measuring-retinal-vessel-diameter-from-mouse-fluorescent-angiography

Measuring Retinal Vessel Diameter from Mouse Fluorescent Angiography Images

It is important to study the development of retinal vasculature in retinopathies in which abnormal vessel growth can ultimately lead to vision loss. ...

University of Iceland

Neuroplasticity forms the basis for neuronal circuit complexity and differences between otherwise similar circuits. We show that the microphthalmia-associated transcription factor () plays a central role in intrinsic plasticity of olfactory bulb (OB) projection neurons. Mitral and tufted (M/T) neurons from  mutant mice are hyperexcitable, have a reduced A-type potassium current (I) and exhibit reduced expression of , which encodes a potassium voltage-gated channel subunit (Kv4.3) important for generating the I Furthermore, expression of the  and  genes is activity dependent in OB projection neurons and the MITF protein activates expression from  regulatory elements. Moreover,  mutant mice have changes in olfactory habituation and have increased habituation for an odorant following long-term exposure, indicating that regulation of  is pivotal for long-term olfactory adaptation. Our findings show that  acts as a direct regulator of intrinsic homeostatic feedback and links neuronal activity, transcriptional changes and neuronal function.

Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity.

Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium. The purpose of this study was to assess the vascular changes in Mitf mice carrying pathogenic variants by determining their retinal vessel diameter.

Article	Year
Mitf Links Neuronal Activity and Long-Term Homeostatic Intrinsic Plasticity. eNeuro\| PubMed ID: 32193365	2020
Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature. Acta ophthalmologica\| PubMed ID: 35348289	2022

Hallur Reynisson

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