Thijn R. Brummelkamp

Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute

Affiliated withNetherlands Cancer Institute

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2023

Other Publications

Article	Year
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats. eLife\| PubMed ID: 26698106	2015
A generic strategy for CRISPR-Cas9-mediated gene tagging. Nature communications\| PubMed ID: 26674669	2015
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation. Chemistry & biology\| PubMed ID: 26687144	2015
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. The Journal of biological chemistry\| PubMed ID: 11748239	2002
A system for stable expression of short interfering RNAs in mammalian cells. Science (New York, N.Y.)\| PubMed ID: 11910072	2002
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes & development\| PubMed ID: 11914273	2002
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer cell\| PubMed ID: 12242156	2002
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO reports\| PubMed ID: 12776180	2003
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature\| PubMed ID: 12917690	2003
New tools for functional mammalian cancer genetics. Nature reviews. Cancer\| PubMed ID: 14570045	2003
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. Journal of virology\| PubMed ID: 14963165	2004
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature\| PubMed ID: 15042092	2004
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Molecular cell\| PubMed ID: 15694335	2005
Functional annotation of deubiquitinating enzymes using RNA interference. Methods in enzymology\| PubMed ID: 16275358	2005
A genomic and functional inventory of deubiquitinating enzymes. Cell\| PubMed ID: 16325574	2005
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nature chemical biology\| PubMed ID: 16474381	2006
shRNA libraries and their use in cancer genetics. Nature methods\| PubMed ID: 16929315	2006
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Molecular cancer research : MCR\| PubMed ID: 18723828	2008
Ebola virus entry requires the host-programmed recognition of an intracellular receptor. The EMBO journal\| PubMed ID: 22395071	2012
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. The Journal of biological chemistry\| PubMed ID: 23297415	2013
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Science (New York, N.Y.)\| PubMed ID: 23519211	2013
A reversible gene trap collection empowers haploid genetics in human cells. Nature methods\| PubMed ID: 24161985	2013
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell reports\| PubMed ID: 24685140	2014
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24737893	2014
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science (New York, N.Y.)\| PubMed ID: 24904167	2014
Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Science (New York, N.Y.)\| PubMed ID: 24970085	2014
USP9X downregulation renders breast cancer cells resistant to tamoxifen. Cancer research\| PubMed ID: 25028367	2014
GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. The Journal of biological chemistry\| PubMed ID: 25031321	2014
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. Nature chemical biology\| PubMed ID: 25064833	2014
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line. Genome research\| PubMed ID: 25373145	2014
Emerging intracellular receptors for hemorrhagic fever viruses. Trends in microbiology\| PubMed ID: 26004032	2015
Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo. mBio\| PubMed ID: 26015498	2015
GENE REGULATION. A HUSH for transgene expression. Science (New York, N.Y.)\| PubMed ID: 26113708	2015
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion. mBio\| PubMed ID: 26126854	2015
Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer. Cancer research\| PubMed ID: 26260527	2015
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. eLife\| PubMed ID: 26327695	2015
Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.)\| PubMed ID: 26472760	2015
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO journal\| PubMed ID: 26530471	2015
A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection. Journal of virology\| PubMed ID: 26581979	2016
Enterovirus D68 receptor requirements unveiled by haploid genetics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26787879	2016
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles. mSphere\| PubMed ID: 27303731	2016
PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature\| PubMed ID: 28077878
The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension. Cell\| PubMed ID: 28475897	2017
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature\| PubMed ID: 28562590	2017
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature\| PubMed ID: 28813410	2017
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread. Cell host & microbe\| PubMed ID: 29024641	2017
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell host & microbe\| PubMed ID: 29120745	2017
Vasohibins encode tubulin detyrosinating activity. Science (New York, N.Y.)\| PubMed ID: 29146869
BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised. Cell reports\| PubMed ID: 29425499	2018
KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Cell host & microbe\| PubMed ID: 29681460	2018
Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents. Molecular oncology\| PubMed ID: 29689640	2018
Viral escape from endosomes and host detection at a glance. Journal of cell science\| PubMed ID: 30076240	2018
Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Current biology : CB\| PubMed ID: 30122526	2018
The Tubulin Detyrosination Cycle: Function and Enzymes. Trends in cell biology\| PubMed ID: 30213517	2019
Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma. Cancer research\| PubMed ID: 30213788	2018
LZTR1 is a regulator of RAS ubiquitination and signaling. Science (New York, N.Y.)\| PubMed ID: 30442766	2018
Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature\| PubMed ID: 30464266	2018
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. Nature communications\| PubMed ID: 30626869	2019
SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. PloS one\| PubMed ID: 30753225	2019
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nature medicine\| PubMed ID: 30833751	2019
A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection. Journal of virology\| PubMed ID: 30996093	2019
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nature structural & molecular biology\| PubMed ID: 31270470
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Nature communications\| PubMed ID: 32111832	2020
regulates the action of nitrogen-containing bisphosphonates on bone. Science translational medicine\| PubMed ID: 32434850	2020
Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway. Science signaling\| PubMed ID: 32934076	2020
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. Immunity\| PubMed ID: 33271119	2021
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33443154	2021
A Mediator-cohesin axis controls heterochromatin domain formation. Nature communications\| PubMed ID: 35136067	2022
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science (New York, N.Y.)\| PubMed ID: 35482892	2022
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism. Nature structural & molecular biology\| PubMed ID: 35710836	2022
Actin maturation requires the ACTMAP/C19orf54 protease. Science (New York, N.Y.)\| PubMed ID: 36173861	2022

Article	Year
Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats. eLife\| PubMed ID: 26698106	2015
A generic strategy for CRISPR-Cas9-mediated gene tagging. Nature communications\| PubMed ID: 26674669	2015
Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation. Chemistry & biology\| PubMed ID: 26687144	2015
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. The Journal of biological chemistry\| PubMed ID: 11748239	2002
A system for stable expression of short interfering RNAs in mammalian cells. Science (New York, N.Y.)\| PubMed ID: 11910072	2002
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes & development\| PubMed ID: 11914273	2002
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer cell\| PubMed ID: 12242156	2002
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO reports\| PubMed ID: 12776180	2003
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature\| PubMed ID: 12917690	2003
New tools for functional mammalian cancer genetics. Nature reviews. Cancer\| PubMed ID: 14570045	2003
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. Journal of virology\| PubMed ID: 14963165	2004
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature\| PubMed ID: 15042092	2004
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Molecular cell\| PubMed ID: 15694335	2005
Functional annotation of deubiquitinating enzymes using RNA interference. Methods in enzymology\| PubMed ID: 16275358	2005
A genomic and functional inventory of deubiquitinating enzymes. Cell\| PubMed ID: 16325574	2005
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nature chemical biology\| PubMed ID: 16474381	2006
shRNA libraries and their use in cancer genetics. Nature methods\| PubMed ID: 16929315	2006
Suppression of the p53-dependent replicative senescence response by lysophosphatidic acid signaling. Molecular cancer research : MCR\| PubMed ID: 18723828	2008
Ebola virus entry requires the host-programmed recognition of an intracellular receptor. The EMBO journal\| PubMed ID: 22395071	2012
Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants. The Journal of biological chemistry\| PubMed ID: 23297415	2013
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Science (New York, N.Y.)\| PubMed ID: 23519211	2013
A reversible gene trap collection empowers haploid genetics in human cells. Nature methods\| PubMed ID: 24161985	2013
Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell reports\| PubMed ID: 24685140	2014
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24737893	2014
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science (New York, N.Y.)\| PubMed ID: 24904167	2014
Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Science (New York, N.Y.)\| PubMed ID: 24970085	2014
USP9X downregulation renders breast cancer cells resistant to tamoxifen. Cancer research\| PubMed ID: 25028367	2014
GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. The Journal of biological chemistry\| PubMed ID: 25031321	2014
The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity. Nature chemical biology\| PubMed ID: 25064833	2014
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line. Genome research\| PubMed ID: 25373145	2014
Emerging intracellular receptors for hemorrhagic fever viruses. Trends in microbiology\| PubMed ID: 26004032	2015
Niemann-pick C1 is essential for ebolavirus replication and pathogenesis in vivo. mBio\| PubMed ID: 26015498	2015
GENE REGULATION. A HUSH for transgene expression. Science (New York, N.Y.)\| PubMed ID: 26113708	2015
Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion. mBio\| PubMed ID: 26126854	2015
Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer. Cancer research\| PubMed ID: 26260527	2015
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. eLife\| PubMed ID: 26327695	2015
Gene essentiality and synthetic lethality in haploid human cells. Science (New York, N.Y.)\| PubMed ID: 26472760	2015
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. The EMBO journal\| PubMed ID: 26530471	2015
A Haploid Genetic Screen Identifies Heparan Sulfate Proteoglycans Supporting Rift Valley Fever Virus Infection. Journal of virology\| PubMed ID: 26581979	2016
Enterovirus D68 receptor requirements unveiled by haploid genetics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26787879	2016
A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles. mSphere\| PubMed ID: 27303731	2016
PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature\| PubMed ID: 28077878
The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension. Cell\| PubMed ID: 28475897	2017
Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling. Nature\| PubMed ID: 28562590	2017
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature\| PubMed ID: 28813410	2017
Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread. Cell host & microbe\| PubMed ID: 29024641	2017
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell host & microbe\| PubMed ID: 29120745	2017
Vasohibins encode tubulin detyrosinating activity. Science (New York, N.Y.)\| PubMed ID: 29146869
BUB1 Is Essential for the Viability of Human Cells in which the Spindle Assembly Checkpoint Is Compromised. Cell reports\| PubMed ID: 29425499	2018
KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Cell host & microbe\| PubMed ID: 29681460	2018
Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents. Molecular oncology\| PubMed ID: 29689640	2018
Viral escape from endosomes and host detection at a glance. Journal of cell science\| PubMed ID: 30076240	2018
Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores. Current biology : CB\| PubMed ID: 30122526	2018
The Tubulin Detyrosination Cycle: Function and Enzymes. Trends in cell biology\| PubMed ID: 30213517	2019
Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma. Cancer research\| PubMed ID: 30213788	2018
LZTR1 is a regulator of RAS ubiquitination and signaling. Science (New York, N.Y.)\| PubMed ID: 30442766	2018
Protocadherin-1 is essential for cell entry by New World hantaviruses. Nature\| PubMed ID: 30464266	2018
BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity. Nature communications\| PubMed ID: 30626869	2019
SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing. PloS one\| PubMed ID: 30753225	2019
Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nature medicine\| PubMed ID: 30833751	2019
A Genome-Wide Haploid Genetic Screen Identifies Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator TMED10 as Factors Supporting Vaccinia Virus Infection. Journal of virology\| PubMed ID: 30996093	2019
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nature structural & molecular biology\| PubMed ID: 31270470
Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism. Nature communications\| PubMed ID: 32111832	2020
regulates the action of nitrogen-containing bisphosphonates on bone. Science translational medicine\| PubMed ID: 32434850	2020
Quantitative genetic screening reveals a Ragulator-FLCN feedback loop that regulates the mTORC1 pathway. Science signaling\| PubMed ID: 32934076	2020
The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses. Immunity\| PubMed ID: 33271119	2021
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33443154	2021
A Mediator-cohesin axis controls heterochromatin domain formation. Nature communications\| PubMed ID: 35136067	2022
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science (New York, N.Y.)\| PubMed ID: 35482892	2022
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism. Nature structural & molecular biology\| PubMed ID: 35710836	2022
Actin maturation requires the ACTMAP/C19orf54 protease. Science (New York, N.Y.)\| PubMed ID: 36173861	2022