Christopher C.W. Hughes

Department of Molecular Biology and Biochemistry, University of California, Irvine (UCI)

Affiliated withUniversity of California, Irvine (UCI)

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 1	2007
Publication title Cited by 129	2007
Publication title Cited by 165	2007

Other Publications

Article	Year
Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Microvascular research\| PubMed ID: 11866539	2002
B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12244148	2002
Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12244165	2002
Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology. The Journal of biological chemistry\| PubMed ID: 12372818	2002
Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression. Microvascular research\| PubMed ID: 12453432	2002
Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvascular research\| PubMed ID: 12935768	2003
VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 14691306	2003
Of mice and not men: differences between mouse and human immunology. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14978070	2004
Diffusion limits of an in vitro thick prevascularized tissue. Tissue engineering\| PubMed ID: 15738680	2005
Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15774577	2005
Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. International immunology\| PubMed ID: 15908450	2005
Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OC... Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 16241859	2005
HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochemical and biophysical research communications\| PubMed ID: 16782059	2006
Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration. Immunity\| PubMed ID: 17306568	2007
Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue engineering\| PubMed ID: 17518656	2006
The effect of matrix density on the regulation of 3-D capillary morphogenesis. Biophysical journal\| PubMed ID: 17993494	2008
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood\| PubMed ID: 18337563	2008
Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. Circulation research\| PubMed ID: 18369162	2008
Endothelial-stromal interactions in angiogenesis. Current opinion in hematology\| PubMed ID: 18391786	2008
An optimized three-dimensional in vitro model for the analysis of angiogenesis. Methods in enzymology\| PubMed ID: 18772011	2008
The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvascular research\| PubMed ID: 18805433	2009
Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue engineering. Part A\| PubMed ID: 18976155	2009
TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene\| PubMed ID: 19393188	2009
Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of cotransplanted fibroblasts. Tissue engineering. Part A\| PubMed ID: 19737050	2010
Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PloS one\| PubMed ID: 19924227	2009
Estradiol stimulates capillary formation by human endothelial progenitor cells: role of estrogen receptor-{alpha}/{beta}, heme oxygenase 1, and tyrosine kinase. Hypertension\| PubMed ID: 20644008	2010
The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation. Molecular biology of the cell\| PubMed ID: 21865599	2011
Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia. Nature communications\| PubMed ID: 22233626	2012
Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues. Tissue engineering. Part C, Methods\| PubMed ID: 22435776	2012
BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II. Angiogenesis\| PubMed ID: 22622516	2012
Macrophages and angiogenesis: a role for Wnt signaling. Vascular cell\| PubMed ID: 22938389	2012
Full range physiological mass transport control in 3D tissue cultures. Lab on a chip\| PubMed ID: 23090158	2013
Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 23288153	2013
In vitro perfused human capillary networks. Tissue engineering. Part C, Methods\| PubMed ID: 23320912	2013
A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays. Lab on a chip\| PubMed ID: 23723013	2013
Angiogenic sprouting is regulated by endothelial cell expression of Slug. Journal of cell science\| PubMed ID: 24554431	2014
Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis. Tissue engineering. Part A\| PubMed ID: 24593148	2014
Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 24603679	2014
A three-dimensional in vitro model of tumor cell intravasation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 24763498	2014
A role for partial endothelial-mesenchymal transitions in angiogenesis? Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 25425619	2015