Toshiharu Suzuki

Laboratory of Neuroscience, Hokkaido University

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. The Journal of biological chemistry\| PubMed ID: 12972431	2003
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. The Journal of biological chemistry\| PubMed ID: 14970211	2004
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. The Journal of biological chemistry\| PubMed ID: 15037614	2004
Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation. FEBS letters\| PubMed ID: 15178331	2004
Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment. The Journal of biological chemistry\| PubMed ID: 16223726	2005
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 16716194	2006
Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Journal of biochemistry\| PubMed ID: 16788045	2006
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. The Journal of biological chemistry\| PubMed ID: 17032642	2006
[Novel mechanisms in signal transduction and cellular response through neural adaptor proteins]. Seikagaku. The Journal of Japanese Biochemical Society\| PubMed ID: 17131878	2006
Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. The Biochemical journal\| PubMed ID: 17132139	2007
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PloS one\| PubMed ID: 17183681	2006
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. The EMBO journal\| PubMed ID: 17332754	2007
Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-act... Molecular neurodegeneration\| PubMed ID: 18067682	2007
The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm. Experimental cell research\| PubMed ID: 18201694	2008
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells. The Journal of biological chemistry\| PubMed ID: 18468999	2008
Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate. Brain research\| PubMed ID: 18590908	2008
Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. The Journal of biological chemistry\| PubMed ID: 18650433	2008
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme ... The Journal of biological chemistry\| PubMed ID: 18845544	2008
Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. Journal of neurochemistry\| PubMed ID: 19222704	2009
Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of biological chemistry\| PubMed ID: 19407341	2009
X11-like protein deficiency is associated with impaired conflict resolution in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19420255	2009
Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins. Journal of Alzheimer's disease : JAD\| PubMed ID: 19584434	2009
Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein. Journal of neurochemistry\| PubMed ID: 19780898	2009
Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells. The FEBS journal\| PubMed ID: 19796171	2009
Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. The Journal of biological chemistry\| PubMed ID: 19864413	2009
Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells. FEBS letters\| PubMed ID: 20036665	2010
Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. The Journal of biological chemistry\| PubMed ID: 20299451	2010
Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Molecular neurodegeneration\| PubMed ID: 20843325	2010
IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neurons. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 21104742	2011
Expression of sorting nexin 18 (SNX18) is dynamically regulated in developing spinal motor neurons. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 21339182	2011
Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21471357	2011
Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21540330	2011
Alternative processing of Î³-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for Î³-secretase dysfunction. Annals of neurology\| PubMed ID: 21681798	2011
Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like. PloS one\| PubMed ID: 21818298	2011
Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice. PloS one\| PubMed ID: 21829577	2011
Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Molecular neurodegeneration\| PubMed ID: 22067061	2011
A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1. Traffic (Copenhagen, Denmark)\| PubMed ID: 22404616	2012
FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Molecular neurodegeneration\| PubMed ID: 22429478	2012
Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. The Journal of biological chemistry\| PubMed ID: 22511769	2012
Multiple Î³-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular neurodegeneration\| PubMed ID: 22534039	2012
[Alcadein]. Nihon rinsho. Japanese journal of clinical medicine\| PubMed ID: 22787764	2011
Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1. PloS one\| PubMed ID: 22905201	2012
Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease. Molecular neurodegeneration\| PubMed ID: 23034178	2012
Mechanism of intramembrane cleavage of alcadeins by γ-secretase. PloS one\| PubMed ID: 23658629	2013
Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice. PloS one\| PubMed ID: 24098472	2013
Simple and direct assembly of kymographs from movies using KYMOMAKER. Traffic (Copenhagen, Denmark)\| PubMed ID: 24102769	2014
Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 24305499	2014
Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24497505	2014
Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 24614897	2014
Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice. Journal of Alzheimer's disease : JAD\| PubMed ID: 24787913	2014
Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Molecular biology of the cell\| PubMed ID: 25165140	2014
Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP c... The Journal of biological chemistry\| PubMed ID: 25406318	2015
Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice. Brain research\| PubMed ID: 25881896	2015
Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E. FEBS letters\| PubMed ID: 26213366	2015
Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice. Journal of Alzheimer's disease : JAD\| PubMed ID: 26401936	2015
Expression and localization of X11 family proteins in neurons. Brain research\| PubMed ID: 27268412	2016
Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease. Nutritional neuroscience\| PubMed ID: 27329428	2017
Specific Triazine Herbicides Induce Amyloid-β42 Production. Journal of Alzheimer's disease : JAD\| PubMed ID: 27589520	2016
Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron\| PubMed ID: 27608760	2016
Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence. The Journal of biological chemistry\| PubMed ID: 27687728	2016
Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo. Molecular biology of the cell\| PubMed ID: 29093024	2017
Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1. Molecular biology of the cell\| PubMed ID: 29093025	2017
Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. Journal of Alzheimer's disease : JAD\| PubMed ID: 29504531	2018
The cytoplasmic region of the amyloid β-protein precursor (APP) is necessary and sufficient for the enhanced fast velocity of APP transport by kinesin-1. FEBS letters\| PubMed ID: 30055048	2018
Roasted Coffee Reduces β-Amyloid Production by Increasing Proteasomal β-Secretase Degradation in Human Neuroblastoma SH-SY5Y Cells. Molecular nutrition & food research\| PubMed ID: 30144352	2018
X11 and X11-like proteins regulate the level of extrasynaptic glutamate receptors. Journal of neurochemistry\| PubMed ID: 30411795	2019
Novel Notch signaling inhibitor NSI‑1 suppresses nuclear translocation of the Notch intracellular domain. International journal of molecular medicine\| PubMed ID: 31364722	2019
RIMB-1/RIM-Binding Protein and UNC-10/RIM Redundantly Regulate Presynaptic Localization of the Voltage-Gated Calcium Channel in . The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 31530643	2019
Paul Greengard, Ph.D. (1925-2019). Alzheimer's & dementia : the journal of the Alzheimer's Association\| PubMed ID: 31543244	2019
Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.)\| PubMed ID: 31754625	2019
Enhanced amyloid-β generation by γ-secretase complex in DRM microdomains with reduced cholesterol levels. Human molecular genetics\| PubMed ID: 31841137	2020
γ-Secretase Activity Is Associated with Braak Senile Plaque Stages. The American journal of pathology\| PubMed ID: 32201261	2020
Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. Journal of Alzheimer's disease : JAD\| PubMed ID: 32250299	2020
Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of alcadein α-deficient mice. The Journal of biological chemistry\| PubMed ID: 32467230	2020
Cytoplasmic granule formation by FUS-R495X is attributable to arginine methylation in all Gly-rich, RGG1 and RGG2 domains. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 33411976	2021
Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations. Journal of Alzheimer's disease : JAD\| PubMed ID: 33492290	2021
Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model. Scientific reports\| PubMed ID: 33980877	2021
Transcriptional downregulation of FAM3C/ILEI in the Alzheimer's brain. Human molecular genetics\| PubMed ID: 34378027	2021
Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid. Journal of neurochemistry\| PubMed ID: 34379812	2021
γ-Secretase structure and activity are modified by alterations in its membrane localization and ambient environment. Journal of biochemistry\| PubMed ID: 34865063	2022
Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging. Neurobiology of aging\| PubMed ID: 36638682	2023