ovarian-tissue-oocyte-in-vitro-maturation-for-fertility-preservation

Ovarian Tissue Oocyte-<em>In Vitro</em> Maturation for Fertility Preservation

Mature oocyte vitrification is the standard of care to preserve fertility in women at risk of infertility. However, ovarian tissue cryopreservation (OTC) ...

Vrije Universiteit Brussel

To investigate whether treatment with commercially available ready-to-use A23187 ionophore (GM508-CultActive) improves embryo development outcome in patients with a history of embryo developmental problems.

Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study.

What have we learnt after 10 years of electronic witnessing?

Electronic witnessing in the medically assisted reproduction laboratory: insights and considerations after 10 years of use.

Active systems - including sperm cells, living organisms like bacteria, fish, birds, or active soft matter systems like synthetic "microswimmers" - are characterized by motility, , the ability to propel using their own "engine". Motility is the key feature that distinguishes active systems from passive or externally driven systems. In a large ensemble, motility of individual species can vary in a wide range. Selecting active species according to their motility represents an exciting and challenging problem. We propose a new method for selecting active species based on their motility using an acoustofluidic setup where highly motile species escape from the acoustic trap. This is demonstrated in simulations and in experiments with self-propelled Janus particles and human sperm. The immediate application of this method is selecting highly motile sperm for medically assisted reproduction (MAR). Due to the tunable acoustic trap, the proposed method is more flexible than the existing passive microfluidic methods. The proposed selection method based on motility can also be applied to other active systems that require selecting highly motile species or removing immotile species.

Article	Year
Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study. Journal of assisted reproduction and genetics\| PubMed ID: 35357606	2022
Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study. Journal of assisted reproduction and genetics\| PubMed ID: 35543805	2022
Electronic witnessing in the medically assisted reproduction laboratory: insights and considerations after 10 years of use. Human reproduction (Oxford, England)\| PubMed ID: 37295967	2023
Selecting active matter according to motility in an acoustofluidic setup: self-propelled particles and sperm cells. Soft matter\| PubMed ID: 37917007	2023

Koen Wouters

Biography

JoVE Journal Publications

Other Publications