affinity-purification-of-a-fibrinolytic-enzyme-from-sipunculus-nudus

Affinity Purification of a Fibrinolytic Enzyme from <em>Sipunculus nudus</em>

The fibrinolytic enzyme from Sipunculus nudus (sFE) is a novel fibrinolytic agent that can both activate plasminogen into plasmin and degrade fibrin ...

rapid-separation-display-active-fibrinogenolytic-agents-sipunculus

Rapid Separation and Display of Active Fibrinogenolytic Agents in <i>Sipunculus nudus</i> through Fibrinogen-Polyacrylamide Gel Electrophoresis

Fibrinogenolytic agents that can dissolve fibrinogen directly have been widely used in anti-coagulation treatment. Generally, identifying new ...

Huaqiao University

huaqiao university

Thrombosis has been emerging as a major global life-threatening issue with high mortality and serious complications, especially in the post-COVID-19 era. Compared with the commonly used plasminogen activators thrombolytic drugs, fibrinolytic drugs are no longer heavily dependent on the patients' own plasminogen, which are poorly expressed in most patients. As a novel "direct acting" thrombolytic agent, fibrinolytic drugs are considered to have stronger thrombolytic efficacy and safety than the widely used plasminogen activators. However, the risk of their hemorrhage remains a major concern. Herein, the molecular mechanisms and solutions were summarized for the first time based on the systematic review of the latest developments, which could shed new light on the development of novel safety fibrinolytic drugs in the future.

ArticleTotal : 2	Year
Publication title Cited by 2	2023
Publication title Cited by 2	2024

Chengjia Hu

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JoVE Journal Publications

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