Tomoaki Shirao

Department of Pharmacology, Gunma University

Affiliated withGunma University AlzMed, Inc.Gunma university

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 8929425	1996
Change in the shape of dendritic spines caused by overexpression of drebrin in cultured cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10234022	1999
A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization. Genomics\| PubMed ID: 11991718	2002
Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12878700	2003
[Synaptic development and abnormality at protein level]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology\| PubMed ID: 15484828	2004
Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions. Molecular and cellular neurosciences\| PubMed ID: 16054392	2005
Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts. Molecular and cellular neurosciences\| PubMed ID: 16368245	2006
Overexpression of drebrin A in immature neurons induces the accumulation of F-actin and PSD-95 into dendritic filopodia, and the formation of large abnormal protrusions. Molecular and cellular neurosciences\| PubMed ID: 16456930	2005
Differential effects of x-irradiation on immature and mature hippocampal neurons in vitro. Neuroscience letters\| PubMed ID: 16483715	2006
AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16492745	2006
Down-regulation of drebrin A expression suppresses synaptic targeting of NMDA receptors in developing hippocampal neurones. Journal of neurochemistry\| PubMed ID: 16635259	2006
Synaptic dysfunction and disruption of postsynaptic drebrin-actin complex: a study of neurological disorders accompanied by cognitive deficits. Neuroscience research\| PubMed ID: 17379343	2007
Increase in AMPA receptor-mediated miniature EPSC amplitude after chronic NMDA receptor blockade in cultured hippocampal neurons. Neuroscience letters\| PubMed ID: 17395372	2007
Drebrin a content correlates with spine head size in the adult mouse cerebral cortex. The Journal of comparative neurology\| PubMed ID: 17559090	2007
Role of actin cytoskeleton in dendritic spine morphogenesis. Neurochemistry international\| PubMed ID: 17590478	2007
Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice. The Journal of comparative neurology\| PubMed ID: 17912741	2007
Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. Journal of neurochemistry\| PubMed ID: 19222710	2009
Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. Journal of cell science\| PubMed ID: 19339553	2009
Three-dimensional distribution of Fos-positive neurons in the supramammillary nucleus of the rat exposed to novel environment. Neuroscience research\| PubMed ID: 19409426	2009
Drebrin a knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex. The Journal of comparative neurology\| PubMed ID: 19711416	2009
Effect of radiation on the development of immature hippocampal neurons in vitro. Radiation research\| PubMed ID: 19929418	2009
Chemico-genetic identification of drebrin as a regulator of calcium responses. The international journal of biochemistry & cell biology\| PubMed ID: 19948240	2010
Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons. Journal of radiation research\| PubMed ID: 20940520	2010
Role of cerebellar cortical protein synthesis in transfer of memory trace of cerebellum-dependent motor learning. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21677179	2011
Inhibitory role of inducible cAMP early repressor (ICER) in methamphetamine-induced locomotor sensitization. PloS one\| PubMed ID: 21738744	2011
Evidence for cell density affecting C2C12 myogenesis: possible regulation of myogenesis by cell-cell communication. Muscle & nerve\| PubMed ID: 22102468	2011
Regulation of myotube formation by the actin-binding factor drebrin. Skeletal muscle\| PubMed ID: 22152295	2011
X irradiation changes dendritic spine morphology and density through reduction of cytoskeletal proteins in mature neurons. Radiation research\| PubMed ID: 23578130	2013
Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors. Neuroscience letters\| PubMed ID: 23684573	2013
Actin filaments and microtubules in dendritic spines. Journal of neurochemistry\| PubMed ID: 23692384	2013
AMP-activated protein kinase counteracts brain-derived neurotrophic factor-induced mammalian target of rapamycin complex 1 signaling in neurons. Journal of neurochemistry\| PubMed ID: 23841933	2013
Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. Journal of neurochemistry\| PubMed ID: 24117785	2014
Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1. FEBS open bio\| PubMed ID: 24251100	2013
Myosin II ATPase activity mediates the long-term potentiation-induced exodus of stable F-actin bound by drebrin A from dendritic spines. PloS one\| PubMed ID: 24465547	2014
Cellular localization and dendritic function of rat isoforms of the SRF coactivator MKL1 in cortical neurons. Neuroreport\| PubMed ID: 24589521	2014
Phosphorylation of drebrin by cyclin-dependent kinase 5 and its role in neuronal migration. PloS one\| PubMed ID: 24637538	2014
Histone deacetylase mediates the decrease in drebrin cluster density induced by amyloid beta oligomers. Neurochemistry international\| PubMed ID: 25058791	2014
Comparison of the radiosensitivities of neurons and glial cells derived from the same rat brain. Experimental and therapeutic medicine\| PubMed ID: 25120594	2014
An inhibitory pathway controlling the gating mechanism of the mouse lateral amygdala revealed by voltage-sensitive dye imaging. Neuroscience letters\| PubMed ID: 25646995	2015
A novel role for drebrin in regulating progranulin bioactivity in bladder cancer. Oncotarget\| PubMed ID: 25839164	2015
Nuclear Translocation of Calcium/Calmodulin-dependent Protein Kinase IIδ3 Promoted by Protein Phosphatase-1 Enhances Brain-derived Neurotrophic Factor Expression in Dopaminergic Neurons. The Journal of biological chemistry\| PubMed ID: 26163515	2015
Early-stage development of human induced pluripotent stem cell-derived neurons. Journal of neuroscience research\| PubMed ID: 26346430	2015
X Irradiation Induces Acute Cognitive Decline via Transient Synaptic Dysfunction. Radiation research\| PubMed ID: 27023259	2016
The role of drebrin in dendritic spines. Molecular and cellular neurosciences\| PubMed ID: 28161364	2017
The role of drebrin in neurons. Journal of neurochemistry\| PubMed ID: 28199019	2017
Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28416666	2017
Drebrin E regulates neuroblast proliferation and chain migration in the adult brain. The European journal of neuroscience\| PubMed ID: 28833685	2017
General Introduction to Drebrin. Advances in experimental medicine and biology\| PubMed ID: 28865011	2017
Localization of Drebrin: Light Microscopy Study. Advances in experimental medicine and biology\| PubMed ID: 28865017	2017
Role of Drebrin in Synaptic Plasticity. Advances in experimental medicine and biology\| PubMed ID: 28865021	2017
Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain. Advances in experimental medicine and biology\| PubMed ID: 28865024	2017
Isoform-dependent Regulation of Drebrin Dynamics in Dendritic Spines. Neuroscience\| PubMed ID: 29522857	2018
CaMKIIβ is localized in dendritic spines as both drebrin-dependent and drebrin-independent pools. Journal of neurochemistry\| PubMed ID: 29675826	2018
Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction. Frontiers in cellular neuroscience\| PubMed ID: 30349460	2018
Association between decreased serum TBIL concentration and immediate memory impairment in schizophrenia patients. Scientific reports\| PubMed ID: 30733572	2019
Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons. Neurochemical research\| PubMed ID: 31037609	2019
Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay. Journal of pharmacological and toxicological methods\| PubMed ID: 31082488	2019
High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons. Journal of pharmacological and toxicological methods\| PubMed ID: 31271780	2019
X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity. Neuroscience research\| PubMed ID: 31711782	2020
Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. Epilepsia\| PubMed ID: 32662890	2020
Properties of primary cilia in melanin-concentrating hormone receptor 1-bearing hippocampal neurons in vivo and in vitro. Neurochemistry international\| PubMed ID: 33197527	2021
PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Communications biology\| PubMed ID: 33244074	2020
Soy Isoflavones Accelerate Glial Cell Migration GPER-Mediated Signal Transduction Pathway. Frontiers in endocrinology\| PubMed ID: 33250856	2020
Genetic Knockout of the Serotonin Reuptake Transporter Results in the Reduction of Dendritic Spines in In vitro Rat Cortical Neuronal Culture. Journal of molecular neuroscience : MN\| PubMed ID: 33403594	2021
NMDA receptor-dependent and -independent effects of natural compounds and crude drugs on synaptic states as revealed by drebrin imaging analysis. The European journal of neuroscience\| PubMed ID: 33851450	2021
Ciliary GPCR-based transcriptome as a key regulator of cilia length control. FASEB bioAdvances\| PubMed ID: 34485842	2021
Postsynaptic structure formation of human iPS cell-derived neurons takes longer than presynaptic formation during neural differentiation in vitro. Molecular brain\| PubMed ID: 34629097	2021
Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease. Biochemical and biophysical research communications\| PubMed ID: 35453040	2022
Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner. Neuroscience research\| PubMed ID: 36162735	2022