Christiaan Leeuwenburgh

Department of Physiology and Aging, University of Florida

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15271790	2004
Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats. Experimental gerontology\| PubMed ID: 15664730	2005
Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 15665035	2005
Lifelong aspirin supplementation as a means to extending life span. Rejuvenation research\| PubMed ID: 15671726	2004
Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mechanisms of ageing and development\| PubMed ID: 15888333	2005
WITHDRAWN: Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors. Neurobiology of aging\| PubMed ID: 16198026	2005
A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biological chemistry\| PubMed ID: 16497170	2006
C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity. Metabolism: clinical and experimental\| PubMed ID: 16546475	2006
Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 16567369	2006
Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxidants & redox signaling\| PubMed ID: 16677097	2006
Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise. Antioxidants & redox signaling\| PubMed ID: 16677098	2006
Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders. Antioxidants & redox signaling\| PubMed ID: 16677104	2006
Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study. The American journal of clinical nutrition\| PubMed ID: 16685058	2006
Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study. Archives of internal medicine\| PubMed ID: 16864759	2006
Skeletal muscle apoptosis, sarcopenia and frailty at old age. Experimental gerontology\| PubMed ID: 17052879	2006
Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice. Experimental gerontology\| PubMed ID: 17118599	2007
Cardiac mitochondrial bioenergetics, oxidative stress, and aging. American journal of physiology. Cell physiology\| PubMed ID: 17344313	2007
Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla... Experimental gerontology\| PubMed ID: 17540525	2007
Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation research\| PubMed ID: 17665967	2007
Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxi... Journal of chromatography. A\| PubMed ID: 17765254	2007
Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiology of aging\| PubMed ID: 17976863	2009
The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging. Experimental gerontology\| PubMed ID: 17997255	2008
Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 18003794	2008
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free radical biology & medicine\| PubMed ID: 18191752	2008
Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat. Experimental gerontology\| PubMed ID: 18313875	2008
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Experimental gerontology\| PubMed ID: 18395385	2008
A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PloS one\| PubMed ID: 18523577	2008
Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mechanisms of ageing and development\| PubMed ID: 18579179	2008
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging cell\| PubMed ID: 18631321	2008
Iron accumulation with age, oxidative stress and functional decline. PloS one\| PubMed ID: 18682742	2008
Molecular inflammation: underpinnings of aging and age-related diseases. Ageing research reviews\| PubMed ID: 18692159	2009
Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation research\| PubMed ID: 18729811	2008
Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults. Mechanisms of ageing and development\| PubMed ID: 18762207	2008
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutrition reviews\| PubMed ID: 18826454	2008
Radical scavenging and reducing ability of tilapia (Oreochromis niloticus) protein hydrolysates. Journal of agricultural and food chemistry\| PubMed ID: 18828605	2008
Mitochondrial iron accumulation with age and functional consequences. Aging cell\| PubMed ID: 18843794	2008
Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging cell\| PubMed ID: 19239416	2009
Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic acids research\| PubMed ID: 19244310	2009
Changes in lipid distribution during aging and its modulation by calorie restriction. Age (Dordrecht, Netherlands)\| PubMed ID: 19277901	2009
Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction. BioFactors (Oxford, England)\| PubMed ID: 19319843	2009
Hydrogen sulfide induces oxidative damage to RNA and DNA in a sulfide-tolerant marine invertebrate. Physiological and biochemical zoology : PBZ\| PubMed ID: 19327040	2010
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mechanisms of ageing and development\| PubMed ID: 19396981	2009
Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 19420296	2009
Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mechanisms of ageing and development\| PubMed ID: 19428447	2009
Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochimica et biophysica acta\| PubMed ID: 19450666	2010
Revealing system-level correlations between aging and calorie restriction using a mouse transcriptome. Age (Dordrecht, Netherlands)\| PubMed ID: 19590981	2010
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19901338	2009
Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Experimental gerontology\| PubMed ID: 19903516	2010
Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives. Clinics in geriatric medicine\| PubMed ID: 19944269	2009
Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 20045871	2010
Myeloperoxidase levels and mortality in frail community-living elderly individuals. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 20064836	2010
Biochemical indices as correlates of recent growth in juvenile green turtles (Chelonia mydas). Journal of experimental marine biology and ecology\| PubMed ID: 20161581	2009
Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. TheScientificWorldJournal\| PubMed ID: 20191247	2010
Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation research\| PubMed ID: 20230280	2010
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mechanisms of ageing and development\| PubMed ID: 20434480	2010
Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing research reviews\| PubMed ID: 20438881	2010
Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PloS one\| PubMed ID: 20485503	2010
The hydrogen sulfide signaling system: changes during aging and the benefits of caloric restriction. Age (Dordrecht, Netherlands)\| PubMed ID: 20502969	2010
Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile. The journal of nutrition, health & aging\| PubMed ID: 20617288	2010
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PloS one\| PubMed ID: 20628647	2010
Myogenic and proteolytic mRNA expression following blood flow restricted exercise. Acta physiologica (Oxford, England)\| PubMed ID: 20653608	2011
Dietary restriction: standing up for sirtuins. Science (New York, N.Y.)\| PubMed ID: 20798296	2010
New insights into the role of mitochondria in aging: mitochondrial dynamics and more. Journal of cell science\| PubMed ID: 20940129	2010
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell\| PubMed ID: 21094524	2010
Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 21636833	2012
Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial. Clinical interventions in aging\| PubMed ID: 21753869	2011
Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventi... The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 21788651	2011
Mitochondria and aging. Journal of aging research\| PubMed ID: 21808737	2011
Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology\| PubMed ID: 21854730	2011
Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review. Gerontology\| PubMed ID: 21952604	2012
Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions. Microcirculation (New York, N.Y. : 1994)\| PubMed ID: 21954960	2012
The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity. Journal of aging research\| PubMed ID: 22013527	2011
Age-related differences in lower extremity tissue compartments and associations with physical function in older adults. Experimental gerontology\| PubMed ID: 22015325	2012
Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy. Experimental gerontology\| PubMed ID: 22085543	2012
Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine\| PubMed ID: 22088584	2011
Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae. Sub-cellular biochemistry\| PubMed ID: 22094422	2012
Critical role of autophage in ischemia/reperfusion injury to aged livers. Autophagy\| PubMed ID: 22170150	2012
Chronic pain, perceived stress, and cellular aging: an exploratory study. Molecular pain\| PubMed ID: 22325162	2012
Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. PloS one\| PubMed ID: 22389725	2012
Impaired iron status in aging research. International journal of molecular sciences\| PubMed ID: 22408459	2012
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities. Circulation research\| PubMed ID: 22499902	2012
The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging cell\| PubMed ID: 22681576	2012
Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction. Osteoarthritis and cartilage\| PubMed ID: 22863613	2012
Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding. Age (Dordrecht, Netherlands)\| PubMed ID: 22945739	2013
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biological chemistry\| PubMed ID: 23154422	2013
The effect of fasting on indicators of muscle damage. Experimental gerontology\| PubMed ID: 23266375	2013
Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Autophagy\| PubMed ID: 23298947	2013
Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast. Experimental gerontology\| PubMed ID: 23337777	2013
Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults. Journal of applied physiology (Bethesda, Md. : 1985)\| PubMed ID: 23493365	2014
Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation. Evolution; international journal of organic evolution\| PubMed ID: 23617928	2013
Fasting or caloric restriction for healthy aging. Experimental gerontology\| PubMed ID: 23639403	2013
Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged ani... Experimental gerontology\| PubMed ID: 23747682	2013
Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 23748424	2013
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. The international journal of biochemistry & cell biology\| PubMed ID: 23845738	2013
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PloS one\| PubMed ID: 23935986	2013
Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. PloS one\| PubMed ID: 24058615	2013
Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Critical care medicine\| PubMed ID: 24126442	2014
Aged mice are unable to mount an effective myeloid response to sepsis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24337739	2014
Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. The journal of trauma and acute care surgery\| PubMed ID: 24368353	2014
A better understanding of why murine models of trauma do not recapitulate the human syndrome. Critical care medicine\| PubMed ID: 24413577	2014
Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility. Current translational geriatrics and experimental gerontology reports\| PubMed ID: 24466503	2013
Protective immunity and defects in the neonatal and elderly immune response to sepsis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 24591376	2014
A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. Biochimica et biophysica acta\| PubMed ID: 24631828	2014
Host responses to sepsis vary in different low-lethality murine models. PloS one\| PubMed ID: 24788351	2014
Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study. Experimental gerontology\| PubMed ID: 24866496	2014
Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity. Free radical biology & medicine\| PubMed ID: 24975655	2014
The authors reply. Critical care medicine\| PubMed ID: 25126819	2014
Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery. American journal of respiratory and critical care medicine\| PubMed ID: 25271750	2014
Brown adipose tissue and the cold war against obesity. Diabetes\| PubMed ID: 25414014	2014
Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. Rejuvenation research\| PubMed ID: 25546413	2015
Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach. Frontiers in medicine\| PubMed ID: 25593902	2014
Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise. Medicine and science in sports and exercise\| PubMed ID: 25606815	2015
Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock. Critical care (London, England)\| PubMed ID: 25880307	2015
Current nutritional recommendations and novel dietary strategies to manage sarcopenia. The Journal of frailty & aging\| PubMed ID: 26082911	2013
Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects. BMC immunology\| PubMed ID: 26204934	2015
A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 26246141	2015
Age-related cellular changes in the long-lived bivalve A. islandica. Age (Dordrecht, Netherlands)\| PubMed ID: 26318854	2015
Calorie restriction for optimal cardiovascular aging: the weight of evidence. Current cardiovascular risk reports\| PubMed ID: 26388964	2010
Successful aging: Advancing the science of physical independence in older adults. Ageing research reviews\| PubMed ID: 26462882	2015
Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. The Journal of physiology\| PubMed ID: 26503074	2016
Low- Versus High-Intensity Plyometric Exercise During Rehabilitation After Anterior Cruciate Ligament Reconstruction. The American journal of sports medicine\| PubMed ID: 26797700	2016
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\| PubMed ID: 26799652	2016
Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle. Oncotarget\| PubMed ID: 27447862	2016
Autophagy in the liver: cell's cannibalism and beyond. Archives of pharmacal research\| PubMed ID: 27515049	2016
Integrated control of brown adipose tissue. Heart and metabolism : management of the coronary patient\| PubMed ID: 27524955	2016
"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content. Experimental gerontology\| PubMed ID: 27620821	2016
Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. Experimental gerontology\| PubMed ID: 27647172	2016
Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. Journal of translational medicine\| PubMed ID: 27687713	2016
Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers. Journal of geriatric oncology\| PubMed ID: 27743848	2017
Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study. Journal of translational medicine\| PubMed ID: 27784315	2016
Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 27807171	2016
Systemic inflammation, body composition, and physical performance in old community-dwellers. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 27897412	2017
Erratum to: Walking performance is positively correlated to calf muscle fiber size in peripheral artery disease subjects, but fibers show aberrant mitophagy: an observational study. Journal of translational medicine\| PubMed ID: 28241774	2017
Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial. JAMA cardiology\| PubMed ID: 28403379	2017
Exercise-Induced Autophagy in Fatty Liver Disease. Exercise and sport sciences reviews\| PubMed ID: 28419000	2017
Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation. Shock (Augusta, Ga.)\| PubMed ID: 28452909	2017
Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets. International journal of molecular sciences\| PubMed ID: 28452964	2017
ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design. Journal of the American Geriatrics Society\| PubMed ID: 28734043	2017
Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials. Nutrients\| PubMed ID: 28758964	2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients. BMJ open\| PubMed ID: 28765125	2017
Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults. Journal of the American Geriatrics Society\| PubMed ID: 28799216	2017
Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial. Contemporary clinical trials communications\| PubMed ID: 28944303	2017
HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study. Shock (Augusta, Ga.)\| PubMed ID: 29049133	2018
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity (Silver Spring, Md.)\| PubMed ID: 29086496	2018
Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders. Rejuvenation research\| PubMed ID: 29125070	2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients. The journal of trauma and acute care surgery\| PubMed ID: 29251709	2018
Persistent injury-associated anemia in aged rats. Experimental gerontology\| PubMed ID: 29307734	2018
Persistent injury-associated anemia and aging: Novel insights. The journal of trauma and acute care surgery\| PubMed ID: 29466280	2018
Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance. Vascular medicine (London, England)\| PubMed ID: 29734865	2018
The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods. European journal of internal medicine\| PubMed ID: 29753582	2018
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. Aging cell\| PubMed ID: 29774638	2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery. Surgery\| PubMed ID: 29807651	2018
Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. Free radical biology & medicine\| PubMed ID: 29969715	2018
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. Nature reviews. Cardiology\| PubMed ID: 30042431	2018
HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock. PloS one\| PubMed ID: 30216360	2018
Persistent inflammation and anemia among critically ill septic patients. The journal of trauma and acute care surgery\| PubMed ID: 30489504	2019
Effect of Losartan and Fish Oil on Plasma IL-6 and Mobility in Older Persons. The ENRGISE Pilot Randomized Clinical Trial. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 30541065	2019
Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in th... Biomolecules\| PubMed ID: 30563025	2018
Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise. Expert opinion on therapeutic targets\| PubMed ID: 30580640	2019
Glycine supplementation extends lifespan of male and female mice. Aging cell\| PubMed ID: 30916479	2019
Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. International journal of molecular sciences\| PubMed ID: 31137890	2019
Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors. Critical care (London, England)\| PubMed ID: 31234943	2019
Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease. Journal of the American Heart Association\| PubMed ID: 31257970	2019
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study. Nutrients\| PubMed ID: 31262054	2019
Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model. Critical care medicine\| PubMed ID: 31389840	2019
LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock. BMJ open\| PubMed ID: 31537565	2019
Differential response to targeted acupuncture by gender in patients with gastrointestinal cancer cachexia: secondary analysis of a randomized controlled trial. Acupuncture in medicine : journal of the British Medical Acupuncture Society\| PubMed ID: 31544469	2020
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis. Critical care (London, England)\| PubMed ID: 31722736	2019
Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. Cells\| PubMed ID: 31783583	2019
Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease. Journal of vascular surgery\| PubMed ID: 31870756	2020
American Heart Association Vascular Disease Strategically Focused Research Network. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 31969016	2020
Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial. Circulation research\| PubMed ID: 32078436	2020
Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival. Journal of the American Geriatrics Society\| PubMed ID: 32294254	2020
Meaningful change in 6-minute walk in people with peripheral artery disease. Journal of vascular surgery\| PubMed ID: 32335305	2021
Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease. Journal of the American Heart Association\| PubMed ID: 32390569	2020
Clinical characteristics and response to supervised exercise therapy of people with lower extremity peripheral artery disease. Journal of vascular surgery\| PubMed ID: 32416309	2021
Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults? Experimental gerontology\| PubMed ID: 32450270	2020
Associations of Poly (ADP-Ribose) Polymerase1 abundance in calf skeletal muscle with walking performance in peripheral artery disease. Experimental gerontology\| PubMed ID: 32755612	2020
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice. Shock (Augusta, Ga.)\| PubMed ID: 32826817	2021
Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease. Free radical biology & medicine\| PubMed ID: 32911084	2020
Skeletal Muscle Pathology in Peripheral Artery Disease: A Brief Review. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 32938218	2020
Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial. Experimental gerontology\| PubMed ID: 33068691	2021
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 33140449	2021
The Effect of Aging Physiology on Critical Care. Critical care clinics\| PubMed ID: 33190766	2021
Innovations in Geroscience to enhance mobility in older adults. Experimental gerontology\| PubMed ID: 33191210	2020
Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults. Cells\| PubMed ID: 33276460	2020
Vascular dysfunction as a potential culprit of sarcopenia. Experimental gerontology\| PubMed ID: 33373710	2021
Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial. Journal of the American College of Emergency Physicians open\| PubMed ID: 33392541	2020
A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response. GeroScience\| PubMed ID: 33527323	2021
The Age-Sensitive Efficacy of Calorie Restriction on Mitochondrial Biogenesis and mtDNA Damage in Rat Liver. International journal of molecular sciences\| PubMed ID: 33562258	2021
Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 33721883	2022
Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial. JAMA\| PubMed ID: 33821898	2021
Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in... Vascular medicine (London, England)\| PubMed ID: 33829920	2021
Assessing the feasibility of using the short physical performance battery to measure function in the immediate postoperative period after total knee replacement. European journal of translational myology\| PubMed ID: 33840178	2021
Lipid and Lipoprotein Dysregulation in Sepsis: Clinical and Mechanistic Insights into Chronic Critical Illness. Journal of clinical medicine\| PubMed ID: 33920038	2021
Lipid and lipoprotein predictors of functional outcomes and long-term mortality after surgical sepsis. Annals of intensive care\| PubMed ID: 34018068	2021
Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease. Circulation research\| PubMed ID: 34110902	2021
The COVID-19 pandemic and physical activity. Sports medicine and health science\| PubMed ID: 34189484	2020
The impact of sarcopenia and acute muscle mass loss on long-term outcomes in critically ill patients with intra-abdominal sepsis. Journal of cachexia, sarcopenia and muscle\| PubMed ID: 34196134	2021
Chronic Critical Illness Elicits a Unique Circulating Leukocyte Transcriptome in Sepsis Survivors. Journal of clinical medicine\| PubMed ID: 34361995	2021
Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers. Cells\| PubMed ID: 34440632	2021
Blood flow restriction exercise to attenuate postoperative loss of function after total knee replacement: a randomized pilot study. European journal of translational myology\| PubMed ID: 34459574	2021
Comparative toxicities of BPA, BPS, BPF, and TMBPF in the nematode Caenorhabditis elegans and mammalian fibroblast cells. Toxicology\| PubMed ID: 34474090	2021
A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes. Critical care (London, England)\| PubMed ID: 34535154	2021
Iron homeostasis and organismal aging. Ageing research reviews\| PubMed ID: 34767974	2021
Inflammation in Relation to Sarcopenia and Sarcopenic Obesity among Older Adults Living with Chronic Comorbidities: Results from the National Health and Nutrition Examination Survey 1999-200... Nutrients\| PubMed ID: 34836213	2021
Sex differences associate with late microbiome alterations after murine surgical sepsis. The journal of trauma and acute care surgery\| PubMed ID: 35324554	2022
Mitochondrial-derived vesicles in skeletal muscle remodeling and adaptation. Seminars in cell & developmental biology\| PubMed ID: 35367122	2023
Post-meeting report of the 2022 On-site Padua Days on Muscle and Mobility Medicine, March 30 - April 3, 2022, Padua, Italy. European journal of translational myology\| PubMed ID: 35421919	2022
Time-Restricted Eating Regimen Differentially Affects Circulatory miRNA Expression in Older Overweight Adults. Nutrients\| PubMed ID: 35565812	2022
Frailty and risk of mortality in older cancer survivors and adults without a cancer history: Evidence from the National Health and Nutrition Examination Survey, 1999-2014. Cancer\| PubMed ID: 35608563	2022
Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors. JAMA network open\| PubMed ID: 35731518	2022
Effects of Walking Exercise at a Pace With Versus Without Ischemic Leg Symptoms on Functional Performance Measures in People With Lower Extremity Peripheral Artery Disease: The LITE Randomiz... Journal of the American Heart Association\| PubMed ID: 35894088	2022
Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease: The TELEX Randomized Clinical Trial. JAMA\| PubMed ID: 36194220	2022
Dysregulated Genes, MicroRNAs, Biological Pathways, and Gastrocnemius Muscle Fiber Types Associated With Progression of Peripheral Artery Disease: A Preliminary Analysis. Journal of the American Heart Association\| PubMed ID: 36300658	2022
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study. GeroScience\| PubMed ID: 36367600	2022
Low muscle mass is associated with a higher risk of all-cause and cardiovascular disease-specific mortality in cancer survivors. Nutrition (Burbank, Los Angeles County, Calif.)\| PubMed ID: 36563433	2023
Cigarette smoking and mitochondrial dysfunction in peripheral artery disease. Vascular medicine (London, England)\| PubMed ID: 36567551	2023
Relationship between Mitochondrial Quality Control Markers, Lower Extremity Tissue Composition, and Physical Performance in Physically Inactive Older Adults. Cells\| PubMed ID: 36611976	2023
Autophagy Meets Aging: An Overview. Cells\| PubMed ID: 36766829	2023
Mitochondrial Complex Abundance, Mitophagy Proteins, and Physical Performance in People With and Without Peripheral Artery Disease. Journal of the American Heart Association\| PubMed ID: 36892048	2023
2023 Padua Days of Muscle and Mobility Medicine: post-meeting Book of Abstracts. European journal of translational myology\| PubMed ID: 37114363	2023
Transcriptomic and Proteomic of Gastrocnemius Muscle in Peripheral Artery Disease. Circulation research\| PubMed ID: 37154037	2023
Inflammatory, mitochondrial, and senescence-related markers: Underlying biological pathways of muscle aging and new therapeutic targets. Experimental gerontology\| PubMed ID: 37169101	2023
The contribution of mitochondrial DNA alterations to aging, cancer, and neurodegeneration. Experimental gerontology\| PubMed ID: 37172915	2023
Intraoperative Hemi-Diaphragm Electrical Stimulation Demonstrates Attenuated Mitochondrial Function without Change in Oxidative Stress in Cardiothoracic Surgery Patients. Antioxidants (Basel, Switzerland)\| PubMed ID: 37237876	2023
Allostatic load and risk of all-cause, cancer-specific, and cardiovascular mortality in older cancer survivors: an analysis of the National Health and Nutrition Examination Survey 1999-2010. Aging and cancer\| PubMed ID: 37576467	2023
Frontal adenosine triphosphate markers from P MRS are associated with cognitive performance in healthy older adults: preliminary findings. Frontiers in aging neuroscience\| PubMed ID: 37614473	2023
Hospitalizations during home-based walking exercise interventions in peripheral artery disease: Results from two randomized clinical trials. Vascular medicine (London, England)\| PubMed ID: 37622748	2023
Study Design, Rationale, and Methodology for Promote Weight Loss in Patients With Peripheral Artery Disease Who Also Have Obesity: The PROVE Trial. Journal of the American Heart Association\| PubMed ID: 37642035	2023
Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and are Reduced by Physical Activity in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 37948612	2023
Five Padua days on muscle and mobility medicine (2024Pdm3) 27 February - 2 March, 2024 at Hotel Petrarca, Thermae of Euganean Hills, Padua, and San Luca Hall, Prato della Valle, Padua, Italy... European journal of translational myology\| PubMed ID: 38112609	2023