Hang Lin

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine

Affiliated withUniversity of Pittsburgh School of Medicine University of Pittsburgh Swanson School of Engineering

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2023

Other Publications

Article	Year
Influence of decellularized matrix derived from human mesenchymal stem cells on their proliferation, migration and multi-lineage differentiation potential. Biomaterials\| PubMed ID: 22459197	2012
Application of visible light-based projection stereolithography for live cell-scaffold fabrication with designed architecture. Biomaterials\| PubMed ID: 23092861	2013
Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix. Biomaterials\| PubMed ID: 24044998	2013
Cartilage tissue engineering application of injectable gelatin hydrogel with in situ visible-light-activated gelation capability in both air and aqueous solution. Tissue engineering. Part A\| PubMed ID: 24575844	2014
Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1β. Molecular pharmaceutics\| PubMed ID: 24830762	2014
Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Experimental biology and medicine (Maywood, N.J.)\| PubMed ID: 24994814	2014
In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold. Tissue engineering. Part A\| PubMed ID: 25813386	2015
Projection Stereolithographic Fabrication of Human Adipose Stem Cell-Incorporated Biodegradable Scaffolds for Cartilage Tissue Engineering. Frontiers in bioengineering and biotechnology\| PubMed ID: 26347860	2015
Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering. Acta biomaterialia\| PubMed ID: 26945631	2016
Tendon-Derived Extracellular Matrix Enhances Transforming Growth Factor-β3-Induced Tenogenic Differentiation of Human Adipose-Derived Stem Cells. Tissue engineering. Part A\| PubMed ID: 27809678	2017
Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness. Acta biomaterialia\| PubMed ID: 28611002	2017
One-Step Fabrication of Bone Morphogenetic Protein-2 Gene-Activated Porous Poly-L-Lactide Scaffold for Bone Induction. Molecular therapy. Methods & clinical development\| PubMed ID: 29018836	2017
Mesenchymal stem cell-derived extracellular matrix enhances chondrogenic phenotype of and cartilage formation by encapsulated chondrocytes in vitro and in vivo. Acta biomaterialia\| PubMed ID: 29317369	2018
Influence of cholesterol/caveolin-1/caveolae homeostasis on membrane properties and substrate adhesion characteristics of adult human mesenchymal stem cells. Stem cell research & therapy\| PubMed ID: 29615119	2018
Bone marrow mesenchymal stem cells: Aging and tissue engineering applications to enhance bone healing. Biomaterials\| PubMed ID: 29980291	2019
Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-β. Acta biomaterialia\| PubMed ID: 30458242	2019
Engineering hyaline cartilage from mesenchymal stem cells with low hypertrophy potential via modulation of culture conditions and Wnt/β-catenin pathway. Biomaterials\| PubMed ID: 30544046	2019
Optimization of photocrosslinked gelatin/hyaluronic acid hybrid scaffold for the repair of cartilage defect. Journal of tissue engineering and regenerative medicine\| PubMed ID: 31066519	2019
Transplantation of adult spinal cord tissue: Transection spinal cord repair and potential clinical translation. Science China. Life sciences\| PubMed ID: 31124004	2019
A Bioactive Cartilage Graft of IGF1-Transduced Adipose Mesenchymal Stem Cells Embedded in an Alginate/Bovine Cartilage Matrix Tridimensional Scaffold. Stem cells international\| PubMed ID: 31149016	2019
The efficacy and safety of tranexamic acid for reducing blood loss following simultaneous bilateral total knee arthroplasty: a multicenter retrospective study. BMC musculoskeletal disorders\| PubMed ID: 31299945	2019
Robust bone regeneration through endochondral ossification of human mesenchymal stem cells within their own extracellular matrix. Biomaterials\| PubMed ID: 31310952	2019
Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold. Stem cell research & therapy\| PubMed ID: 31412905	2019
Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production. Journal of orthopaedic translation\| PubMed ID: 31508317	2019
A Cellularized Biphasic Implant Based on a Bioactive Silk Fibroin Promotes Integration and Tissue Organization during Osteochondral Defect Repair in a Porcine Model. International journal of molecular sciences\| PubMed ID: 31627374	2019
Infiltration and In-Tissue Polymerization of Photocross-Linked Hydrogel for Effective Fixation of Implants into Cartilage-An In Vitro Study. ACS omega\| PubMed ID: 31737812	2019
Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs. Frontiers in bioengineering and biotechnology\| PubMed ID: 31921815	2019
Incorporating silica-coated graphene in bioceramic nanocomposites to simultaneously enhance mechanical and biological performance. Journal of biomedical materials research. Part A\| PubMed ID: 31925910	2020
Acceleration of chondrogenic differentiation of human mesenchymal stem cells by sustained growth factor release in 3D graphene oxide incorporated hydrogels. Acta biomaterialia\| PubMed ID: 32035282	2020
Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior. Arthritis research & therapy\| PubMed ID: 32087740	2020
Chondroinductive factor-free chondrogenic differentiation of human mesenchymal stem cells in graphene oxide-incorporated hydrogels. Journal of materials chemistry. B\| PubMed ID: 32254371	2018
TGF-β1 plays a protective role in glucocorticoid-induced dystrophic calcification. Bone\| PubMed ID: 32259685	2020
Macrophage Effects on Mesenchymal Stem Cell Osteogenesis in a Three-Dimensional Bone Model. Tissue engineering. Part A\| PubMed ID: 32312178	2020
Condensation-Driven Chondrogenesis of Human Mesenchymal Stem Cells within Their Own Extracellular Matrix: Formation of Cartilage with Low Hypertrophy and Physiologically Relevant Mechanical ... Advanced biosystems\| PubMed ID: 32648682	2019
Adipose Tissue-Derived Stem Cells Retain Their Adipocyte Differentiation Potential in Three-Dimensional Hydrogels and Bioreactors . Biomolecules\| PubMed ID: 32709032	2020
Pathogenesis of Osteoarthritis: Risk Factors, Regulatory Pathways in Chondrocytes, and Experimental Models. Biology\| PubMed ID: 32751156	2020
Injectable BMP-2 gene-activated scaffold for the repair of cranial bone defect in mice. Stem cells translational medicine\| PubMed ID: 32785966	2020
Mesenchymal stem cell-derived extracellular matrix (mECM): a bioactive and versatile scaffold for musculoskeletal tissue engineering. Biomedical materials (Bristol, England)\| PubMed ID: 32906098	2020
Role of mitochondria in mediating chondrocyte response to mechanical stimuli. Life sciences\| PubMed ID: 33086121	2020
Dead muscle tissue promotes dystrophic calcification by lowering circulating TGF-β1 level. Bone & joint research\| PubMed ID: 33135464	2020
Current Models for Development of Disease-Modifying Osteoarthritis Drugs. Tissue engineering. Part C, Methods\| PubMed ID: 33403944	2021
Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling. Handbook of experimental pharmacology\| PubMed ID: 33471201	2021
Enhancing the potential of aged human articular chondrocytes for high-quality cartilage regeneration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 33617078	2021
Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From Expanded Human Chondrocytes. Frontiers in bioengineering and biotechnology\| PubMed ID: 33996787	2021
The Effects of Macrophage Phenotype on Osteogenic Differentiation of MSCs in the Presence of Polyethylene Particles. Biomedicines\| PubMed ID: 34062822	2021
Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs. Science China. Life sciences\| PubMed ID: 34109475	2022
Dynamic loading enhances chondrogenesis of human chondrocytes within a biodegradable resilient hydrogel. Biomaterials science\| PubMed ID: 34109952	2021
Caveolin-1 mediates soft scaffold-enhanced adipogenesis of human mesenchymal stem cells. Stem cell research & therapy\| PubMed ID: 34127047	2021
Urolithin A Protects Chondrocytes From Mechanical Overloading-Induced Injuries. Frontiers in pharmacology\| PubMed ID: 34220525	2021
Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway. Biomaterials\| PubMed ID: 34464823	2021
Novel role of estrogen receptor-α on regulating chondrocyte phenotype and response to mechanical loading. Osteoarthritis and cartilage\| PubMed ID: 34767957	2022
Macrophages Modulate the Function of MSC- and iPSC-Derived Fibroblasts in the Presence of Polyethylene Particles. International journal of molecular sciences\| PubMed ID: 34884641	2021
Role of Canonical Wnt/β-Catenin Pathway in Regulating Chondrocytic Hypertrophy in Mesenchymal Stem Cell-Based Cartilage Tissue Engineering. Frontiers in cell and developmental biology\| PubMed ID: 35141220	2022
Engineering pre-vascularized bone-like tissue from human mesenchymal stem cells through simulating endochondral ossification. Biomaterials\| PubMed ID: 35259584	2022
Human Mesenchymal Stem Cell-Derived Miniature Joint System for Disease Modeling and Drug Testing. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 35436042	2022
Generation of hyaline-like cartilage tissue from human mesenchymal stromal cells within the self-generated extracellular matrix. Acta biomaterialia\| PubMed ID: 35779770	2022
Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models. Stem cell research & therapy\| PubMed ID: 35927702	2022
Aberrant Expression of and in Infrapatellar Fat Pad-Derived ASCs from Pre-Diabetic Donors. Cells\| PubMed ID: 35954211	2022
Synovial joint-on-a-chip for modeling arthritis: progress, pitfalls, and potential. Trends in biotechnology\| PubMed ID: 35995600	2022
Potential Methods of Targeting Cellular Aging Hallmarks to Reverse Osteoarthritic Phenotype of Chondrocytes. Biology\| PubMed ID: 36101377	2022
Experimental models to study osteoarthritis pain and develop therapeutics. Osteoarthritis and cartilage open\| PubMed ID: 36474784	2022
Differences in the intrinsic chondrogenic potential of human mesenchymal stromal cells and iPSC-derived multipotent cells. Clinical and translational medicine\| PubMed ID: 36536500	2022
PEG Reinforced Scaffold Promotes Uniform Distribution of Human MSC-Created Cartilage Matrix. Gels (Basel, Switzerland)\| PubMed ID: 36547318	2022
In vitro study to identify ligand-independent function of estrogen receptor-α in suppressing DNA damage-induced chondrocyte senescence. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 36622202	2023