Yoshiaki Nishimura

Laboratory of Molecular Microbiology, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2023

Other Publications

Article	Year
Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques. Journal of virology\| PubMed ID: 17093193	2007
Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus. Journal of virology\| PubMed ID: 10888632	2000
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous. Journal of virology\| PubMed ID: 11739702	2002
Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered... Journal of virology\| PubMed ID: 11836389	2002
Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating ... Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12370415	2002
Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinica... Journal of virology\| PubMed ID: 14512533	2003
Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14627745	2003
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15297611	2004
Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15911767	2005
CD8+ and CD20+ lymphocytes cooperate to control acute simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys: modulation by major histocompati... Journal of virology\| PubMed ID: 16282488	2005
Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques. Journal of virology\| PubMed ID: 17626082	2007
Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. PLoS pathogens\| PubMed ID: 19360097	2009
High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416840	2009
Noninvasive in vivo imaging of CD4 cells in simian-human immunodeficiency virus (SHIV)-infected nonhuman primates. Blood\| PubMed ID: 19417212	2009
Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells bu... Journal of virology\| PubMed ID: 19420078	2009
Neutralizing antibody titers conferring protection to macaques from a simian/human immunodeficiency virus challenge using the TZM-bl assay. AIDS research and human retroviruses\| PubMed ID: 20059398	2010
Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques. Journal of virology\| PubMed ID: 20147396	2010
Recombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDS. Journal of virology\| PubMed ID: 21813599	2011
The acute HIV infection: implications for intervention, prevention and development of an effective AIDS vaccine. Current opinion in virology\| PubMed ID: 21909345	2011
The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo. PloS one\| PubMed ID: 22043290	2011
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123961	2011
Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies. Journal of virology\| PubMed ID: 22647691	2012
Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23129652	2012
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science (New York, N.Y.)\| PubMed ID: 23661761	2013
Emergence of gp120 V3 variants confers neutralization resistance in an R5 simian-human immunodeficiency virus-infected macaque elite neutralizer that targets the N332 glycan of the human imm... Journal of virology\| PubMed ID: 23720719	2013
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature\| PubMed ID: 24172896	2013
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. The Journal of experimental medicine\| PubMed ID: 25155019	2014
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. The Journal of experimental medicine\| PubMed ID: 25385756	2014
Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nature communications\| PubMed ID: 25858157	2015
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. PLoS pathogens\| PubMed ID: 25996507	2015
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Science translational medicine\| PubMed ID: 26223303	2015
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature\| PubMed ID: 27120156	2016
Early antibody therapy can induce long-lasting immunity to SHIV. Nature\| PubMed ID: 28289286	2017
Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1. Cell host & microbe\| PubMed ID: 28799906	2017
A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nature medicine\| PubMed ID: 29662199	2018
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia. The Journal of experimental medicine\| PubMed ID: 32966579	2021
A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch. eLife\| PubMed ID: 33084569	2020
Concordance of immunological events between intrarectal and intravenous SHIVAD8-EO infection when assessed by Fiebig-equivalent staging. The Journal of clinical investigation\| PubMed ID: 34623326	2021
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Science translational medicine\| PubMed ID: 34818054	2021