Joan S. Brugge

Department of Cell Biology, Harvard Medical School

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 47	2012

Other Publications

Article	Year
Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. The Journal of cell biology\| PubMed ID: 11940607	2002
Sensing the environment: a historical perspective on integrin signal transduction. Nature cell biology\| PubMed ID: 11944041	2002
Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog. Biochemical and biophysical research communications\| PubMed ID: 12051709	2002
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell\| PubMed ID: 12372298	2002
Overview of the Alliance for Cellular Signaling. Nature\| PubMed ID: 12478301	2002
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods (San Diego, Calif.)\| PubMed ID: 12798140	2003
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nature cell biology\| PubMed ID: 12844146	2003
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell\| PubMed ID: 12859901	2003
Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. The Journal of cell biology\| PubMed ID: 14568991	2003
Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14593208	2003
Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14739340	2004
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14993595	2004
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene\| PubMed ID: 15064711	2004
ErbB2 and TGF-beta: a cooperative role in mammary tumor progression? Cell cycle (Georgetown, Tex.)\| PubMed ID: 15107620	2004
Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. The Journal of cell biology\| PubMed ID: 15117969	2004
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. The Journal of cell biology\| PubMed ID: 15249579	2004
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Molecular and cellular biology\| PubMed ID: 15367678	2004
Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. Journal of mammary gland biology and neoplasia\| PubMed ID: 15838601	2004
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron\| PubMed ID: 15848800	2005
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Molecular and cellular biology\| PubMed ID: 15899862	2005
G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Molecular and cellular biology\| PubMed ID: 15923641	2005
Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene\| PubMed ID: 16007176	2005
Modelling glandular epithelial cancers in three-dimensional cultures. Nature reviews. Cancer\| PubMed ID: 16148884	2005
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer research\| PubMed ID: 16322248	2005
Novel role for PDEF in epithelial cell migration and invasion. Cancer research\| PubMed ID: 16357167	2005
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. The Journal of cell biology\| PubMed ID: 16365168	2005
Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. Journal of proteome research\| PubMed ID: 16512675	2006
Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity\| PubMed ID: 16546099	2006
An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell communication and signaling : CCS\| PubMed ID: 16709244	2006
p63 regulates an adhesion programme and cell survival in epithelial cells. Nature cell biology\| PubMed ID: 16715076	2006
Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16894141	2006
SePARating polarity and proliferation in ErbB2 oncogenesis. Nature cell biology\| PubMed ID: 17077856	2006
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Developmental cell\| PubMed ID: 17276340	2007
p63, cell adhesion and survival. Cell cycle (Georgetown, Tex.)\| PubMed ID: 17297292	2007
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360431	2007
Common effector processing mediates cell-specific responses to stimuli. Nature\| PubMed ID: 17637676	2007
Tensins: a new switch in cell migration. Developmental cell\| PubMed ID: 17765673	2007
Engineering tumors with 3D scaffolds. Nature methods\| PubMed ID: 17767164	2007
A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell\| PubMed ID: 18045538	2007
IL-6 involvement in epithelial cancers. The Journal of clinical investigation\| PubMed ID: 18060028	2007
Circulating colony stimulating factor-1 and breast cancer risk. Cancer research\| PubMed ID: 18172291	2008
Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18196964	2008
[Entosis, a cell death process related to cell cannibalism between tumor cells]. MÃ©decine sciences : M/S\| PubMed ID: 18334170	2008
Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Current biology : CB\| PubMed ID: 18394891	2008
The cell biology of cell-in-cell structures. Nature reviews. Molecular cell biology\| PubMed ID: 18784728	2008
Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nature cell biology\| PubMed ID: 19160483	2008
Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer research\| PubMed ID: 19258500	2009
YB-1 translational control of epithelial-mesenchyme transition. Cancer cell\| PubMed ID: 19411064	2009
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature\| PubMed ID: 19693011	2009
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nature cell biology\| PubMed ID: 19935651	2009
Transcriptional regulation of metastatic [Id]entity by KLF17. Genome biology\| PubMed ID: 19951400	2009
A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer cell\| PubMed ID: 19962663	2009
Tumor self-seeding: bidirectional flow of tumor cells. Cell\| PubMed ID: 20064369	2009
Mutant p53 drives invasion by promoting integrin recycling. Cell\| PubMed ID: 20064378	2009
MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20133671	2010
Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20194747	2010
Identifying single-cell molecular programs by stochastic profiling. Nature methods\| PubMed ID: 20228812	2010
Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Molecular biology of the cell\| PubMed ID: 20462959	2010
PTK6 regulates IGF-1-induced anchorage-independent survival. PloS one\| PubMed ID: 20668531	2010
ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. The Journal of biological chemistry\| PubMed ID: 20956544	2011
Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. PloS one\| PubMed ID: 21049007	2010
Mechanistic biology in the next quarter century. Molecular biology of the cell\| PubMed ID: 21079017	2010
A non-genetic route to aneuploidy in human cancers. Nature cell biology\| PubMed ID: 21336303	2011
Uncovering a tumor suppressor for triple-negative breast cancers. Cell\| PubMed ID: 21376226	2011
Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes & development\| PubMed ID: 21406550	2011
The myosin-II-responsive focal adhesion proteome: a tour de force? Nature cell biology\| PubMed ID: 21423174	2011
The myosin-II-responsive focal adhesion proteome: a tour de force? Nature cell biology\| PubMed ID: 21460805	2011
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature genetics\| PubMed ID: 21804546	2011
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes & development\| PubMed ID: 21852536	2011
Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21873240	2011
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer discovery\| PubMed ID: 22303516	2011
Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature\| PubMed ID: 22318515	2012