Yu-Hua Tseng

Section on Integrative Physiology and Metabolism, Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2023

Other Publications

Article	Year
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10611312	1999
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. Molecular and cellular biology\| PubMed ID: 11784871	2002
Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin. The Journal of biological chemistry\| PubMed ID: 12082100	2002
Differential roles of insulin receptor substrates in brown adipocyte differentiation. Molecular and cellular biology\| PubMed ID: 14966273	2004
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15240880	2004
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nature cell biology\| PubMed ID: 15895078	2005
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell\| PubMed ID: 16096055	2005
Developmental origin of fat: tracking obesity to its source. Cell\| PubMed ID: 17956727	2007
Rad GTPase deficiency leads to cardiac hypertrophy. Circulation\| PubMed ID: 18056528	2007
Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18268350	2008
Substance P as a novel anti-obesity target. Gastroenterology\| PubMed ID: 18325388	2008
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature\| PubMed ID: 18719589	2008
Identification and importance of brown adipose tissue in adult humans. The New England journal of medicine\| PubMed ID: 19357406	2009
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes\| PubMed ID: 19502417	2009
Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine & growth factor reviews\| PubMed ID: 19896888	2009
Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription. The Journal of biological chemistry\| PubMed ID: 20360006	2010
Cellular bioenergetics as a target for obesity therapy. Nature reviews. Drug discovery\| PubMed ID: 20514071	2010
Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Molecular and cellular biology\| PubMed ID: 20584981	2010
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21173238	2011
Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity. PloS one\| PubMed ID: 21311592	2011
Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology\| PubMed ID: 21862615	2011
Necdin controls proliferation of white adipocyte progenitor cells. PloS one\| PubMed ID: 22292082	2012
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22331196	2012
Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes\| PubMed ID: 22596050	2012
Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxidants & redox signaling\| PubMed ID: 22938691	2013
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. The Journal of clinical investigation\| PubMed ID: 23221344	2013
p62 links β-adrenergic input to mitochondrial function and thermogenesis. The Journal of clinical investigation\| PubMed ID: 23257354	2013
Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nature medicine\| PubMed ID: 23291629	2013
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature\| PubMed ID: 23485971	2013
Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 23538494	2013
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nature medicine\| PubMed ID: 23603815	2013
Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential. Adipocyte\| PubMed ID: 23700507	2012
Brown adipose tissue: development, metabolism and beyond. The Biochemical journal\| PubMed ID: 23805974	2013
Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 24071505	2013
Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Annals of the New York Academy of Sciences\| PubMed ID: 24111913	2013
Brown fat fuel utilization and thermogenesis. Trends in endocrinology and metabolism: TEM\| PubMed ID: 24389130	2014
Glial cell line-derived neurotrophic factor protects against high-fat diet-induced obesity. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 24458024	2014
Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell\| PubMed ID: 24485453	2014
Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem cell reports\| PubMed ID: 24678452	2014
IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell\| PubMed ID: 24995979	2014
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science translational medicine\| PubMed ID: 25080478	2014
Unwiring the transcriptional heat circuit. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25261553	2014
A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes\| PubMed ID: 25605808	2015
Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development. Endocrinology\| PubMed ID: 25625589	2015
Genetic and functional characterization of clonally derived adult human brown adipocytes. Nature medicine\| PubMed ID: 25774848	2015
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nature medicine\| PubMed ID: 26076036	2015
Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Scientific reports\| PubMed ID: 26269357	2015
MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network. EMBO reports\| PubMed ID: 26303948	2015
The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation. Genes & diseases\| PubMed ID: 26491708	2015
3D brown adipogenesis to create "Brown-Fat-in-Microstrands". Biomaterials\| PubMed ID: 26496384	2016
Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochemical and biophysical research communications\| PubMed ID: 26801556	2016
Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia\| PubMed ID: 27209464	2016
Monoacylglycerol Analysis Using MS/MS(ALL) Quadruple Time of Flight Mass Spectrometry. Metabolites\| PubMed ID: 27548241	2016
Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals. Cell metabolism\| PubMed ID: 27626200	2016
Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28244042	2017
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nature medicine\| PubMed ID: 28346411	2017
Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Scientific reports\| PubMed ID: 28469146	2017
Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI insight\| PubMed ID: 28570265	2017
Ca-associated triphasic pH changes in mitochondria during brown adipocyte activation. Molecular metabolism\| PubMed ID: 28752044	2017
Deciphering adipose tissue heterogeneity. Annals of the New York Academy of Sciences\| PubMed ID: 28763833	2018
NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program. Nature cell biology\| PubMed ID: 28812581	2017
MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure. Frontiers in endocrinology\| PubMed ID: 28878735	2017
Reestablishment of Energy Balance in a Male Mouse Model With POMC Neuron Deletion of BMPR1A. Endocrinology\| PubMed ID: 29040444	2017
Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. Cell reports\| PubMed ID: 29241534	2017
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nature medicine\| PubMed ID: 29400713	2018
Adapted MS/MS Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species. Lipids\| PubMed ID: 29488636	2018
12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell metabolism\| PubMed ID: 29719226	2018
Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell metabolism\| PubMed ID: 29861389	2018
RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 29952110	2018
Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell reports\| PubMed ID: 30021173	2018
Shades of brown: an introduction for the special focus issue of Adipocyte on "brown and beige/brite adipocytes". Adipocyte\| PubMed ID: 30168365	2016
Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Molecular metabolism\| PubMed ID: 30316806	2018
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nature metabolism\| PubMed ID: 31032475	2019
ComBATing aging-does increased brown adipose tissue activity confer longevity? GeroScience\| PubMed ID: 31230192	2019
Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue. EMBO reports\| PubMed ID: 31264358	2019
12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell metabolism\| PubMed ID: 31353262	2019
Lipokines and Thermogenesis. Endocrinology\| PubMed ID: 31504387	2019
Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes. PLoS biology\| PubMed ID: 32040503	2020
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nature communications\| PubMed ID: 32184391	2020
Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 32219757	2020
Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. The Journal of clinical investigation\| PubMed ID: 32250344	2020
Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nature communications\| PubMed ID: 32355218	2020
The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nature communications\| PubMed ID: 32457326	2020
Commentary on: "The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans". The Journal of clinical endocrinology and metabolism\| PubMed ID: 32559764	2020
Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity. GeroScience\| PubMed ID: 32632845	2020
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells. Cell\| PubMed ID: 32679029	2020
The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue. Diabetes\| PubMed ID: 32690661	2020
The Link between Stress and IL-6 Is Heating Up. Cell metabolism\| PubMed ID: 32755607	2020
Lipidomics of brown and white adipose tissue: Implications for energy metabolism. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 32763428	2020
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Science translational medicine\| PubMed ID: 32848096	2020
Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity. The Journal of clinical endocrinology and metabolism\| PubMed ID: 33135728	2021
The involvement of neuroimmune cells in adipose innervation. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 33297933	2020
Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature. Cell metabolism\| PubMed ID: 33406404	2021
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Cell reports\| PubMed ID: 33440156	2021
Vascular smooth muscle-derived Trpv1 progenitors are a source of cold-induced thermogenic adipocytes. Nature metabolism\| PubMed ID: 33846638	2021
Defining the lineage of thermogenic perivascular adipose tissue. Nature metabolism\| PubMed ID: 33846639	2021
Challenges in tackling energy expenditure as obesity therapy: From preclinical models to clinical application. Molecular metabolism\| PubMed ID: 33878401	2021
Cold-induction of afadin in brown fat supports its thermogenic capacity. Scientific reports\| PubMed ID: 33963248	2021
Narrating the story ARC of adipose tissue aging. Developmental cell\| PubMed ID: 34004148	2021
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis. JCI insight\| PubMed ID: 34100382	2021
N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes. Biochimica et biophysica acta. Molecular and cell biology of lipids\| PubMed ID: 34487913	2021
The evolving view of thermogenic adipocytes - ontogeny, niche and function. Nature reviews. Endocrinology\| PubMed ID: 34625737	2021
Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages. Genome research\| PubMed ID: 35042723	2022
Signaling Lipidomic Analysis of Thermogenic Adipocytes. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 35167102	2022
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell metabolism\| PubMed ID: 35305295	2022
Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem cells (Dayton, Ohio)\| PubMed ID: 35511869	2022
Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice. International journal of molecular sciences\| PubMed ID: 35628137	2022
Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis. Circulation research\| PubMed ID: 35642564	2022
Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure. Frontiers in bioengineering and biotechnology\| PubMed ID: 35646839	2022
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. Nature metabolism\| PubMed ID: 35760872	2022
Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nature communications\| PubMed ID: 36241662	2022
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell\| PubMed ID: 36334589	2022
ADRA1A-Gα signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nature metabolism\| PubMed ID: 36344764	2022
Adipose tissue in communication: within and without. Nature reviews. Endocrinology\| PubMed ID: 36526875	2023
Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. Nature metabolism\| PubMed ID: 36536132	2022