Timothy Block

Drexel University College of Medicine

Affiliated withDrexel University College of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2012

Other Publications

Article	Year
Virology\| PubMed ID: 12033761	2002
The Journal of general virology\| PubMed ID: 12075077	2002
Antiviral research\| PubMed ID: 12206880	2002
Journal of virology\| PubMed ID: 12208938	2002
Antimicrobial agents and chemotherapy\| PubMed ID: 12435712	2002
The Journal of general virology\| PubMed ID: 12466470	2002
Antiviral chemistry & chemotherapy\| PubMed ID: 12630678	2002
Journal of virology\| PubMed ID: 12692252	2003
Proteomics\| PubMed ID: 12748940	2003
Molecular & cellular proteomics : MCP\| PubMed ID: 12754305	2003
Oncogene\| PubMed ID: 12910247	2003
Journal of virology\| PubMed ID: 14581530	2003
Clinical chemistry\| PubMed ID: 14709652	2004
Methods in molecular medicine\| PubMed ID: 14762271	2004
Proteomics\| PubMed ID: 14997503	2004
The Journal of molecular diagnostics : JMD\| PubMed ID: 15096565	2004
Journal of virological methods\| PubMed ID: 15109821	2004
Antimicrobial agents and chemotherapy\| PubMed ID: 15155204	2004
Annals of the New York Academy of Sciences\| PubMed ID: 15251944	2004
Journal of virology\| PubMed ID: 15507596	2004
Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15642945	2005
Journal of the American Chemical Society\| PubMed ID: 15643858	2005
Journal of virological methods\| PubMed ID: 15664065	2005
Hepatology (Baltimore, Md.)\| PubMed ID: 15726646	2005
International journal of medical sciences\| PubMed ID: 15912187	2004
International journal of medical sciences\| PubMed ID: 15968337	2005
Journal of hepatology\| PubMed ID: 16137783	2005
Hepatitis B virus large and middle glycoproteins are degraded by a proteasome pathway in glucosidase-inhibited cells but not in cells with functional glucosidase enzyme. Journal of virology\| PubMed ID: 16188993	2005
Advances in experimental medicine and biology\| PubMed ID: 16400797	2005
Proteomic analysis of serum associated fucosylated glycoproteins in the development of primary hepatocellular carcinoma. Journal of proteome research\| PubMed ID: 16457596	2006
Does rapid oligomerization of hepatitis B envelope proteins play a role in resistance to proteasome degradation and enhance chronicity? DNA and cell biology\| PubMed ID: 16569195	2006
Antiviral research\| PubMed ID: 16724398	2006
Molecular & cellular proteomics : MCP\| PubMed ID: 16760258	2006
Antiviral research\| PubMed ID: 16780964	2006
Journal of virology\| PubMed ID: 16987974	2006
Journal of neurovirology\| PubMed ID: 17065130	2006
Antiviral chemistry & chemotherapy\| PubMed ID: 17176630	2006
Cancer biomarkers : section A of Disease markers\| PubMed ID: 17192038	2005
Molecular cancer therapeutics\| PubMed ID: 17237271	2007
Antiviral chemistry & chemotherapy\| PubMed ID: 17354651	2007
The role of the downstream signal sequences in the maturation of the HBV middle surface glycoprotein: development of a novel therapeutic vaccine candidate. Virology\| PubMed ID: 17462693	2007
Regulation of hepatitis B virus replication by the phosphatidylinositol 3-kinase-akt signal transduction pathway. Journal of virology\| PubMed ID: 17609269	2007
The degradation pathway for the HBV envelope proteins involves proteolysis prior to degradation via the cytosolic proteasome. Virology\| PubMed ID: 17716702	2007
Journal of clinical microbiology\| PubMed ID: 17728479	2007
Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation. Journal of virology\| PubMed ID: 17804499	2007
Journal of neurovirology\| PubMed ID: 17849314	2007
A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrobial agents and chemotherapy\| PubMed ID: 17875990	2007
Alpha interferon-induced antiviral response noncytolytically reduces replication defective adenovirus DNA in MDBK cells. Antiviral research\| PubMed ID: 17897730	2007
Molecular virology of hepatitis B virus for clinicians. Clinics in liver disease\| PubMed ID: 17981225	2007
N-linked glycosylation of the liver cancer biomarker GP73. Journal of cellular biochemistry\| PubMed ID: 18004786	2008
Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. Journal of virology\| PubMed ID: 18045939	2008
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus. Journal of virology\| PubMed ID: 18077728	2008
The degree of readiness of selected biomarkers for the early detection of hepatocellular carcinoma: notes from a recent workshop. Cancer biomarkers : section A of Disease markers\| PubMed ID: 18334731	2008
Apoptosis : an international journal on programmed cell death\| PubMed ID: 18347987	2008
Gastroenterology\| PubMed ID: 18457674	2008
Liver-specific microRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells. Journal of virology\| PubMed ID: 18550664	2008
Journal of clinical microbiology\| PubMed ID: 18753347	2008
Journal of clinical microbiology\| PubMed ID: 18799703	2008
Annals of the New York Academy of Sciences\| PubMed ID: 18837929	2008
Annals of the New York Academy of Sciences\| PubMed ID: 18837947	2008
Activation of pattern recognition receptor-mediated innate immunity inhibits the replication of hepatitis B virus in human hepatocyte-derived cells. Journal of virology\| PubMed ID: 18971270	2009
Mycopathologia\| PubMed ID: 19015951	2009
Inhibition of cellular alpha-glucosidases results in increased presentation of hepatitis B virus glycoprotein-derived peptides by MHC class I. Virology\| PubMed ID: 19091367	2009
Journal of proteome research\| PubMed ID: 19099421	2009
Fucosylated glycoproteins as markers of liver disease. Disease markers\| PubMed ID: 19126969	2008
Rapid and sensitive detection of hepatitis B virus 1762T/1764A double mutation from hepatocellular carcinomas using LNA-mediated PCR clamping and hybridization probes. Journal of virological methods\| PubMed ID: 19187787	2009
Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses. Antimicrobial agents and chemotherapy\| PubMed ID: 19223639	2009
Journal of clinical microbiology\| PubMed ID: 19386849	2009
Novel fucosylated biomarkers for the early detection of hepatocellular carcinoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 19454616	2009
Antiviral activity of geneticin against dengue virus. Antiviral research\| PubMed ID: 19501253	2009
Antiviral effect of interferon lambda against West Nile virus. Antiviral research\| PubMed ID: 19501257	2009
Journal of virology\| PubMed ID: 19864383	2010
Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses. Journal of virology\| PubMed ID: 19864387	2010
Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. Journal of virology\| PubMed ID: 20534863	2010
Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus. Journal of virology\| PubMed ID: 20610715	2010
Glucosidase inhibition enhances presentation of de-N-glycosylated hepatitis B virus epitopes by major histocompatibility complex class I in vitro and in woodchucks. Hepatology (Baltimore, Md.)\| PubMed ID: 20658465	2010
Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. PloS one\| PubMed ID: 20811639	2010
Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damaged. Journal of neurovirology\| PubMed ID: 20874012	2010
Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. Journal of virology\| PubMed ID: 20943977	2010
Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo. Antiviral research\| PubMed ID: 21073903	2011
Indoleamine 2,3-dioxygenase mediates the antiviral effect of gamma interferon against hepatitis B virus in human hepatocyte-derived cells. Journal of virology\| PubMed ID: 21084489	2011
Alkylated porphyrins have broad antiviral activity against hepadnaviruses, flaviviruses, filoviruses, and arenaviruses. Antimicrobial agents and chemotherapy\| PubMed ID: 21135183	2011
Inhibitors of endoplasmic reticulum alpha-glucosidases potently suppress hepatitis C virus virion assembly and release. Antimicrobial agents and chemotherapy\| PubMed ID: 21173177	2011
Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 21467232	2011
International journal of oncology\| PubMed ID: 21503570	2011
Ultrasensitive quantification of hepatitis B virus A1762T/G1764A mutant by a SimpleProbe PCR using a wild-type-selective PCR blocker and a primer-blocker-probe partial-overlap approach. Journal of clinical microbiology\| PubMed ID: 21562108	2011
Quantification of complex precore mutations of hepatitis B virus by SimpleProbe real time PCR and dual melting analysis. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology\| PubMed ID: 21665530	2011
Cancer biomarkers : section A of Disease markers\| PubMed ID: 21694465	2010
A locked nucleic acid clamp-mediated PCR assay for detection of a p53 codon 249 hotspot mutation in urine. The Journal of molecular diagnostics : JMD\| PubMed ID: 21726666	2011
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. Journal of medicinal chemistry\| PubMed ID: 21786803	2011
Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection. Antiviral research\| PubMed ID: 21854808	2011
Development of recombinant Aleuria aurantia lectins with altered binding specificities to fucosylated glycans. Biochemical and biophysical research communications\| PubMed ID: 21945439	2011
A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation. PloS one\| PubMed ID: 21969857	2011
Immunology\| PubMed ID: 22043941	2011
Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. PloS one\| PubMed ID: 22073196	2011
Hepatocellular carcinoma of the liver. Cancer biomarkers : section A of Disease markers\| PubMed ID: 22112485	2010
Quantitative dynamics of hepatitis B basal core promoter and precore mutants before and after HBeAg seroconversion. Journal of hepatology\| PubMed ID: 22173170	2012
Detection of hypermethylated vimentin in urine of patients with colorectal cancer. The Journal of molecular diagnostics : JMD\| PubMed ID: 22251609	2012
Increased levels of tetra-antennary N-linked glycan but not core fucosylation are associated with hepatocellular carcinoma tissue. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology\| PubMed ID: 22490318	2012
Impact of the location of CpG methylation within the GSTP1 gene on its specificity as a DNA marker for hepatocellular carcinoma. PloS one\| PubMed ID: 22536438	2012
Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner. Journal of neurovirology\| PubMed ID: 22581427	2012
Identification of disubstituted sulfonamide compounds as specific inhibitors of hepatitis B virus covalently closed circular DNA formation. Antimicrobial agents and chemotherapy\| PubMed ID: 22644022	2012
Design, synthesis, and biological evaluation of N-alkylated deoxynojirimycin (DNJ) derivatives for the treatment of dengue virus infection. Journal of medicinal chemistry\| PubMed ID: 22712544	2012
Characterization of the host factors required for hepadnavirus covalently closed circular (ccc) DNA formation. PloS one\| PubMed ID: 22912842	2012
Substance abuse, HIV-1 and hepatitis. Current HIV research\| PubMed ID: 22973853	2012
RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PloS one\| PubMed ID: 23056170	2012
The innate immune response to hepatitis B virus infection: implications for pathogenesis and therapy. Antiviral research\| PubMed ID: 23072881	2012
Interleukin-6 and oncostatin M are elevated in liver disease in conjunction with candidate hepatocellular carcinoma biomarker GP73. Cancer biomarkers : section A of Disease markers\| PubMed ID: 23144154	2012
Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells. PloS one\| PubMed ID: 23355882	2013
Defining the value proposition of biotech therapies. Biotechnology healthcare\| PubMed ID: 23372498	2004
Chronic hepatitis B: what should be the goal for new therapies? Antiviral research\| PubMed ID: 23391846	2013
Surrogate markers of efficacy for medical treatment of viral hepatitis. Biotechnology healthcare\| PubMed ID: 23396674	2004
Sulfamoylbenzamide derivatives inhibit the assembly of hepatitis B virus nucleocapsids. Journal of virology\| PubMed ID: 23576513	2013
Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses. Antiviral research\| PubMed ID: 23578725	2013
Altered functionality of anti-bacterial antibodies in patients with chronic hepatitis C virus infection. PloS one\| PubMed ID: 23750224	2013
Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions. Antiviral research\| PubMed ID: 23816430	2013
A southern blot assay for detection of hepatitis B virus covalently closed circular DNA from cell cultures. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23821267	2013
Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. PLoS pathogens\| PubMed ID: 23853601	2013
Total serum glycan analysis is superior to lectin-FLISA for the early detection of hepatocellular carcinoma. Proteomics. Clinical applications\| PubMed ID: 23857719	2013
Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes. PLoS pathogens\| PubMed ID: 24068929	2013
Improved biomarker performance for the detection of hepatocellular carcinoma by inclusion of clinical parameters. Proceedings. IEEE International Conference on Bioinformatics and Biomedicine\| PubMed ID: 24307972	2012
Interferon induction of IFITM proteins promotes infection by human coronavirus OC43. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24753610	2014
An interferon-beta promoter reporter assay for high throughput identification of compounds against multiple RNA viruses. Antiviral research\| PubMed ID: 24792753	2014
Viral resistance of MOGS-CDG patients implies a broad-spectrum strategy against acute virus infections. Antiviral therapy\| PubMed ID: 25318123	2015
Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan... Antimicrobial agents and chemotherapy\| PubMed ID: 25348530	2015
Differential methylation of the promoter and first exon of the RASSF1A gene in hepatocarcinogenesis. Hepatology research : the official journal of the Japan Society of Hepatology\| PubMed ID: 25382672	2015
STING agonists induce an innate antiviral immune response against hepatitis B virus. Antimicrobial agents and chemotherapy\| PubMed ID: 25512416	2015
Glycosylation and liver cancer. Advances in cancer research\| PubMed ID: 25727150	2015
Comprehensive DNA methylation analysis of hepatitis B virus genome in infected liver tissues. Scientific reports\| PubMed ID: 26000761	2015
Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents. Emerging microbes & infections\| PubMed ID: 26038444	2013
Data supporting updating estimates of the prevalence of chronic hepatitis B and C in the United States. Hepatology (Baltimore, Md.)\| PubMed ID: 26239816	2015
The Doylestown Algorithm: A Test to Improve the Performance of AFP in the Detection of Hepatocellular Carcinoma. Cancer prevention research (Philadelphia, Pa.)\| PubMed ID: 26712941	2016
Interferon-inducible ribonuclease ISG20 inhibits hepatitis B virus replication through directly binding to the epsilon stem-loop structure of viral RNA. PLoS pathogens\| PubMed ID: 28399146	2017
Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo. Antiviral research\| PubMed ID: 29253498	2018