Ken E. Olson

Center for Vector-borne Infectious Diseases, Colorado State University

Affiliated withColorado State University

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 3	2023

Other Publications

Article	Year
Inhibition of luciferase expression in transgenic Aedes aegypti mosquitoes by Sindbis virus expression of antisense luciferase RNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10557332
Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes. Clinical microbiology reviews\| PubMed ID: 11023962
Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication. Journal of virology\| PubMed ID: 11222725
Developing arbovirus resistance in mosquitoes. Insect biochemistry and molecular biology\| PubMed ID: 12225924	2002
Flavivirus susceptibility in Aedes aegypti. Archives of medical research\| PubMed ID: 12234528	2002
Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States. The American journal of tropical medicine and hygiene\| PubMed ID: 12363070	2002
Genetic variation within the premembrane coding region of dengue viruses from the Yucatan peninsula of Mexico. The American journal of tropical medicine and hygiene\| PubMed ID: 12363071	2002
RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome. Journal of virology\| PubMed ID: 12438618	2002
Deletions in the putative cell receptor-binding domain of Sindbis virus strain MRE16 E2 glycoprotein reduce midgut infectivity in Aedes aegypti. Journal of virology\| PubMed ID: 12885905	2003
Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14668449	2003
Comparison of the transmission potential of two genetically distinct Sindbis viruses after oral infection of Aedes aegypti (Diptera: Culicidae). Journal of medical entomology\| PubMed ID: 14989352	2004
RNA interference, arthropod-borne viruses, and mosquitoes. Virus research\| PubMed ID: 15068882	2004
Using RNA interference to develop dengue virus resistance in genetically modified Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 15242701	2004
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15583140	2004
Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537508	2006
Infectious clone construction of dengue virus type 2, strain Jamaican 1409, and characterization of a conditional E6 mutation. The Journal of general virology\| PubMed ID: 16847122	2006
Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes. BMC microbiology\| PubMed ID: 17263893	2007
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. Journal of virology\| PubMed ID: 17344298	2007
Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti. The Journal of general virology\| PubMed ID: 17412985	2007
Recombination-ready Sindbis replicon expression vectors for transgene expression. Virology journal\| PubMed ID: 17963504	2007
Genetic determinants of Sindbis virus mosquito infection are associated with a highly conserved alphavirus and flavivirus envelope sequence. Journal of virology\| PubMed ID: 18160430	2008
Annotation and expression profiling of apoptosis-related genes in the yellow fever mosquito, Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 18252247	2008
Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC microbiology\| PubMed ID: 18366655	2008
Alphavirus transducing systems. Advances in experimental medicine and biology\| PubMed ID: 18510011	2008
The effects of midgut serine proteases on dengue virus type 2 infectivity of Aedes aegypti. The American journal of tropical medicine and hygiene\| PubMed ID: 18689635	2008
Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells. The Journal of general virology\| PubMed ID: 18931060	2008
Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway. PLoS pathogens\| PubMed ID: 19214215	2009
Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes. BMC microbiology\| PubMed ID: 19265532	2009
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. The Journal of general virology\| PubMed ID: 19403754	2009
The neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for Dengue 2 virus. PLoS neglected tropical diseases\| PubMed ID: 19564909	2009
Stability and loss of a virus resistance phenotype over time in transgenic mosquitoes harbouring an antiviral effector gene. Insect molecular biology\| PubMed ID: 19754743
Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. Journal of insect physiology\| PubMed ID: 20100490	2010
The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti. BMC microbiology\| PubMed ID: 20426860	2010
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. Antiviral research\| PubMed ID: 20452378	2010
Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito, Aedes aegypti. Insect molecular biology\| PubMed ID: 20738425
Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells. PLoS neglected tropical diseases\| PubMed ID: 21049014	2010
C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS neglected tropical diseases\| PubMed ID: 21049065	2010
RNA-seq analyses of blood-induced changes in gene expression in the mosquito vector species, Aedes aegypti. BMC genomics\| PubMed ID: 21276245	2011
Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense. BMC microbiology\| PubMed ID: 21356105	2011
Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and ΦC31 site-directed recombination. Insect molecular biology\| PubMed ID: 21699593
Infectious alphavirus production from a simple plasmid transfection+. Virology journal\| PubMed ID: 21771308	2011
Strain Variation in the Transcriptome of the Dengue Fever Vector, Aedes aegypti. G3 (Bethesda, Md.)\| PubMed ID: 22384387	2012
Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti. PloS one\| PubMed ID: 23028502
Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection. PloS one\| PubMed ID: 23209765	2012
Modeling dynamic introduction of Chikungunya virus in the United States. PLoS neglected tropical diseases\| PubMed ID: 23209859
Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice. PloS one\| PubMed ID: 23301074
Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus. PloS one\| PubMed ID: 23544138
Isolation of midgut escape mutants of two American genotype dengue 2 viruses from Aedes aegypti. Virology journal\| PubMed ID: 23937713
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses. Journal of virology\| PubMed ID: 24257615
Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes. PloS one\| PubMed ID: 24367703	2013
Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain. PLoS neglected tropical diseases\| PubMed ID: 24810399	2014
A "microRNA-like" small RNA expressed by Dengue virus? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24853506
Mosquito immune responses to arbovirus infections. Current opinion in insect science\| PubMed ID: 25401084
The role of RNA interference (RNAi) in arbovirus-vector interactions. Viruses\| PubMed ID: 25690800
Arbovirus-mosquito interactions: RNAi pathway. Current opinion in virology\| PubMed ID: 26629932
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. Journal of virology\| PubMed ID: 27053560
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. Virology\| PubMed ID: 27632563
Nonretroviral integrated RNA viruses in arthropod vectors: an occasional event or something more? Current opinion in insect science\| PubMed ID: 28805638
Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model. Virology\| PubMed ID: 29310105
Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters. Viruses\| PubMed ID: 29724035
Demonstration of efficient vertical and venereal transmission of dengue virus type-2 in a genetically diverse laboratory strain of Aedes aegypti. PLoS neglected tropical diseases\| PubMed ID: 30169505
Analysis of Salivary Glands and Saliva from and Infected with Chikungunya Viruses. Insects\| PubMed ID: 30717086
Induction of RNA interference to block Zika virus replication and transmission in the mosquito Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 31103782	2019
The Widespread Occurrence and Potential Biological Roles of Endogenous Viral Elements in Insect Genomes. Current issues in molecular biology\| PubMed ID: 31167954
Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. NPJ Parkinson's disease\| PubMed ID: 31531390
Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements. eLife\| PubMed ID: 31621580
Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by . Insects\| PubMed ID: 31940960
The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic . Viruses\| PubMed ID: 33142991	2020
The Genetic Basis for Salivary Gland Barriers to Arboviral Transmission. Insects\| PubMed ID: 33467430	2021
Current Effector and Gene-Drive Developments to Engineer Arbovirus-Resistant Aedes aegypti (Diptera: Culicidae) for a Sustainable Population Replacement Strategy in the Field. Journal of medical entomology\| PubMed ID: 33704462	2021
Nootkatone Is an Effective Repellent against and . Insects\| PubMed ID: 33925333	2021
Intrathoracic Inoculation of Zika Virus in . Bio-protocol\| PubMed ID: 34692914	2021
Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization. International journal of molecular sciences\| PubMed ID: 34884537	2021
Assessing single-locus CRISPR/Cas9-based gene drive variants in the mosquito Aedes aegypti via single-generation crosses and modeling. G3 (Bethesda, Md.)\| PubMed ID: 36250791	2022
Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti. Scientific reports\| PubMed ID: 37045866	2023

Article	Year
Inhibition of luciferase expression in transgenic Aedes aegypti mosquitoes by Sindbis virus expression of antisense luciferase RNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10557332
Molecular strategies for interrupting arthropod-borne virus transmission by mosquitoes. Clinical microbiology reviews\| PubMed ID: 11023962
Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication. Journal of virology\| PubMed ID: 11222725
Developing arbovirus resistance in mosquitoes. Insect biochemistry and molecular biology\| PubMed ID: 12225924	2002
Flavivirus susceptibility in Aedes aegypti. Archives of medical research\| PubMed ID: 12234528	2002
Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States. The American journal of tropical medicine and hygiene\| PubMed ID: 12363070	2002
Genetic variation within the premembrane coding region of dengue viruses from the Yucatan peninsula of Mexico. The American journal of tropical medicine and hygiene\| PubMed ID: 12363071	2002
RNA silencing of dengue virus type 2 replication in transformed C6/36 mosquito cells transcribing an inverted-repeat RNA derived from the virus genome. Journal of virology\| PubMed ID: 12438618	2002
Deletions in the putative cell receptor-binding domain of Sindbis virus strain MRE16 E2 glycoprotein reduce midgut infectivity in Aedes aegypti. Journal of virology\| PubMed ID: 12885905	2003
Use of Sindbis virus-mediated RNA interference to demonstrate a conserved role of Broad-Complex in insect metamorphosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14668449	2003
Comparison of the transmission potential of two genetically distinct Sindbis viruses after oral infection of Aedes aegypti (Diptera: Culicidae). Journal of medical entomology\| PubMed ID: 14989352	2004
RNA interference, arthropod-borne viruses, and mosquitoes. Virus research\| PubMed ID: 15068882	2004
Using RNA interference to develop dengue virus resistance in genetically modified Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 15242701	2004
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15583140	2004
Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegypti. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537508	2006
Infectious clone construction of dengue virus type 2, strain Jamaican 1409, and characterization of a conditional E6 mutation. The Journal of general virology\| PubMed ID: 16847122	2006
Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes. BMC microbiology\| PubMed ID: 17263893	2007
La Crosse bunyavirus nonstructural protein NSs serves to suppress the type I interferon system of mammalian hosts. Journal of virology\| PubMed ID: 17344298	2007
Genetic determinants of Sindbis virus strain TR339 affecting midgut infection in the mosquito Aedes aegypti. The Journal of general virology\| PubMed ID: 17412985	2007
Recombination-ready Sindbis replicon expression vectors for transgene expression. Virology journal\| PubMed ID: 17963504	2007
Genetic determinants of Sindbis virus mosquito infection are associated with a highly conserved alphavirus and flavivirus envelope sequence. Journal of virology\| PubMed ID: 18160430	2008
Annotation and expression profiling of apoptosis-related genes in the yellow fever mosquito, Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 18252247	2008
Aedes aegypti uses RNA interference in defense against Sindbis virus infection. BMC microbiology\| PubMed ID: 18366655	2008
Alphavirus transducing systems. Advances in experimental medicine and biology\| PubMed ID: 18510011	2008
The effects of midgut serine proteases on dengue virus type 2 infectivity of Aedes aegypti. The American journal of tropical medicine and hygiene\| PubMed ID: 18689635	2008
Effects of inducing or inhibiting apoptosis on Sindbis virus replication in mosquito cells. The Journal of general virology\| PubMed ID: 18931060	2008
Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway. PLoS pathogens\| PubMed ID: 19214215	2009
Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes. BMC microbiology\| PubMed ID: 19265532	2009
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. The Journal of general virology\| PubMed ID: 19403754	2009
The neovolcanic axis is a barrier to gene flow among Aedes aegypti populations in Mexico that differ in vector competence for Dengue 2 virus. PLoS neglected tropical diseases\| PubMed ID: 19564909	2009
Stability and loss of a virus resistance phenotype over time in transgenic mosquitoes harbouring an antiviral effector gene. Insect molecular biology\| PubMed ID: 19754743
Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. Journal of insect physiology\| PubMed ID: 20100490	2010
The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti. BMC microbiology\| PubMed ID: 20426860	2010
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. Antiviral research\| PubMed ID: 20452378	2010
Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito, Aedes aegypti. Insect molecular biology\| PubMed ID: 20738425
Comparison of dengue virus type 2-specific small RNAs from RNA interference-competent and -incompetent mosquito cells. PLoS neglected tropical diseases\| PubMed ID: 21049014	2010
C6/36 Aedes albopictus cells have a dysfunctional antiviral RNA interference response. PLoS neglected tropical diseases\| PubMed ID: 21049065	2010
RNA-seq analyses of blood-induced changes in gene expression in the mosquito vector species, Aedes aegypti. BMC genomics\| PubMed ID: 21276245	2011
Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense. BMC microbiology\| PubMed ID: 21356105	2011
Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and ΦC31 site-directed recombination. Insect molecular biology\| PubMed ID: 21699593
Infectious alphavirus production from a simple plasmid transfection+. Virology journal\| PubMed ID: 21771308	2011
Strain Variation in the Transcriptome of the Dengue Fever Vector, Aedes aegypti. G3 (Bethesda, Md.)\| PubMed ID: 22384387	2012
Rapid intraspecific evolution of miRNA and siRNA genes in the mosquito Aedes aegypti. PloS one\| PubMed ID: 23028502
Complex modulation of the Aedes aegypti transcriptome in response to dengue virus infection. PloS one\| PubMed ID: 23209765	2012
Modeling dynamic introduction of Chikungunya virus in the United States. PLoS neglected tropical diseases\| PubMed ID: 23209859
Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice. PloS one\| PubMed ID: 23301074
Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus. PloS one\| PubMed ID: 23544138
Isolation of midgut escape mutants of two American genotype dengue 2 viruses from Aedes aegypti. Virology journal\| PubMed ID: 23937713
Liposome-antigen-nucleic acid complexes protect mice from lethal challenge with western and eastern equine encephalitis viruses. Journal of virology\| PubMed ID: 24257615
Subgenomic reporter RNA system for detection of alphavirus infection in mosquitoes. PloS one\| PubMed ID: 24367703	2013
Fitness impact and stability of a transgene conferring resistance to dengue-2 virus following introgression into a genetically diverse Aedes aegypti strain. PLoS neglected tropical diseases\| PubMed ID: 24810399	2014
A "microRNA-like" small RNA expressed by Dengue virus? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24853506
Mosquito immune responses to arbovirus infections. Current opinion in insect science\| PubMed ID: 25401084
The role of RNA interference (RNAi) in arbovirus-vector interactions. Viruses\| PubMed ID: 25690800
Arbovirus-mosquito interactions: RNAi pathway. Current opinion in virology\| PubMed ID: 26629932
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. Journal of virology\| PubMed ID: 27053560
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. Virology\| PubMed ID: 27632563
Nonretroviral integrated RNA viruses in arthropod vectors: an occasional event or something more? Current opinion in insect science\| PubMed ID: 28805638
Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model. Virology\| PubMed ID: 29310105
Involvement of Pro-Inflammatory Macrophages in Liver Pathology of Pirital Virus-Infected Syrian Hamsters. Viruses\| PubMed ID: 29724035
Demonstration of efficient vertical and venereal transmission of dengue virus type-2 in a genetically diverse laboratory strain of Aedes aegypti. PLoS neglected tropical diseases\| PubMed ID: 30169505
Analysis of Salivary Glands and Saliva from and Infected with Chikungunya Viruses. Insects\| PubMed ID: 30717086
Induction of RNA interference to block Zika virus replication and transmission in the mosquito Aedes aegypti. Insect biochemistry and molecular biology\| PubMed ID: 31103782	2019
The Widespread Occurrence and Potential Biological Roles of Endogenous Viral Elements in Insect Genomes. Current issues in molecular biology\| PubMed ID: 31167954
Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. NPJ Parkinson's disease\| PubMed ID: 31531390
Control of RNA viruses in mosquito cells through the acquisition of vDNA and endogenous viral elements. eLife\| PubMed ID: 31621580
Antiviral Effectors and Gene Drive Strategies for Mosquito Population Suppression or Replacement to Mitigate Arbovirus Transmission by . Insects\| PubMed ID: 31940960
The Antiviral Small-Interfering RNA Pathway Induces Zika Virus Resistance in Transgenic . Viruses\| PubMed ID: 33142991	2020
The Genetic Basis for Salivary Gland Barriers to Arboviral Transmission. Insects\| PubMed ID: 33467430	2021
Current Effector and Gene-Drive Developments to Engineer Arbovirus-Resistant Aedes aegypti (Diptera: Culicidae) for a Sustainable Population Replacement Strategy in the Field. Journal of medical entomology\| PubMed ID: 33704462	2021
Nootkatone Is an Effective Repellent against and . Insects\| PubMed ID: 33925333	2021
Intrathoracic Inoculation of Zika Virus in . Bio-protocol\| PubMed ID: 34692914	2021
Piwi4 Structural Features Are Necessary for RNA Binding and Nuclear Localization. International journal of molecular sciences\| PubMed ID: 34884537	2021
Assessing single-locus CRISPR/Cas9-based gene drive variants in the mosquito Aedes aegypti via single-generation crosses and modeling. G3 (Bethesda, Md.)\| PubMed ID: 36250791	2022
Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti. Scientific reports\| PubMed ID: 37045866	2023