establishment-pancreatic-cancer-derived-tumor-organoids-fibroblasts

Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Tumor organoids are three-dimensional (3D) ex vivo tumor models that recapitulate the biological key features of the original primary tumor tissues. ...

Hospital Universitario Ramón y Cajal

Chordoma is a rare malignant bone tumor. The outcome depends on the adequate surgical treatment with complete excision of the tumor with microscopic clear margins.

Sacral chordoma: management of a rare disease in a tertiary hospital.

Pancreatic cancer remains one of the most difficult cancers to treat with the poorest prognosis. The key to improving survival rates in this disease is early detection and monitoring of disseminated and residual disease. However, this is hindered due to lack reliable diagnostic and predictive markers which mean that the majority of patients succumb to their condition within a few months.

Circulating tumor cells (Ctc) and kras mutant circulating free Dna (cfdna) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer.

Leiomyomas are the most common benign tumors of the esophagus. Although classically surgical enucleation through thoracotomy or laparotomy has been widely accepted as treatment of choice, development of endoscopic and minimally invasive procedures has completely changed the surgical management of these tumors.

Comparative study between open and minimally invasive approach in the surgical management of esophageal leiomyoma.

Duodenal stump fistula (DSF) after gastrectomy has a low incidence but a high morbidity and mortality, and is therefore one of the most aggressive and feared complications of this procedure.

Duodenal fistula after gastrectomy: Retrospective study of 13 new cases.

a colonic stent as a bridge to elective surgery for left-sided malignant colonic obstruction is an alternative to the classical treatment. The aim of our study was to evaluate the recurrence rate as well as the morbidity and mortality of this treatment.

The long-term recurrence rate and survival of obstructive left-sided colon cancer patients: a stent as a bridge to surgery.

Currently, R1 resection is defined by the presence of tumor cells within <1mm of the resection margin. The main aim of this study was to analyze the impact of positive margins (R1) on survival outcomes in pancreatic cancer.

Relevance of positive resection margins in ductal pancreatic adenocarcinoma and prognostic factors.

Leiomyosarcoma of the right gonadal vein.

Postoperative pancreatic fistula in distal pancreatectomy is one of the most important complications in this surgery and it is associated with high morbidity and mortality. Pancreatic fistula after distal pancreatectomy remains an unsolved problem and none preventive procedure has been shown effectively. We present a new technique that combine pancreatic stent placement with round ligament autologous patch over pancreatic edge. A guide is introduced through Wirsung duct prior to stent placement. After stent assessment, Wirsung duct is closed. Finally, falciform ligament autologous patch is placed over pancreatic edge. After 6-8 weeks, the stent is removed by oral endoscopy. This technique introduces a new issue on the pancreatic fistula prevention.

Article	Year
Sacral chordoma: management of a rare disease in a tertiary hospital. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico\| PubMed ID: 22865326	2013
Circulating tumor cells (Ctc) and kras mutant circulating free Dna (cfdna) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancer. BMC cancer\| PubMed ID: 26498594	2015
Comparative study between open and minimally invasive approach in the surgical management of esophageal leiomyoma. Revista espanola de enfermedades digestivas\| PubMed ID: 26765229	2016
Duodenal fistula after gastrectomy: Retrospective study of 13 new cases. Revista espanola de enfermedades digestivas\| PubMed ID: 26765231	2016
The long-term recurrence rate and survival of obstructive left-sided colon cancer patients: a stent as a bridge to surgery. Revista espanola de enfermedades digestivas\| PubMed ID: 30071736	2018
Relevance of positive resection margins in ductal pancreatic adenocarcinoma and prognostic factors. Cirugia espanola\| PubMed ID: 31395275	2020
Leiomyosarcoma of the right gonadal vein. Cirugia espanola\| PubMed ID: 33143848	2020
Anterograde intraoperative pancreatic stent placement and round ligament patch to prevent pancreatic fistula after distal pancreatectomy. Cirugia espanola\| PubMed ID: 33388136	2021
Assesment, impact and management of moderate and severe duodenopancreatectomy complications. Cirugia espanola\| PubMed ID: 34082893	2021
Leiomyosarcoma of the right gonadal vein. Cirugia espanola\| PubMed ID: 34764061	2021
Assesment, impact and management of moderate and severe duodenopancreatectomy complications. Cirugia espanola\| PubMed ID: 35472531	2022

Eduardo Lobo

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