Radislav Sedlacek

Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences

Affiliated withInstitute of Molecular Genetics of the Czech Academy of Sciences

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 1	2023

Other Publications

Article	Year
Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity. BMC gastroenterology\| PubMed ID: 24172289	2013
Efficient gene targeting of the Rosa26 locus in mouse zygotes using TALE nucleases. FEBS letters\| PubMed ID: 25241166	2014
Transgenic reporter mice with promoter region of murine LRAT specifically marks lens and meiosis spermatocytes. Physiological research\| PubMed ID: 25317684	2015
KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-Like Phenotype. PLoS genetics\| PubMed ID: 28095415	2017
Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Human molecular genetics\| PubMed ID: 28173120	2016
Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28196895	2017
Plectin controls biliary tree architecture and stability in cholestasis. Journal of hepatology\| PubMed ID: 29273475	2018
The role of immune cell subpopulations in the growth and rejection of TC-1/A9 tumors in novel mouse strains differing in the H2-D haplotype and NKC domain. Oncology letters\| PubMed ID: 29467880	2018
Role of in maternal mRNA turnover. Life science alliance\| PubMed ID: 30456367	2018
Aire-expressing ILC3-like cells in the lymph node display potent APC features. The Journal of experimental medicine\| PubMed ID: 30918005	2019
c-Myb regulates tumorigenic potential of embryonal rhabdomyosarcoma cells. Scientific reports\| PubMed ID: 31004084	2019
Fam208a orchestrates interaction protein network essential for early embryonic development and cell division. Experimental cell research\| PubMed ID: 31112734	2019
Histone methyltransferase PRDM9 is not essential for meiosis in male mice. Genome research\| PubMed ID: 31186301	2019
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation. Genome biology\| PubMed ID: 31446895	2019
Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon. Cell death & disease\| PubMed ID: 31659152	2019
Toll-like receptor 2 expression on c-kit cells tracks the emergence of embryonic definitive hematopoietic progenitors. Nature communications\| PubMed ID: 31729371	2019
The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach. Journal of diabetes research\| PubMed ID: 31886287	2019
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. EMBO reports\| PubMed ID: 31919978	2020
High-throughput discovery of genetic determinants of circadian misalignment. PLoS genetics\| PubMed ID: 31929527	2020
Human and mouse essentiality screens as a resource for disease gene discovery. Nature communications\| PubMed ID: 32005800	2020
The Deep Genome Project. Genome biology\| PubMed ID: 32008577	2020
Dysregulated NADPH Oxidase Promotes Bone Damage in Murine Model of Autoinflammatory Osteomyelitis. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 32024700	2020
Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation. Nature communications\| PubMed ID: 32398640	2020
Efficient allele conversion in mouse zygotes and primary cells based on electroporation of Cre protein. Methods (San Diego, Calif.)\| PubMed ID: 32717290	2021
Cytotoxicity of the effector protein BteA was attenuated in Bordetella pertussis by insertion of an alanine residue. PLoS pathogens\| PubMed ID: 32776984	2020
The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner. International journal of molecular sciences\| PubMed ID: 32825187	2020
Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1. Cell reports\| PubMed ID: 33357424	2020
Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS genetics\| PubMed ID: 33370286	2020
Bardet-Biedl Syndrome ciliopathy is linked to altered hematopoiesis and dysregulated self-tolerance. EMBO reports\| PubMed ID: 33426789	2021
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB receptors. British journal of pharmacology\| PubMed ID: 33491188	2021
Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal immunology\| PubMed ID: 33674761	2021
Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. Nature\| PubMed ID: 33767445	2021
Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation". Genome biology\| PubMed ID: 33827648	2021
A resource of targeted mutant mouse lines for 5,061 genes. Nature genetics\| PubMed ID: 33833456	2021
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation. Cell reports\| PubMed ID: 33882302	2021
Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Gene. International journal of molecular sciences\| PubMed ID: 33916973	2021
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility. The EMBO journal\| PubMed ID: 33938018	2021
The iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release. Cellular and molecular life sciences : CMLS\| PubMed ID: 33950315	2021
Regulation of Inflammatory Response by Transmembrane Adaptor Protein LST1. Frontiers in immunology\| PubMed ID: 33986741	2021
CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation. International journal of molecular sciences\| PubMed ID: 34065512	2021
ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis. Scientific reports\| PubMed ID: 34075077	2021
Deletion of TLR2 erythro-myeloid progenitors leads to embryonic lethality in mice. European journal of immunology\| PubMed ID: 34107067	2021
Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate. Frontiers in cell and developmental biology\| PubMed ID: 34150743	2021
LAMP3 deficiency affects surfactant homeostasis in mice. PLoS genetics\| PubMed ID: 34161347	2021
Dual role of Fam208a during zygotic cleavage and early embryonic development. Experimental cell research\| PubMed ID: 34216590	2021
Retraction notice to "Fam208a orchestrates interaction protein network essential for early embryonic development and cell division" [Exp. Cell Res. 382 (1) (2019) 111437]. Experimental cell research\| PubMed ID: 34272044	2021
INFRAFRONTIER quality principles in systemic phenotyping. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 34328547	2022
Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice. Nature\| PubMed ID: 34345019	2021
Heterozygous Mutation Affects Glucose Tolerance in Male Rats. Genes\| PubMed ID: 34356103	2021
The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis. The Journal of biological chemistry\| PubMed ID: 34461100	2021
Correction: Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal immunology\| PubMed ID: 34686840	2022
Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies. Biological psychiatry\| PubMed ID: 34865853	2022
Multi-Level Approach for Comprehensive Enamel Phenotyping. Current protocols\| PubMed ID: 35007410	2022
Correction to: Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal immunology\| PubMed ID: 35301446	2022
Semantic clustering analysis of E3-ubiquitin ligases in gastrointestinal tract defines genes ontology clusters with tissue expression patterns. BMC gastroenterology\| PubMed ID: 35413796	2022
Genome-wide association study identifies kallikrein 5 in type 2 inflammation-low asthma. The Journal of allergy and clinical immunology\| PubMed ID: 35487308	2022
Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA . Non-coding RNA\| PubMed ID: 35645339	2022
Batch alignment via retention orders for preprocessing large-scale multi-batch LC-MS experiments. Bioinformatics (Oxford, England)\| PubMed ID: 35748696	2022
FBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation. Frontiers in cell and developmental biology\| PubMed ID: 35769260	2022
Full Assessment of Lung Mechanics Using Computer-Controlled, Forced Oscillation Technique. Current protocols\| PubMed ID: 35834677	2022
Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the Gene. Cells\| PubMed ID: 36139390	2022
Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections. Frontiers in immunology\| PubMed ID: 36275704	2022
LACTB induces cancer cell death through the activation of the intrinsic caspase-independent pathway in breast cancer. Apoptosis : an international journal on programmed cell death\| PubMed ID: 36282364	2023
Structural and functional basis of mammalian microRNA biogenesis by Dicer. Molecular cell\| PubMed ID: 36332606	2022
Analysis of genome-wide knockout mouse database identifies candidate ciliopathy genes. Scientific reports\| PubMed ID: 36456625	2022
Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2. bioRxiv : the preprint server for biology\| PubMed ID: 36482967	2022
Molecular interactions of adaptor protein PSTPIP2 control neutrophil-mediated responses leading to autoinflammation. Frontiers in immunology\| PubMed ID: 36605205	2022
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein. Science immunology\| PubMed ID: 36701425	2023
Genome-wide screening reveals the genetic basis of mammalian embryonic eye development. BMC biology\| PubMed ID: 36737727	2023
A structural model of the iRhom-ADAM17 sheddase complex reveals functional insights into its trafficking and activity. Cellular and molecular life sciences : CMLS\| PubMed ID: 37119365	2023
Variation in mouse chemical signals is genetically controlled and environmentally modulated. Scientific reports\| PubMed ID: 37237091	2023
Spatial Analysis of Nucleotide Metabolism: From CRISPR Knockout Cancer Cells to MALDI Imaging of Tumors. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 37258772	2023
Comprehensive ECG reference intervals in C57BL/6N substrains provide a generalizable guide for cardiac electrophysiology studies in mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 37294348	2023