Dirk Grimm

Cluster of Excellence CellNetworks, Heidelberg University

Affiliated withHeidelberg University University of Heidelberg Cluster of Excellence CellNetworks

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 35	2012
Publication title Cited by 2	2022

Other Publications

Article	Year
Primary human cells differ in their susceptibility to rAAV-2-mediated gene transfer and duration of reporter gene expression. Journal of virological methods\| PubMed ID: 12270659	2002
Production methods for gene transfer vectors based on adeno-associated virus serotypes. Methods (San Diego, Calif.)\| PubMed ID: 12413413	2002
Helper virus-free, optically controllable, and two-plasmid-based production of adeno-associated virus vectors of serotypes 1 to 6. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12788658	2003
Preclinical in vivo evaluation of pseudotyped adeno-associated virus vectors for liver gene therapy. Blood\| PubMed ID: 12791653	2003
Adeno-associated virus vectors for short hairpin RNA expression. Methods in enzymology\| PubMed ID: 15644194	2005
Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo. Human gene therapy\| PubMed ID: 15916481	2005
Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. Journal of virology\| PubMed ID: 16352567	2006
Improved cardiac gene transfer by transcriptional and transductional targeting of adeno-associated viral vectors. Cardiovascular research\| PubMed ID: 16448634	2006
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature\| PubMed ID: 16724069	2006
The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. Journal of virology\| PubMed ID: 16973587	2006
A two-hybrid screen identifies cathepsins B and L as uncoating factors for adeno-associated virus 2 and 8. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17235311	2007
Combinatorial RNAi: a winning strategy for the race against evolving targets? Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 17311009	2007
Rapid and stable knockdown of an endogenous gene in retinal pigment epithelium. Human gene therapy\| PubMed ID: 17892416	2007
RNAi and gene therapy: a mutual attraction. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program\| PubMed ID: 18024667	2007
Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? The Journal of clinical investigation\| PubMed ID: 18060021	2007
Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells. Hepatology (Baltimore, Md.)\| PubMed ID: 18220289	2008
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses. Journal of virology\| PubMed ID: 18400866	2008
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia. The Journal of biological chemistry\| PubMed ID: 18524776	2008
Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18665161	2008
Small silencing RNAs: state-of-the-art. Advanced drug delivery reviews\| PubMed ID: 19427885	2009
Low-level shRNA cytotoxicity can contribute to MYC-induced hepatocellular carcinoma in adult mice. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 19844192	2010
Six RNA viruses and forty-one hosts: viral small RNAs and modulation of small RNA repertoires in vertebrate and invertebrate systems. PLoS pathogens\| PubMed ID: 20169186	2010
Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. The Journal of clinical investigation\| PubMed ID: 20697157	2010
Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21576459	2011
Cellular RNA interference mechanisms. Preface. Progress in molecular biology and translational science\| PubMed ID: 21846566	2011
When cellular networks run out of control: global dysregulation of the RNAi machinery in human pathology and therapy. Progress in molecular biology and translational science\| PubMed ID: 21846572	2011
To go, or not to go, that is the question - six personal reflections on how geographic mobility may affect your career and life. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 21858845	2011
The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression. Silence\| PubMed ID: 22029761	2011
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. The Journal of clinical investigation\| PubMed ID: 22105172	2011
Expression determinants of mammalian argonaute proteins in mediating gene silencing. Nucleic acids research\| PubMed ID: 22210886	2011
AAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasites. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 25189739	2014
Zinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining. Genome biology\| PubMed ID: 26573820	2015
Death receptor-based enrichment of Cas9-expressing cells. BMC biotechnology\| PubMed ID: 26883910	2016
Blocking sense-strand activity improves potency, safety and specificity of anti-hepatitis B virus short hairpin RNA. EMBO molecular medicine\| PubMed ID: 27473329	2016
TALEN/CRISPR-mediated engineering of a promoterless anti-viral RNAi hairpin into an endogenous miRNA locus. Nucleic acids research\| PubMed ID: 27614072	2017
Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28137845	2017
Next-generation AAV vectors for clinical use: an ever-accelerating race. Virus genes\| PubMed ID: 28762205	2017
Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells. Journal of virology\| PubMed ID: 28768875	2017
Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution. Human gene therapy\| PubMed ID: 28835125	2017
Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology. Biotechnology journal\| PubMed ID: 29316283	2018
Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1. Frontiers in molecular neuroscience\| PubMed ID: 29379413	2017
High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious. Journal of molecular biology\| PubMed ID: 29782834	2018
Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids. Human gene therapy\| PubMed ID: 29978729	2019
AAVvector-mediated in vivo reprogramming into pluripotency. Nature communications\| PubMed ID: 29985406	2018
Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9. Nature methods\| PubMed ID: 30377362	2018
A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses. ACS synthetic biology\| PubMed ID: 30513195	2019
Novel Chimeric Gene Therapy Vectors Based on Adeno-Associated Virus and Four Different Mammalian Bocaviruses. Molecular therapy. Methods & clinical development\| PubMed ID: 30766894	2019
Rapid and Simple Screening of CRISPR Guide RNAs (gRNAs) in Cultured Cells Using Adeno-Associated Viral (AAV) Vectors. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30912043	2019
Cell-specific CRISPR-Cas9 activation by microRNA-dependent expression of anti-CRISPR proteins. Nucleic acids research\| PubMed ID: 30982889	2019
Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome. The Pediatric infectious disease journal\| PubMed ID: 31033910	2019
Distinct transduction of muscle tissue in mice after systemic delivery of AAVpo1 vectors. Gene therapy\| PubMed ID: 31624368	2020
Ex Vivo/In vivo Gene Editing in Hepatocytes Using "All-in-One" CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template. iScience\| PubMed ID: 31887661	2020
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 32105604	2020
Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity. Journal of virology\| PubMed ID: 32213611	2020
Computational design of anti-CRISPR proteins with improved inhibition potency. Nature chemical biology\| PubMed ID: 32284602	2020
Lab-Scale Production of Recombinant Adeno-Associated Viruses (AAV) for Expression of Optogenetic Elements. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32651911	2020
Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors. Biotechnology journal\| PubMed ID: 32975881	2021
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants. Nature communications\| PubMed ID: 33116134	2020
Breaking the sound barrier: Towards next-generation AAV vectors for gene therapy of hearing disorders. Hearing research\| PubMed ID: 33268240	2022
Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein. Nucleic acids research\| PubMed ID: 33330940	2021
'Hit and run' therapy averts macular degeneration. Nature biomedical engineering\| PubMed ID: 33580229	2021
A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. Molecular therapy. Methods & clinical development\| PubMed ID: 33665228	2021
Characterization of the GBoV1 Capsid and Its Antibody Interactions. Viruses\| PubMed ID: 33672786	2021
Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 33831556	2021
A Versatile In Vivo System to Study Myc in Cell Reprogramming. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34019296	2021
Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing. Signal transduction and targeted therapy\| PubMed ID: 34035211	2021
The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell reports\| PubMed ID: 34407407	2021
Neutralizing Antibody Evasion and Transduction with Purified Extracellular Vesicle-Enveloped Adeno-Associated Virus Vectors. Human gene therapy\| PubMed ID: 34445894	2021
An RNA Interference/Adeno-Associated Virus Vector-Based Combinatorial Gene Therapy Approach Against Hepatitis E Virus. Hepatology communications\| PubMed ID: 34719133	2022
Lentiviral and adeno-associated vectors efficiently transduce mouse T lymphocytes when targeted to murine CD8. Molecular therapy. Methods & clinical development\| PubMed ID: 34729380	2021
Adeno-Associated Viruses (AAV) and Host Immunity - A Race Between the Hare and the Hedgehog. Frontiers in immunology\| PubMed ID: 34777364	2021
Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models. Nature communications\| PubMed ID: 34819506	2021
Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 35038579	2022
Natural killer cells act as an extrinsic barrier for in vivo reprogramming. Development (Cambridge, England)\| PubMed ID: 35420133	2022
Right on target: The next class of efficient, safe, and specific RNAi triggers. Molecular therapy. Nucleic acids\| PubMed ID: 35505965	2022
Identification of adeno-associated virus variants for gene transfer into human neural cell types by parallel capsid screening. Scientific reports\| PubMed ID: 35589936	2022
Intranasal application of adeno-associated viruses: a systematic review. Translational research : the journal of laboratory and clinical medicine\| PubMed ID: 35597541	2022
Fantastic AAV Gene Therapy Vectors and How to Find Them-Random Diversification, Rational Design and Machine Learning. Pathogens (Basel, Switzerland)\| PubMed ID: 35890005	2022
Boosters for adeno-associated virus vector (AAV) (r)evolution. Cytotherapy\| PubMed ID: 35999132	2022
In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice. Nature communications\| PubMed ID: 36064805	2022
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders. Science advances\| PubMed ID: 36129972	2022
Determination of AAV properties by single amino acids: Go(o)d is in the details. Molecular therapy. Methods & clinical development\| PubMed ID: 36212908	2022