebral discs. EBioMedicine\| PubMed ID: 32335373	2020
Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical ... Advanced biosystems\| PubMed ID: 32648682	2019
Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus. Stem cell research & therapy\| PubMed ID: 32680544	2020
Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors . Biomolecules\| PubMed ID: 32709032	2020
Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models. Biology\| PubMed ID: 32751156	2020
Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice. Stem cells translational medicine\| PubMed ID: 32785966	2020
Mechanism of traumatic heterotopic ossification: In search of injury-induced osteogenic factors. Journal of cellular and molecular medicine\| PubMed ID: 32853465	2020
Dead muscle tissue promotes dystrophic calcification by lowering circulating TGF-β1 level. Bone & joint research\| PubMed ID: 33135464	2020
Current Models for Development of Disease-Modifying Osteoarthritis Drugs. Tissue engineering. Part C, Methods\| PubMed ID: 33403944	2021
Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling. Handbook of experimental pharmacology\| PubMed ID: 33471201	2021
Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 33617078	2021
Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries. Science translational medicine\| PubMed ID: 33627488	2021
Development of a large animal rabbit model for chronic periprosthetic joint infection. Bone & joint research\| PubMed ID: 33641351	2021
An in vitro chondro-osteo-vascular triphasic model of the osteochondral complex. Biomaterials\| PubMed ID: 33798958	2021
The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles. Biomedicines\| PubMed ID: 34062822	2021
Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells. Stem cell research & therapy\| PubMed ID: 34127047	2021
Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. BMC developmental biology\| PubMed ID: 34225660	2021
A High-Throughput Mechanical Activator for Cartilage Engineering Enables Rapid Screening of in vitro Response of Tissue Models to Physiological and Supra-Physiological Loads. Cells, tissues, organs\| PubMed ID: 34261061	2022
Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway. Biomaterials\| PubMed ID: 34464823	2021
Dextran sulfate-amplified extracellular matrix deposition promotes osteogenic differentiation of mesenchymal stem cells. Acta biomaterialia\| PubMed ID: 34875356	2022
Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles. International journal of molecular sciences\| PubMed ID: 34884641	2021
Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 35436042	2022
Tenogenic induction of human adipose-derived stem cells by soluble tendon extracellular matrix: composition and transcriptomic analyses. Stem cell research & therapy\| PubMed ID: 35906661	2022
Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models. Stem cell research & therapy\| PubMed ID: 35927702	2022
Aberrant Expression of and in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors. Cells\| PubMed ID: 35954211	2022
Towards establishing human body-on-a-chip systems. Stem cell research & therapy\| PubMed ID: 35987699	2022
Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential. Trends in biotechnology\| PubMed ID: 35995600	2022
Polyphenols suppress inducible oxidative stress in human osteoarthritic and bovine chondrocytes. Osteoarthritis and cartilage open\| PubMed ID: 36474689	2020
Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma. Current pathobiology reports\| PubMed ID: 36506709	2018