Malcolm A. Martin

Laboratory of Molecular Microbiology, National Institutes of Health

Affiliated withNational Institutes of Health

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 12	2023

Other Publications

Article	Year
Common methionine-tryptic peptides near the amino-terminal end of primate papovavirus tumor antigens. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 206886	1978
Physical and biochemical properties of progressive pneumonia virus. Journal of virology\| PubMed ID: 4108574	1971
SV40 gene activity during lytic infection and in a series of SV40 transformed mouse cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4318346	1969
Detection and quantitation of simian virus 40 genetic material in abortively transformed BALB-3T3 clones (mice-diploid cells-virus equivalents). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4333038	1972
Patterns of Simian Virus 40 DNA transcription after acute infection of permissive and nonpermissive cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4340164	1972
Patterns of simian virus 40 deoxyribonucleic acid transcription. II. In transformed cells. Journal of virology\| PubMed ID: 4346281	1973
A general method of gene isolation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4352649	1973
In vitro transcription of the viral-specific sequences present in the chromatin of cells transformed by simian virus 40. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 4357875	1973
Reassortment of simian virus 40 DNA during serial undiluted passage. Journal of virology\| PubMed ID: 4359951	1973
Sedimentation properties of simian virus 40-specific ribonucleic acid present in green monkey cells during productive infection and in mouse cells undergoing abortive infection. Journal of virology\| PubMed ID: 5497892	1970
Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques. Journal of virology\| PubMed ID: 9420212	1998
Identification of determinants on a dualtropic human immunodeficiency virus type 1 envelope glycoprotein that confer usage of CXCR4. Journal of virology\| PubMed ID: 9499115	1998
Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. Molecular and cellular biology\| PubMed ID: 9566873	1998
Short- and long-term clinical outcomes in rhesus monkeys inoculated with a highly pathogenic chimeric simian/human immunodeficiency virus. Journal of virology\| PubMed ID: 10888632	2000
Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate. Journal of virology\| PubMed ID: 11000249	2000
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chi... Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11136236	2001
Polyvalent envelope glycoprotein vaccine elicits a broader neutralizing antibody response but is unable to provide sterilizing protection against heterologous Simian/human immunodeficiency v... Journal of virology\| PubMed ID: 11160726	2001
N-linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptor usage and cellular tropi... Journal of virology\| PubMed ID: 11390601	2001
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronous. Journal of virology\| PubMed ID: 11739702	2002
Determination of a statistically valid neutralization titer in plasma that confers protection against simian-human immunodeficiency virus challenge following passive transfer of high-titered... Journal of virology\| PubMed ID: 11836389	2002
Evolution of a human immunodeficiency virus type 1 variant with enhanced replication in pig-tailed macaque cells by DNA shuffling. Journal of virology\| PubMed ID: 11861859	2002
Amino acid deletions are introduced into the V2 region of gp120 during independent pathogenic simian immunodeficiency virus/HIV chimeric virus (SHIV) infections of rhesus monkeys generating ... Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12370415	2002
Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficien... Journal of virology\| PubMed ID: 12502833	2003
Characterization of pig-tailed macaque classical MHC class I genes: implications for MHC evolution and antigen presentation in macaques. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12847257	2003
Early control of highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys usually results in long-lasting asymptomatic clinica... Journal of virology\| PubMed ID: 14512533	2003
The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeys. Journal of leukocyte biology\| PubMed ID: 14595005	2003
Transfer of neutralizing IgG to macaques 6 h but not 24 h after SHIV infection confers sterilizing protection: implications for HIV-1 vaccine development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14627745	2003
Macrophage-tropic simian/human immunodeficiency virus chimeras use CXCR4, not CCR5, for infections of rhesus macaque peripheral blood mononuclear cells and alveolar macrophages. Journal of virology\| PubMed ID: 14645561	2003
Induction of disease by a molecularly cloned highly pathogenic simian immunodeficiency virus/human immunodeficiency virus chimera is multigenic. Journal of virology\| PubMed ID: 15113931	2004
Pig-tailed macaques (Macaca nemestrina) possess six MHC-E families that are conserved among macaque species: implication for their binding to natural killer receptor variants. Immunogenetics\| PubMed ID: 15148641	2004
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15297611	2004
Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15911767	2005
CD8+ and CD20+ lymphocytes cooperate to control acute simian immunodeficiency virus/human immunodeficiency virus chimeric virus infections in rhesus monkeys: modulation by major histocompati... Journal of virology\| PubMed ID: 16282488	2005
Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17065315	2006
Loss of naïve cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques. Journal of virology\| PubMed ID: 17093193	2007
The locus encoding an oligomorphic family of MHC-A alleles (Mane-A06/Mamu-A05) is present at high frequency in several macaque species. Immunogenetics\| PubMed ID: 17256149	2007
Although macrophage-tropic simian/human immunodeficiency viruses can exhibit a range of pathogenic phenotypes, a majority of isolates induce no clinical disease in immunocompetent macaques. Journal of virology\| PubMed ID: 17626082	2007
Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques. Journal of virology\| PubMed ID: 17670817	2007
Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response. Journal of virology\| PubMed ID: 18768967	2008
High frequencies of resting CD4+ T cells containing integrated viral DNA are found in rhesus macaques during acute lentivirus infections. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19416840	2009
Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells bu... Journal of virology\| PubMed ID: 19420078	2009
Neutralizing antibody titers conferring protection to macaques from a simian/human immunodeficiency virus challenge using the TZM-bl assay. AIDS research and human retroviruses\| PubMed ID: 20059398	2010
Generation of the pathogenic R5-tropic simian/human immunodeficiency virus SHIVAD8 by serial passaging in rhesus macaques. Journal of virology\| PubMed ID: 20147396	2010
Recombination-mediated changes in coreceptor usage confer an augmented pathogenic phenotype in a nonhuman primate model of HIV-1-induced AIDS. Journal of virology\| PubMed ID: 21813599	2011
The acute HIV infection: implications for intervention, prevention and development of an effective AIDS vaccine. Current opinion in virology\| PubMed ID: 21909345	2011
The simian immunodeficiency virus targets central cell cycle functions through transcriptional repression in vivo. PloS one\| PubMed ID: 22043290	2011
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22123961	2011
Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies. Journal of virology\| PubMed ID: 22647691	2012
Most rhesus macaques infected with the CCR5-tropic SHIV(AD8) generate cross-reactive antibodies that neutralize multiple HIV-1 strains. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23129652	2012
Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization. Science (New York, N.Y.)\| PubMed ID: 23661761	2013
Emergence of gp120 V3 variants confers neutralization resistance in an R5 simian-human immunodeficiency virus-infected macaque elite neutralizer that targets the N332 glycan of the human imm... Journal of virology\| PubMed ID: 23720719	2013
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature\| PubMed ID: 24172896	2013
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. The Journal of experimental medicine\| PubMed ID: 25155019	2014
Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants. The Journal of experimental medicine\| PubMed ID: 25385756	2014
Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nature communications\| PubMed ID: 25858157	2015
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells. PLoS pathogens\| PubMed ID: 25996507	2015
Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection. Science translational medicine\| PubMed ID: 26223303	2015
A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature\| PubMed ID: 27120156	2016
DNA Prime-Boost Vaccine Regimen To Increase Breadth, Magnitude, and Cytotoxicity of the Cellular Immune Responses to Subdominant Gag Epitopes of Simian Immunodeficiency Virus and HIV. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 27733554	2016
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting. PLoS pathogens\| PubMed ID: 28052137	2017
Early antibody therapy can induce long-lasting immunity to SHIV. Nature\| PubMed ID: 28289286	2017
Of Mice, Macaques, and Men: Broadly Neutralizing Antibody Immunotherapy for HIV-1. Cell host & microbe\| PubMed ID: 28799906	2017
Potential of conventional & bispecific broadly neutralizing antibodies for prevention of HIV-1 subtype A, C & D infections. PLoS pathogens\| PubMed ID: 29505593	2018
A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection. Nature medicine\| PubMed ID: 29662199	2018
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature\| PubMed ID: 31142836	2019
Immunotherapy during the acute SHIV infection of macaques confers long-term suppression of viremia. The Journal of experimental medicine\| PubMed ID: 32966579	2021
Concordance of immunological events between intrarectal and intravenous SHIVAD8-EO infection when assessed by Fiebig-equivalent staging. The Journal of clinical investigation\| PubMed ID: 34623326	2021
Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. NPJ vaccines\| PubMed ID: 34697307	2021
Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Science translational medicine\| PubMed ID: 34818054	2021
Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer. Nature communications\| PubMed ID: 35136084	2022