anterior-cervical-hybrid-decompression-fusion-surgery-to-treat

Anterior Cervical Hybrid Decompression and Fusion Surgery to Treat Multilevel Cervical Spondylotic Myelopathy

Cervical spondylotic myelopathy (CSM) is a common disease resulting from intervertebral disc herniation, ossification of the posterior longitudinal ...

spinal-shortening-surgery-for-lumbosacral-nerve-bowstring-disease

Spinal Shortening Surgery for Lumbosacral Nerve Bowstring Disease: A Surgical Technique

Lumbosacral nerve bowstring disease (LNBD) is a syndrome of neurological symptoms caused by differences in the development speed of lumbosacral bone ...

induction-lumbar-disc-degeneration-rabbits-through-transabdominal

Induction of Lumbar Disc Degeneration in Rabbits Through a Transabdominal Approach

Lower back pain is an extremely common medical issue in populations worldwide. One of the main contributors to lower back pain is intervertebral disc ...

The University of Queensland

The University of Queensland. St Lucia

To investigate the correlation between tamoxifen (TAM) and lumbar intervertebral disc (IVD) degeneration (IVDD).

Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control Study.

This study aims to compare the outcomes between two anterior decompression and fusion techniques to treat multilevel cervical spondylotic myelopathy (MCSM).

Treatment of three-level cervical spondylotic myelopathy using ACDF or a combination of ACDF and ACCF.

To investigate the incidence and risk factors of lumbar plexus injury (LPI) after oblique lumbar interbody fusion (OLIF) surgery.

Incidence and risk factors of lumbar plexus injury in patients undergoing oblique lumbar interbody fusion surgery.

The purpose of this study is to investigate the clinical effect of posterior lumbar fusion surgery on patients who suffer from lumbar disc herniation concurrent with peroneal nerve paralysis.

The treatment effect of posterior lumbar fusion surgery on patients suffering from lumbar disc herniation concurrent with peroneal nerve paralysis.

Low back pain is the leading cause of disability, producing a substantial socio-economic burden on healthcare systems worldwide. Intervertebral disc (IVD) degeneration is a primary cause of lower back pain, and while regenerative therapies aimed at full functional recovery of the disc have been developed in recent years, no commercially available, approved devices or therapies for the regeneration of the IVD currently exist. In the development of these new approaches, numerous models for mechanical stimulation and preclinical assessment, including  cell studies using microfluidics,  organ studies coupled with bioreactors and mechanical testing rigs, and  testing in a variety of large and small animals, have emerged. These approaches have provided different capabilities, certainly improving the preclinical evaluation of these regenerative therapies, but challenges within the research environment, and compromises relating to non-representative mechanical stimulation and unrealistic test conditions, remain to be resolved. In this review, insights into the ideal characteristics of a disc model for the testing of IVD regenerative approaches are first assessed. Key learnings from , , and  IVD models under mechanical loading stimulation to date are presented alongside the merits and limitations of each model based on the physiological resemblance to the human IVD environment (biological and mechanical) as well as the possible feedback and output measurements for each approach. When moving from simplified  models to  and  approaches, the complexity increases resulting in less controllable models but providing a better representation of the physiological environment. Although cost, time, and ethical constraints are dependent on each approach, they escalate with the model complexity. These constraints are discussed and weighted as part of the characteristics of each model.

ArticleTotal : 3	Year
Publication title Cited by 4	2023
Publication title Cited by 2	2023
Publication title Cited by 1	2023

Article	Year
Correlation Analysis between Tamoxifen and Lumbar Intervertebral Disc Degeneration: A Retrospective Case-Control Study. Pain research & management\| PubMed ID: 35685675	2022
Treatment of three-level cervical spondylotic myelopathy using ACDF or a combination of ACDF and ACCF. Frontiers in surgery\| PubMed ID: 36189403	2022
Incidence and risk factors of lumbar plexus injury in patients undergoing oblique lumbar interbody fusion surgery. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society\| PubMed ID: 36370208	2023
The treatment effect of posterior lumbar fusion surgery on patients suffering from lumbar disc herniation concurrent with peroneal nerve paralysis. Frontiers in surgery\| PubMed ID: 36684276	2022
The role of biomechanical factors in models of intervertebral disc degeneration across multiple length scales. APL bioengineering\| PubMed ID: 37180733	2023

Samuel Rudd

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