Stephen C. Pflugfelder

Cullen Eye Institute, Baylor College of Medicine

Affiliated withBaylor College of Medicine

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2023

Other Publications

Article	Year
Characterization of putative stem cell phenotype in human limbal epithelia. Stem cells (Dayton, Ohio)\| PubMed ID: 15153612	2004
Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Experimental eye research\| PubMed ID: 15183099	2004
Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Investigative ophthalmology & visual science\| PubMed ID: 15557435	2004
Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 15557436	2004
Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea\| PubMed ID: 15604871	2005
ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem cells (Dayton, Ohio)\| PubMed ID: 15625123	2005
Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. The American journal of pathology\| PubMed ID: 15632000	2005
Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 15728539	2005
Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Experimental eye research\| PubMed ID: 15781286	2005
Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab. Cornea\| PubMed ID: 16015096	2005
Effect of experimental dry eye on tear sodium concentration in the mouse. Eye & contact lens\| PubMed ID: 16021005	2005
Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16123387	2006
Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye & contact lens\| PubMed ID: 16163009	2005
JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Experimental eye research\| PubMed ID: 16202406	2006
Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem cells (Dayton, Ohio)\| PubMed ID: 16424398	2006
The incidence and risk factors for developing dry eye after myopic LASIK. American journal of ophthalmology\| PubMed ID: 16490488	2006
Expression and regulation of cornified envelope proteins in human corneal epithelium. Investigative ophthalmology & visual science\| PubMed ID: 16639001	2006
Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Experimental eye research\| PubMed ID: 16643899	2006
Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Experimental eye research\| PubMed ID: 16793039	2006
Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Investigative ophthalmology & visual science\| PubMed ID: 16799024	2006
Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Investigative ophthalmology & visual science\| PubMed ID: 16877394	2006
Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Molecular vision\| PubMed ID: 16943770	2006
Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 17003418	2006
Integrating restasis into the management of dry eye. International ophthalmology clinics\| PubMed ID: 17060796	2006
Anti-inflammatory therapy of dry eye. The ocular surface\| PubMed ID: 17075627	2003
The Ocular Surface Center at the Baylor College of Medicine, Houston. The ocular surface\| PubMed ID: 17075639	2003
Management of the late ocular sequelae of Stevens-Johnson syndrome. The ocular surface\| PubMed ID: 17075650	2003
Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye & contact lens\| PubMed ID: 17099387	2006
Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. The ocular surface\| PubMed ID: 17216108	2005
Matrix metalloproteinases in corneal inflammation. The ocular surface\| PubMed ID: 17216119	2005
Prominent corneal nerves in a patient with multiple myeloma. Cornea\| PubMed ID: 17251817	2007
Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea\| PubMed ID: 17457195	2007
Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Investigative ophthalmology & visual science\| PubMed ID: 17525184	2007
Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Investigative ophthalmology & visual science\| PubMed ID: 17525185	2007
Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea\| PubMed ID: 17525655	2007
Future directions in therapeutic interventions for conjunctival inflammatory disorders. Current opinion in allergy and clinical immunology\| PubMed ID: 17873588	2007
Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Experimental eye research\| PubMed ID: 17980361	2008
Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Molecular vision\| PubMed ID: 17982417	2007
Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. Journal of autoimmunity\| PubMed ID: 17988834	2008
Bilateral acanthamoeba keratitis. American journal of ophthalmology\| PubMed ID: 18222188	2008
Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Investigative ophthalmology & visual science\| PubMed ID: 18234997	2008
Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea\| PubMed ID: 18245969	2008
Prevalence, burden, and pharmacoeconomics of dry eye disease. The American journal of managed care\| PubMed ID: 18452369	2008
Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea\| PubMed ID: 18520508	2008
Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea\| PubMed ID: 18724157	2008
Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function. Eye & contact lens\| PubMed ID: 18779668	2008
Epithelial-immune cell interaction in dry eye. Cornea\| PubMed ID: 18813079	2008
Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Experimental eye research\| PubMed ID: 18938159	2008
Tear cytokine profiles in dysfunctional tear syndrome. American journal of ophthalmology\| PubMed ID: 18992869	2009
Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Investigative ophthalmology & visual science\| PubMed ID: 19151401	2009
Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Investigative ophthalmology & visual science\| PubMed ID: 19255163	2009
Corneal epithelial opacity in dysfunctional tear syndrome. American journal of ophthalmology\| PubMed ID: 19541283	2009
Induction of Th17 differentiation by corneal epithelial-derived cytokines. Journal of cellular physiology\| PubMed ID: 19746420	2010
Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Experimental eye research\| PubMed ID: 19799901	2010
Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Investigative ophthalmology & visual science\| PubMed ID: 19815739	2010
Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Investigative ophthalmology & visual science\| PubMed ID: 19850844	2010
Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. Journal of inflammation (London, England)\| PubMed ID: 19878594	2009
Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. The British journal of ophthalmology\| PubMed ID: 19965821	2010
Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford, England)\| PubMed ID: 20007286	2010
Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 20008718	2009
TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Investigative ophthalmology & visual science\| PubMed ID: 20107175	2010
Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Investigative ophthalmology & visual science\| PubMed ID: 20130281	2010
Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells. The international journal of biochemistry & cell biology\| PubMed ID: 20363357	2010
Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. Journal of cellular physiology\| PubMed ID: 20458737	2010
Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Investigative ophthalmology & visual science\| PubMed ID: 20505191	2010
Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Investigative ophthalmology & visual science\| PubMed ID: 20538995	2010
Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea\| PubMed ID: 20539212	2010
Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. The American journal of pathology\| PubMed ID: 20566743	2010
Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients. Investigative ophthalmology & visual science\| PubMed ID: 20631241	2011
Post-LASIK tear dysfunction and dysesthesia. The ocular surface\| PubMed ID: 20712970	2010
The successful use of Boston ocular surface prosthesis in the treatment of persistent corneal epithelial defect after herpes zoster ophthalmicus. Cornea\| PubMed ID: 20847682	2010
Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. American journal of ophthalmology\| PubMed ID: 20869039	2010
An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem cells (Dayton, Ohio)\| PubMed ID: 20936708	2010
The impact of the Boston ocular surface prosthesis on wavefront higher-order aberrations. American journal of ophthalmology\| PubMed ID: 21269603	2011
Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Investigative ophthalmology & visual science\| PubMed ID: 21273534	2011
The Î²-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells. The international journal of biochemistry & cell biology\| PubMed ID: 21292023	2011
Entrapment of conjunctival goblet cells by desiccation-induced cornification. Investigative ophthalmology & visual science\| PubMed ID: 21421863	2011
Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Investigative ophthalmology & visual science\| PubMed ID: 21474767	2011
TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. The international journal of biochemistry & cell biology\| PubMed ID: 21684348	2011
Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. The Journal of allergy and clinical immunology\| PubMed ID: 21820713	2011
Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ. The American journal of pathology\| PubMed ID: 21843497	2011
Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. American journal of ophthalmology\| PubMed ID: 22019306	2011
Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 22125404	2011
Disruption of TGF-β signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PloS one\| PubMed ID: 22194977	2011
Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells. Stem cells (Dayton, Ohio)\| PubMed ID: 22232078	2012
Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea\| PubMed ID: 22257864	2012
Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Investigative ophthalmology & visual science\| PubMed ID: 22395876	2012
Botulinum toxin injection for the management of refractory filamentary keratitis. Archives of ophthalmology (Chicago, Ill. : 1960)\| PubMed ID: 22491914	2012
NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PloS one\| PubMed ID: 22590618	2012
Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PloS one\| PubMed ID: 22723892	2012
Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. American journal of ophthalmology\| PubMed ID: 23036571	2013
Deletion of interferon-γ delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis research & therapy\| PubMed ID: 23116218	2012
Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea\| PubMed ID: 23146932	2013
A native-like corneal construct using donor corneal stroma for tissue engineering. PloS one\| PubMed ID: 23166715	2012
PROSE therapy used to minimize corneal trauma in patients with corneal epithelial defects. American journal of ophthalmology\| PubMed ID: 23218704	2013
Dry eye as a mucosal autoimmune disease. International reviews of immunology\| PubMed ID: 23360156	2013
Toll-like receptor expression and activation in mice with experimental dry eye. Investigative ophthalmology & visual science\| PubMed ID: 23372055	2013
Patient ocular conditions and clinical outcomes using a PROSE scleral device. Contact lens & anterior eye : the journal of the British Contact Lens Association\| PubMed ID: 23499361	2013
Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. Journal of clinical & experimental ophthalmology\| PubMed ID: 23560247	2011
Factors predicting the ocular surface response to desiccating environmental stress. Investigative ophthalmology & visual science\| PubMed ID: 23572103	2013
A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. PloS one\| PubMed ID: 23585867	2013
Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea\| PubMed ID: 23884332	2013
Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. Journal of leukocyte biology\| PubMed ID: 23983225	2013
T helper cytokines in dry eye disease. Experimental eye research\| PubMed ID: 24012834	2013
In vivo confocal microscopy of the ocular surface: from bench to bedside. Current eye research\| PubMed ID: 24215436	2014
Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PloS one\| PubMed ID: 24223818	2013
Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. American journal of ophthalmology\| PubMed ID: 24315297	2014
Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Experimental eye research\| PubMed ID: 24315969	2014
Atopic keratoconjunctivitis: A review. Journal of the American Academy of Dermatology\| PubMed ID: 24342754	2014
Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. The American journal of pathology\| PubMed ID: 24389165	2014
Effect of desiccating stress on mouse meibomian gland function. The ocular surface\| PubMed ID: 24439047	2014
A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Experimental eye research\| PubMed ID: 24486456	2014
What causes dryness in Sjögren's syndrome patients and how can it be targeted? Expert review of clinical immunology\| PubMed ID: 24564508	2014
New testing options for diagnosing and grading dry eye disease. American journal of ophthalmology\| PubMed ID: 24631478	2014
Human corneal epithelial cells produce antimicrobial peptides LL-37 and β-defensins in response to heat-killed Candida albicans. Ophthalmic research\| PubMed ID: 24662332	2014
Complications related to a cosmetic eye-whitening procedure. American journal of ophthalmology\| PubMed ID: 25072832	2014
Mucosal environmental sensors in the pathogenesis of dry eye. Expert review of clinical immunology\| PubMed ID: 25075545	2014
Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%. Eye & contact lens\| PubMed ID: 25083776	2014
Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Current eye research\| PubMed ID: 25271595	2015
Treatment of blepharitis: recent clinical trials. The ocular surface\| PubMed ID: 25284773	2014
Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25288568	2014
Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Molecular vision\| PubMed ID: 25352733	2014
Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS nano\| PubMed ID: 25585134	2015
Unique expression pattern and functional role of periostin in human limbal stem cells. PloS one\| PubMed ID: 25658308	2015
Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction. Investigative ophthalmology & visual science\| PubMed ID: 25758816	2015
Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Archivum immunologiae et therapiae experimentalis\| PubMed ID: 25772203	2015
Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. American journal of ophthalmology\| PubMed ID: 25868759	2015
Clinical guidelines for management of dry eye associated with Sjögren disease. The ocular surface\| PubMed ID: 25881996	2015
Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis research & therapy\| PubMed ID: 25889094	2015
Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PloS one\| PubMed ID: 26024535	2015
A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PloS one\| PubMed ID: 26039076	2015
IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Investigative ophthalmology & visual science\| PubMed ID: 26132778	2015
Dexamethasone nanowafer as an effective therapy for dry eye disease. Journal of controlled release : official journal of the Controlled Release Society\| PubMed ID: 26184051	2015
Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA ophthalmology\| PubMed ID: 26204109	2015
Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Investigative ophthalmology & visual science\| PubMed ID: 26225631	2015
Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. American journal of ophthalmology\| PubMed ID: 26255576	2015
Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells. Investigative ophthalmology & visual science\| PubMed ID: 26284556	2015
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Investigative ophthalmology & visual science\| PubMed ID: 26348638	2015
Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PloS one\| PubMed ID: 26402857	2015
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease. The ocular surface\| PubMed ID: 26549248	2016
Aqueous Tear Deficiency Increases Conjunctival Interferon-γ (IFN-γ) Expression and Goblet Cell Loss. Investigative ophthalmology & visual science\| PubMed ID: 26618646	2015
Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Scientific reports\| PubMed ID: 26762881	2016
Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. The ocular surface\| PubMed ID: 26772899	2016
Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. The ocular surface\| PubMed ID: 26807723	2016
Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. The ocular surface\| PubMed ID: 26882981	2016
MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. Journal of cellular physiology\| PubMed ID: 26923552	2016
Interferon-γ-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome. The American journal of pathology\| PubMed ID: 27085137	2016
Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. Scientific reports\| PubMed ID: 27087247	2016
Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Investigative ophthalmology & visual science\| PubMed ID: 27136463	2016
Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Investigative ophthalmology & visual science\| PubMed ID: 27327581	2016
Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Molecular pharmaceutics\| PubMed ID: 27571217	2016
Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget\| PubMed ID: 27623073	2016
Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal immunology\| PubMed ID: 27706128	2017
Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Scientific reports\| PubMed ID: 27796360	2016
LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 27906544	2017
Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. Journal of autoimmunity\| PubMed ID: 28238526	2017
Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. International journal of molecular sciences\| PubMed ID: 28273882	2017
Tear Volume-based Diagnostic Classification for Tear Dysfunction. International ophthalmology clinics\| PubMed ID: 28282310	2017
What We Have Learned From Animal Models of Dry Eye. International ophthalmology clinics\| PubMed ID: 28282318	2017
Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study. PloS one\| PubMed ID: 28301497	2017
Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. American journal of ophthalmology\| PubMed ID: 28302532	2017
Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital. The British journal of ophthalmology\| PubMed ID: 28336675	2017
Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. International journal of molecular sciences\| PubMed ID: 28475124	2017
Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Scientific reports\| PubMed ID: 28701781	2017
The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology\| PubMed ID: 29055361	2017
Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Experimental eye research\| PubMed ID: 29407221	2018
Goblet cell loss abrogates ocular surface immune tolerance. JCI insight\| PubMed ID: 29415888	2018
Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) scleral lens on visual acuity for corneal irregularity and ocular surface disease. The ocular surface\| PubMed ID: 29425812	2018
Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. International journal of molecular sciences\| PubMed ID: 29438346	2018
Near-infrared laser thermal conjunctivoplasty. Scientific reports\| PubMed ID: 29497112	2018
Protective role of commensal bacteria in Sjögren Syndrome. Journal of autoimmunity\| PubMed ID: 29934134	2018
Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 29958030	2018
Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. International immunology\| PubMed ID: 30010888	2018
Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. International journal of molecular sciences\| PubMed ID: 30223431	2018
Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie\| PubMed ID: 30502998	2018
Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome. International journal of molecular sciences\| PubMed ID: 30513621	2018
IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy\| PubMed ID: 30515838	2019
Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal immunology\| PubMed ID: 30696983	2019
Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal immunology\| PubMed ID: 31350466	2019
Topical cyclosporine A therapy for dry eye syndrome. The Cochrane database of systematic reviews\| PubMed ID: 31517988	2019
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. Ophthalmology\| PubMed ID: 31585826	2020
Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Investigative ophthalmology & visual science\| PubMed ID: 31618426	2019
The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome. The ocular surface\| PubMed ID: 31644955	2020
Ocular complications of atopic dermatitis. Cutis\| PubMed ID: 31675394	2019
Immune - Goblet cell interaction in the conjunctiva. The ocular surface\| PubMed ID: 31953222	2020
Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions. International journal of molecular sciences\| PubMed ID: 31963817	2020
Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Scientific reports\| PubMed ID: 32076085	2020
IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal immunology\| PubMed ID: 32358573	2020
Biological functions of tear film. Experimental eye research\| PubMed ID: 32561483	2020
Goblet cells promote tolerance induction in the conjunctiva. Mucosal immunology\| PubMed ID: 32616838	2020
Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics\| PubMed ID: 32721249	2020
Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress. Investigative ophthalmology & visual science\| PubMed ID: 32785678	2020
The cornea in keratoconjunctivitis sicca. Experimental eye research\| PubMed ID: 33038387	2020
Inflammatory basis for dry eye disease flares. Experimental eye research\| PubMed ID: 33039458	2020
Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment. American journal of ophthalmology case reports\| PubMed ID: 33094195	2020
Rapamycin Eyedrops Increased CD4Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. International journal of molecular sciences\| PubMed ID: 33255287	2020
Autophagy Activation Protects Ocular Surface from Inflammation in a Dry Eye Model In Vitro. International journal of molecular sciences\| PubMed ID: 33255884	2020
Defining Dry Eye from a Clinical Perspective. International journal of molecular sciences\| PubMed ID: 33291796	2020
Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human cornea. The ocular surface\| PubMed ID: 33388438	2021
Retinoid Regulation of Ocular Surface Innate Inflammation. International journal of molecular sciences\| PubMed ID: 33499199	2021
Conjunctivochalasis and Tear Osmolarity Are Associated With Reduced Conjunctival Epithelial Thickness in Dry Eye. American journal of ophthalmology\| PubMed ID: 33571473	2021
Video Viewing Blink Rate in Normal and Dry Eyes. Eye & contact lens\| PubMed ID: 33900215	2021
Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus. Investigative ophthalmology & visual science\| PubMed ID: 34297801	2021
Dry eye disease flares: A rapid evidence assessment. The ocular surface\| PubMed ID: 34303844	2021
Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis. Frontiers in immunology\| PubMed ID: 34305940	2021
Differentially Expressed Gene Pathways in the Conjunctiva of Sjögren Syndrome Keratoconjunctivitis Sicca. Frontiers in immunology\| PubMed ID: 34349764	2021
IL-36α/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress. The ocular surface\| PubMed ID: 34428579	2021
Combined therapy of ocular surface disease with plasma rich in growth factors and scleral contact lenses. The ocular surface\| PubMed ID: 34537416	2022
Gut-derived butyrate suppresses ocular surface inflammation. Scientific reports\| PubMed ID: 35296712	2022
Gut Microbiota From Sjögren syndrome Patients Causes Decreased T Regulatory Cells in the Lymphoid Organs and Desiccation-Induced Corneal Barrier Disruption in Mice. Frontiers in medicine\| PubMed ID: 35355610	2022
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes. Mucosal immunology\| PubMed ID: 35361907	2022
IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse. Frontiers in medicine\| PubMed ID: 35402439	2022
Author Correction: Gut-derived butyrate suppresses ocular surface inflammation. Scientific reports\| PubMed ID: 35449441	2022
A multicenter report of the use of plasma rich in growth factors (PRGF) for the treatment of patients with ocular surface diseases in North America. The ocular surface\| PubMed ID: 35489588	2022
Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease. The ocular surface\| PubMed ID: 35550851	2022
Imbalanced IL-37/TNF-α/CTSS signaling disrupts corneal epithelial barrier in a dry eye model in vitro. The ocular surface\| PubMed ID: 36208723	2022
Quantitative assessment of botulinum toxin injection on blink rate in blepharospasm. Orbit (Amsterdam, Netherlands)\| PubMed ID: 36484152	2022
Delphi Panel Consensus Regarding Current Clinical Practice Management Options for . Clinical ophthalmology (Auckland, N.Z.)\| PubMed ID: 36875531	2023
Non-invasive and objective tear film breakup detection on interference color images using convolutional neural networks. PloS one\| PubMed ID: 36913382	2023
Clinical diagnosis and management of Demodex blepharitis: the Demodex Expert Panel on Treatment and Eyelid Health (DEPTH). Eye (London, England)\| PubMed ID: 36964261	2023
Comparison of Efficacy and Inflammatory Response to Thermoconjunctivoplasty Performed with Cautery or Pulsed 1460 nm Laser. International journal of molecular sciences\| PubMed ID: 36982810	2023
Dry eye disease and blinking behaviors: A narrative review of methodologies for measuring blink dynamics and inducing blink response. The ocular surface\| PubMed ID: 37257694	2023
Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca. Translational vision science & technology\| PubMed ID: 37310735	2023