estrogen-like-effect-of-bazi-bushen-capsule-in-ovariectomized-rats

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

This study aims to show the estrogen-like effect of Bazi Bushen capsule (BZBS), a Chinese herbal compound, in ovariectomized mice. Female Sprague-Dawley ...

Hebei Medical University

National Key Laboratory of Collateral Disease Research and Innovative Chinese Medicine

State Administration of Traditional Chinese Medicine

Heart failure with preserved ejection fraction (HFpEF) is a common public health problem associated with increased morbidity and long-term mortality. However, effective treatment for HFpEF was not discovered yet. In the present study, we aimed to decipher the effects of Periplocin on DOCA-induced heart failure rats and explore the possible underlying mechanisms. We demonstrated that Periplocin could significantly attenuate cardiac structural remodeling and improve cardiac diastolic function. Of note, Periplocin significantly inhibited the recruitment of inflammatory and immune cells and decreased the expression of serum inflammatory cytokines. Meanwhile, Periplocin had the effect of cardiac glycosides to improve cardiomyocyte contractility and calcium transient amplitude. These findings indicate that Periplocin might be a potential medicine to treat HFpEF in patients.

Periplocin Alleviates Cardiac Remodeling in DOCA-Salt-Induced Heart Failure Rats.

The aim of our study was to investigate the mechanism by which the Chinese compound Shensong Yangxin Capsule (SSYX) reduces susceptibility to arrhythmia in db/db mice.

Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction.

Article	Year
Periplocin Alleviates Cardiac Remodeling in DOCA-Salt-Induced Heart Failure Rats. Journal of cardiovascular translational research\| PubMed ID: 35616880	2023
Shensong Yangxin Capsule Reduces the Susceptibility of Arrhythmia in db/db Mice via Inhibiting the Inflammatory Response Induced by Endothelium Dysfunction. Drug design, development and therapy\| PubMed ID: 36776448	2023

Dandong Wang

Biography

JoVE Journal Publications

Other Publications